NO122269B - - Google Patents
Download PDFInfo
- Publication number
- NO122269B NO122269B NO165942A NO16594266A NO122269B NO 122269 B NO122269 B NO 122269B NO 165942 A NO165942 A NO 165942A NO 16594266 A NO16594266 A NO 16594266A NO 122269 B NO122269 B NO 122269B
- Authority
- NO
- Norway
- Prior art keywords
- tablet
- tablets
- abrasive
- production
- melting
- Prior art date
Links
- 239000003826 tablet Substances 0.000 claims description 75
- 239000008187 granular material Substances 0.000 claims description 21
- 238000007906 compression Methods 0.000 claims description 17
- 230000006835 compression Effects 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- 238000002844 melting Methods 0.000 claims description 14
- 230000035515 penetration Effects 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 10
- 239000003082 abrasive agent Substances 0.000 claims description 8
- PRBORDFJHHAISJ-UHFFFAOYSA-N tybamate Chemical compound CCCCNC(=O)OCC(C)(CCC)COC(N)=O PRBORDFJHHAISJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000011149 active material Substances 0.000 claims description 5
- 239000000853 adhesive Substances 0.000 claims description 5
- 230000001070 adhesive effect Effects 0.000 claims description 5
- 239000001506 calcium phosphate Substances 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 3
- 239000000347 magnesium hydroxide Substances 0.000 claims description 3
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 3
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 3
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 3
- 239000007891 compressed tablet Substances 0.000 claims description 2
- 229960002560 tybamate Drugs 0.000 description 6
- 239000001913 cellulose Substances 0.000 description 5
- 229920002678 cellulose Polymers 0.000 description 5
- 239000002023 wood Substances 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- JWDYCNIAQWPBHD-UHFFFAOYSA-N 1-(2-methylphenyl)glycerol Chemical compound CC1=CC=CC=C1OCC(O)CO JWDYCNIAQWPBHD-UHFFFAOYSA-N 0.000 description 2
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- -1 2-methyl-2-propyl-1,3-propanediol-dicarbamate-aluminum hydroxide Chemical compound 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000007931 coated granule Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229960000816 magnesium hydroxide Drugs 0.000 description 1
- 235000012254 magnesium hydroxide Nutrition 0.000 description 1
- 229960003861 mephenesin Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US513094A US3395211A (en) | 1965-12-10 | 1965-12-10 | Tableting process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO122269B true NO122269B (fr) | 1971-06-07 |
Family
ID=24041866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO165942A NO122269B (fr) | 1965-12-10 | 1966-12-09 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3395211A (fr) |
| JP (1) | JPS4522959B1 (fr) |
| DE (1) | DE1617389A1 (fr) |
| DK (1) | DK118420B (fr) |
| FR (1) | FR1499681A (fr) |
| GB (1) | GB1113299A (fr) |
| NO (1) | NO122269B (fr) |
| SE (1) | SE305509B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9720061D0 (en) * | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
| WO1999052491A1 (fr) * | 1998-04-08 | 1999-10-21 | Kyowa Hakko Kogyo Co., Ltd. | Comprimes et procede de fabrication correspondant |
| MY157620A (en) * | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
| GB0714670D0 (en) * | 2007-07-27 | 2007-09-05 | Ineos Healthcare Ltd | Use |
| GB0720220D0 (en) * | 2007-10-16 | 2007-11-28 | Ineos Healthcare Ltd | Compound |
| GB0913525D0 (en) | 2009-08-03 | 2009-09-16 | Ineos Healthcare Ltd | Method |
| GB201001779D0 (en) | 2010-02-04 | 2010-03-24 | Ineos Healthcare Ltd | Composition |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3096248A (en) * | 1959-04-06 | 1963-07-02 | Rexall Drug & Chemical Company | Method of making an encapsulated tablet |
