GB1113299A - Tablets - Google Patents
TabletsInfo
- Publication number
- GB1113299A GB1113299A GB49515/66A GB4951566A GB1113299A GB 1113299 A GB1113299 A GB 1113299A GB 49515/66 A GB49515/66 A GB 49515/66A GB 4951566 A GB4951566 A GB 4951566A GB 1113299 A GB1113299 A GB 1113299A
- Authority
- GB
- United Kingdom
- Prior art keywords
- parts
- compression force
- lactose
- starch
- low melting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compressed tablets of pharmaceutical materials which are low melting or adhesive in nature and are not readily compressed by standard procedures, may be moulded by compression under a low compression force e.g. of 2 to 8 tons per sq. inch, by a punch within a die cavity which is subjected to a cleaning operation by the alternating sequential production therein of a tablet from an abrasive material under a high compression force e.g. 15 to 25 tons per sq. in. Preferably the low compression force is achieved with a punch penetration into the cavity of up to 1/8 in., and the high compression force with a penetration of at least 3/8 in. Preferably the process is operated on a multiple cavity rotary tablet press provided with a hopper for each of the materials and whereby one tablet of each material is produced from each die for each complete revolution of the head. The abrasive material is preferably one or more of lactose, wood, cellulose, magnesium hydroxide, tricalcium phosphate, and dicalcium phosphate. The low melting material may be anhydrose lactose with stated combinations and proportions of wood cellulose, magnesium stearate and magnesium hydroxide or may be tricalcium phosphate with lactose, starch, acacia and magnesium stearate. A suitable granulation comprises, in weight proportions, at least 50% of low melting material, 10-30% filler, 5 to 20% disintegrating agent, 2-15% binding agent and 1-5% lubricant. In a preferred tybamate granulation formulation, 67 parts thereof were coated with 3.5 parts gelatin followed by admixture with 13 parts wood cellulose and further coating with 1.5% of starch from a 5% concentration paste; the granules thus obtained were dried and admixed with 3 parts wood cellulose, 10.5 parts starch and 1.5 parts stearic acid. Suitable suppository granulations may contain a bismuth salt, benzocain and meprobamate with polyethylene glycol and a filler; sodium bicarbonate and sodium biophosphate may be contained in efferescent laxative suppository compositions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US513094A US3395211A (en) | 1965-12-10 | 1965-12-10 | Tableting process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1113299A true GB1113299A (en) | 1968-05-08 |
Family
ID=24041866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB49515/66A Expired GB1113299A (en) | 1965-12-10 | 1966-11-04 | Tablets |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3395211A (en) |
| JP (1) | JPS4522959B1 (en) |
| DE (1) | DE1617389A1 (en) |
| DK (1) | DK118420B (en) |
| FR (1) | FR1499681A (en) |
| GB (1) | GB1113299A (en) |
| NO (1) | NO122269B (en) |
| SE (1) | SE305509B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9720061D0 (en) * | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
| WO1999052491A1 (en) * | 1998-04-08 | 1999-10-21 | Kyowa Hakko Kogyo Co., Ltd. | Tablet manufacturing method and tablet |
| MY157620A (en) * | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
| GB0714670D0 (en) * | 2007-07-27 | 2007-09-05 | Ineos Healthcare Ltd | Use |
| GB0720220D0 (en) * | 2007-10-16 | 2007-11-28 | Ineos Healthcare Ltd | Compound |
| GB0913525D0 (en) | 2009-08-03 | 2009-09-16 | Ineos Healthcare Ltd | Method |
| GB201001779D0 (en) | 2010-02-04 | 2010-03-24 | Ineos Healthcare Ltd | Composition |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3096248A (en) * | 1959-04-06 | 1963-07-02 | Rexall Drug & Chemical Company | Method of making an encapsulated tablet |
| US3042531A (en) * | 1959-12-09 | 1962-07-03 | Leslie Salt Company | Method of making a compressed tablet |
| US3116204A (en) * | 1961-11-09 | 1963-12-31 | Merck & Co Inc | Pharmaceutical compositions and method of preparing the same |
| US3134719A (en) * | 1962-04-05 | 1964-05-26 | American Cyanamid Co | Calcium phosphates in tablet compressing |
| US3175948A (en) * | 1963-01-10 | 1965-03-30 | Hoffmann La Roche | Multivitamin tablets and premixes |
| US3293132A (en) * | 1963-03-25 | 1966-12-20 | Merck & Co Inc | Spray dried vitamin compositions and method of preparation |
| US3332848A (en) * | 1963-07-10 | 1967-07-25 | Hoffmann La Roche | Microcrystalline cellulose with starch in niacinamide ascorbic acid tablet granulations |
| US3344030A (en) * | 1964-06-15 | 1967-09-26 | American Home Prod | Reinforced directly compressed nongranulated pharmaceutical crystalline lactose tables |
-
1965
- 1965-12-10 US US513094A patent/US3395211A/en not_active Expired - Lifetime
-
1966
- 1966-11-04 GB GB49515/66A patent/GB1113299A/en not_active Expired
- 1966-11-09 FR FR83129A patent/FR1499681A/en not_active Expired
- 1966-11-12 DE DE19661617389 patent/DE1617389A1/en active Pending
- 1966-11-21 JP JP7621666A patent/JPS4522959B1/ja active Pending
- 1966-11-23 SE SE16043/66A patent/SE305509B/xx unknown
- 1966-11-25 DK DK611766AA patent/DK118420B/en unknown
- 1966-12-09 NO NO165942A patent/NO122269B/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US3395211A (en) | 1968-07-30 |
| DE1617389A1 (en) | 1970-06-25 |
| SE305509B (en) | 1968-10-28 |
| NO122269B (en) | 1971-06-07 |
| JPS4522959B1 (en) | 1970-08-03 |
| DK118420B (en) | 1970-08-17 |
| FR1499681A (en) | 1967-10-27 |
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