NO125850B - - Google Patents
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- Publication number
- NO125850B NO125850B NO2368/70A NO236870A NO125850B NO 125850 B NO125850 B NO 125850B NO 2368/70 A NO2368/70 A NO 2368/70A NO 236870 A NO236870 A NO 236870A NO 125850 B NO125850 B NO 125850B
- Authority
- NO
- Norway
- Prior art keywords
- mixture
- solvent
- lower alkyl
- hours
- temperature
- Prior art date
Links
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 235000019270 ammonium chloride Nutrition 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- -1 alkali metal cyanide Chemical class 0.000 claims description 3
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 2
- 206010018691 Granuloma Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- QGJOPFRUJISHPQ-NJFSPNSNSA-N carbon disulfide-14c Chemical compound S=[14C]=S QGJOPFRUJISHPQ-NJFSPNSNSA-N 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- OJEDWBCGPOCKJW-UHFFFAOYSA-N 1-cyclopentylpiperidin-4-one Chemical compound C1CC(=O)CCN1C1CCCC1 OJEDWBCGPOCKJW-UHFFFAOYSA-N 0.000 description 1
- HUUPVABNAQUEJW-UHFFFAOYSA-N 1-methylpiperidin-4-one Chemical compound CN1CCC(=O)CC1 HUUPVABNAQUEJW-UHFFFAOYSA-N 0.000 description 1
- CCDBCHAQIXKJCG-UHFFFAOYSA-N 1-propan-2-ylpiperidin-4-one Chemical compound CC(C)N1CCC(=O)CC1 CCDBCHAQIXKJCG-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1980169 | 1969-07-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO125850B true NO125850B (fr) | 1972-11-13 |
Family
ID=11161321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2368/70A NO125850B (fr) | 1969-07-18 | 1970-06-18 |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS4932541B1 (fr) |
| AT (1) | AT297729B (fr) |
| BE (1) | BE751650A (fr) |
| BR (1) | BR6914929D0 (fr) |
| CH (1) | CH511244A (fr) |
| DE (1) | DE2031359C3 (fr) |
| ES (1) | ES380780A1 (fr) |
| FI (1) | FI50244C (fr) |
| FR (1) | FR2059529B1 (fr) |
| GB (1) | GB1265134A (fr) |
| IL (1) | IL34702A (fr) |
| NL (1) | NL142682B (fr) |
| NO (1) | NO125850B (fr) |
| SE (1) | SE358394B (fr) |
| ZA (1) | ZA703809B (fr) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3542729A (en) * | 1968-03-19 | 1970-11-24 | Sankyo Co | Stabilization of synthetic polymers |
-
1969
- 1969-12-10 BR BR214929/69A patent/BR6914929D0/pt unknown
-
1970
- 1970-06-03 GB GB1265134D patent/GB1265134A/en not_active Expired
- 1970-06-04 ZA ZA703809A patent/ZA703809B/xx unknown
- 1970-06-08 BE BE751650D patent/BE751650A/fr unknown
- 1970-06-09 IL IL34702A patent/IL34702A/xx unknown
- 1970-06-15 ES ES380780A patent/ES380780A1/es not_active Expired
- 1970-06-18 NO NO2368/70A patent/NO125850B/no unknown
- 1970-06-25 DE DE2031359A patent/DE2031359C3/de not_active Expired
- 1970-07-02 FI FI701872A patent/FI50244C/fi active
- 1970-07-03 AT AT603170A patent/AT297729B/de not_active IP Right Cessation
- 1970-07-15 NL NL707010481A patent/NL142682B/xx unknown
- 1970-07-16 CH CH1093670A patent/CH511244A/fr not_active IP Right Cessation
- 1970-07-16 JP JP45062507A patent/JPS4932541B1/ja active Pending
- 1970-07-17 FR FR7026481A patent/FR2059529B1/fr not_active Expired
- 1970-07-17 SE SE09952/70A patent/SE358394B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2059529B1 (fr) | 1973-12-21 |
| CH511244A (fr) | 1971-08-15 |
| ES380780A1 (es) | 1972-09-16 |
| NL7010481A (fr) | 1971-01-20 |
| SE358394B (fr) | 1973-07-30 |
| AT297729B (de) | 1972-04-10 |
| NL142682B (nl) | 1974-07-15 |
| IL34702A0 (en) | 1970-08-19 |
| DE2031359B2 (de) | 1975-02-20 |
| DE2031359A1 (de) | 1971-02-04 |
| JPS4932541B1 (fr) | 1974-08-31 |
| BE751650A (fr) | 1970-11-16 |
| ZA703809B (en) | 1971-01-27 |
| FI50244B (fr) | 1975-09-30 |
| FI50244C (fi) | 1976-01-12 |
| FR2059529A1 (fr) | 1971-06-04 |
| IL34702A (en) | 1972-12-29 |
| DE2031359C3 (de) | 1975-10-02 |
| GB1265134A (fr) | 1972-03-01 |
| BR6914929D0 (pt) | 1973-04-19 |
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