| US3042531A (en) * | 1959-12-09 | 1962-07-03 | Leslie Salt Company | Method of making a compressed tablet |
| US3116204A (en) * | 1961-11-09 | 1963-12-31 | Merck & Co Inc | Pharmaceutical compositions and method of preparing the same |
| US3134719A (en) * | 1962-04-05 | 1964-05-26 | American Cyanamid Co | Calcium phosphates in tablet compressing |
| US3175948A (en) * | 1963-01-10 | 1965-03-30 | Hoffmann La Roche | Multivitamin tablets and premixes |
| US3293132A (en) * | 1963-03-25 | 1966-12-20 | Merck & Co Inc | Spray dried vitamin compositions and method of preparation |
| US3332848A (en) * | 1963-07-10 | 1967-07-25 | Hoffmann La Roche | Microcrystalline cellulose with starch in niacinamide ascorbic acid tablet granulations |
| US3344030A (en) * | 1964-06-15 | 1967-09-26 | American Home Prod | Reinforced directly compressed nongranulated pharmaceutical crystalline lactose tables |
-
1965
- 1965-12-10 US US513094A patent/US3395211A/en not_active Expired - Lifetime
-
1966
- 1966-11-04 GB GB49515/66A patent/GB1113299A/en not_active Expired
- 1966-11-09 FR FR83129A patent/FR1499681A/fr not_active Expired
- 1966-11-12 DE DE19661617389 patent/DE1617389A1/de active Pending
- 1966-11-21 JP JP7621666A patent/JPS4522959B1/ja active Pending
- 1966-11-23 SE SE16043/66A patent/SE305509B/xx unknown
- 1966-11-25 DK DK611766AA patent/DK118420B/da unknown
- 1966-12-09 NO NO165942A patent/NO122269B/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US3395211A (en) | 1968-07-30 |
| DE1617389A1 (de) | 1970-06-25 |
| SE305509B (fr) | 1968-10-28 |
| JPS4522959B1 (fr) | 1970-08-03 |
| GB1113299A (en) | 1968-05-08 |
| DK118420B (da) | 1970-08-17 |
| FR1499681A (fr) | 1967-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10085945B2 (en) | Natural lubricant for direct compression and method for preparing natural tablet using the same | |
| DE69915718T2 (de) | Fliessfähige, direktverpressbare Stärke als Bindemittel, Sprengmittel und Füllstoff für Presstabletten und Hartgelatinkapseln | |
| US3344030A (en) | Reinforced directly compressed nongranulated pharmaceutical crystalline lactose tables | |
| JPH03236326A (ja) | 直接圧縮コレスチラミン錠剤及びその無溶剤被覆物 | |
| EP0210661B1 (fr) | Compositions anhydres granulaires à base de phosphate dicalcique utilisables pour la préparation directe de tablettes comprimées | |
| NO122269B (fr) | ||
| CN108926524B (zh) | 一种胶类产品速溶块及其制备方法 | |
| US3836618A (en) | Process for the uniform distribution of a drug on a granulated base | |
| US3305447A (en) | Tabletting sugar and method of preparing same | |
| Adeoye et al. | Evaluation of coprocessed disintegrants produced from tapioca starch and mannitol in orally disintegrating paracetamol tablet | |
| Whiteman et al. | The evaluation of six lactose-based materials as direct compression tablet excipients | |
| DK172002B1 (da) | Tabletmateriale og derudfra fremstillet tablet | |
| US5534555A (en) | Tableting excipient | |
| Vezin et al. | Adjustment of precompression force to reduce mixing‐time dependence of tablet tensile strength | |
| SU1687022A3 (ru) | Способ получени таблеток никорандила | |
| US4251518A (en) | Method of preparing readily disintegrable pharmaceutical compositions | |
| US6455069B1 (en) | Directly compressible starch as enhancer of properties of excipients when used as binder and disintegrant for compression tablets | |
| Garr et al. | Evaluation of sorghum starch as a tablet excipient | |
| US3493659A (en) | Compositions and process for the production thereof | |
| NO832446L (no) | Fremgangsmaate ved fremstilling av tabletter. | |
| US4347235A (en) | Water-soluble tablet | |
| Malkowska et al. | Effect of re-compression on the properties of tablets prepared by moist granulation | |
| US4007052A (en) | Preparation of adjuvant-free fructose tablets | |
| KR101429331B1 (ko) | 이부프로펜 나트륨 정제 및 이부프로펜 나트륨을 포함하는 제약 조성물의 제조 방법 | |
| DE2207633A1 (de) | Reagenztabletten und verfahren zur herstellung derselben |