NL8902406A - Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit. - Google Patents

Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit. Download PDF

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Publication number
NL8902406A
NL8902406A NL8902406A NL8902406A NL8902406A NL 8902406 A NL8902406 A NL 8902406A NL 8902406 A NL8902406 A NL 8902406A NL 8902406 A NL8902406 A NL 8902406A NL 8902406 A NL8902406 A NL 8902406A
Authority
NL
Netherlands
Prior art keywords
thrombin
substrate
plasma
process according
amount
Prior art date
Application number
NL8902406A
Other languages
English (en)
Dutch (nl)
Original Assignee
Hendrik Coenraad Hemker Prof D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hendrik Coenraad Hemker Prof D filed Critical Hendrik Coenraad Hemker Prof D
Priority to NL8902406A priority Critical patent/NL8902406A/nl
Priority to EP90202509A priority patent/EP0420332B1/fr
Priority to DK90202509.7T priority patent/DK0420332T3/da
Priority to DE69018910T priority patent/DE69018910T2/de
Priority to ES90202509T priority patent/ES2072970T3/es
Priority to AT90202509T priority patent/ATE121792T1/de
Priority to US07/588,924 priority patent/US5192689A/en
Priority to JP02260273A priority patent/JP3137261B2/ja
Publication of NL8902406A publication Critical patent/NL8902406A/nl

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G01N2333/8128—Antithrombin III
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NL8902406A 1989-09-27 1989-09-27 Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit. NL8902406A (nl)

Priority Applications (8)

Application Number Priority Date Filing Date Title
NL8902406A NL8902406A (nl) 1989-09-27 1989-09-27 Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit.
EP90202509A EP0420332B1 (fr) 1989-09-27 1990-09-21 Procédé de détermination du potentiel de thrombine endogène dans le plasma ou le sang, et jeu de réchange pour son utilisation dans cette méthode
DK90202509.7T DK0420332T3 (da) 1989-09-27 1990-09-21 Fremgangsmåde til bestemmelse af det endogene trombinpotentiale af plasma og blod, samt et kit til anvendelse ved fremgangsmåden
DE69018910T DE69018910T2 (de) 1989-09-27 1990-09-21 Verfahren zur Bestimmung des endogenen Thrombinpotentials von Plasma und Blut und Reagenziensatz zur Verwendung in besagtem Verfahren.
ES90202509T ES2072970T3 (es) 1989-09-27 1990-09-21 Metodo para determinar el potencial de trombina endogeno del plasma y de la sangre, y tambien un equipo para su uso en dicho metodo.
AT90202509T ATE121792T1 (de) 1989-09-27 1990-09-21 Verfahren zur bestimmung des endogenen thrombinpotentials von plasma und blut und reagenziensatz zur verwendung in besagtem verfahren.
US07/588,924 US5192689A (en) 1989-09-27 1990-09-27 Method for determining the endogenous thrombin potential of plasma and blood
JP02260273A JP3137261B2 (ja) 1989-09-27 1990-09-27 血しょうおよび血液の内因性トロンビンポテンシャルの測定方法と同方法に使用するキット

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8902406 1989-09-27
NL8902406A NL8902406A (nl) 1989-09-27 1989-09-27 Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit.

Publications (1)

Publication Number Publication Date
NL8902406A true NL8902406A (nl) 1991-04-16

Family

ID=19855364

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8902406A NL8902406A (nl) 1989-09-27 1989-09-27 Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit.

Country Status (8)

Country Link
US (1) US5192689A (fr)
EP (1) EP0420332B1 (fr)
JP (1) JP3137261B2 (fr)
AT (1) ATE121792T1 (fr)
DE (1) DE69018910T2 (fr)
DK (1) DK0420332T3 (fr)
ES (1) ES2072970T3 (fr)
NL (1) NL8902406A (fr)

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EP0509086B1 (fr) * 1990-11-05 1995-04-12 Dade Produktions AG Procede de determination de la concentration d'anticoagulants
DE4203980A1 (de) * 1992-02-11 1993-08-12 Max Planck Gesellschaft Verfahren zur bestimmung von hirudin und synthetischen thrombininhibitoren
AT397391B (de) * 1992-05-15 1994-03-25 Immuno Ag Verwendung von prothrombinfragmenten
EP0585504A1 (fr) * 1992-09-04 1994-03-09 Pentapharm A.G. Activateur de prothrombine dépendant de phospholipides et son application dans les tests pour lupus anticoagulants
EP0802986B1 (fr) 1995-01-10 2001-09-19 Hendrik Coenraad Hemker Procedes pour la determination du potentiel thrombine endogene (etp), et substrats pour thrombine utilises dans ces procedes
DE19533817C2 (de) * 1995-09-13 1999-12-09 Max Planck Gesellschaft Komplex-gebundene Hemmstoffe aktivierbarer Stoffwechselenzyme als molekulare Marker zur Diagnostik und Therapieüberwachung
SE9600216D0 (sv) * 1996-01-18 1996-01-18 Hans Arne Hansson Styrning av läkningsprocesser
US6740496B1 (en) 1999-03-04 2004-05-25 Synapse B.V. Determination of biologically active forms of proteolytic enzymes
AUPP971299A0 (en) 1999-04-12 1999-05-06 South Eastern Sydney Area Health Service Procoagulant assay
US6645768B1 (en) * 2000-10-27 2003-11-11 Biomerieux, Inc. Reagent and kit for determining global coagulability and hemostatic potential
US6743596B1 (en) 2000-10-27 2004-06-01 Biomerieux, Inc. Method of determining global coagulability hemostatic potential
EP1367135A1 (fr) * 2002-05-29 2003-12-03 Pentapharm AG Procédé amélioré pour l'évaluation de formation de thrombin dans plasma sanguine
DE10360628A1 (de) * 2003-12-19 2005-07-21 Dade Behring Marburg Gmbh Kontrollplasma für Thrombinaktivitätstests
GB0402719D0 (en) * 2004-02-07 2004-03-10 Royal College Of Surgeons Ie A method of detecting incomplete inhibition of enzymes in individuals undergoing enzyme inhibitor therapy
CA2566411A1 (fr) * 2004-05-11 2005-11-24 Heptest Laboratories, Inc. Compositions, kit et procede en une etape permettant de surveiller des composes possedant des activites d'antifacteur xa et/ou d'antifacteur iia
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
DE102004059055A1 (de) 2004-12-07 2006-06-08 Dade Behring Marburg Gmbh Verfahren zur automatischen Bestimmung des endogenen Thrombinpotenzials
JP4931826B2 (ja) 2005-01-07 2012-05-16 スティヒティング・カトリーケ・ユニフェルジテイト 止血アッセイ
DE102005003145B4 (de) 2005-01-21 2006-10-19 Dade Behring Marburg Gmbh Stablies, chromogenes Flüssigreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests
WO2006088741A2 (fr) * 2005-02-16 2006-08-24 The Board Of Trustees Of The University Of Illinois Procoagulant universel
DE102005008066A1 (de) 2005-02-22 2006-08-24 Haemosys Gmbh Verfahren zur Bestimmung der Gesamtgerinnungsaktivität einer Blut- oder Plasmaprobe
WO2006096345A2 (fr) * 2005-03-04 2006-09-14 The Board Of Trustees Of The University Of Illinois Modulateur de coagulation et de cascades fibrinolytiques
CN101657545A (zh) 2005-12-27 2010-02-24 麦克马斯特大学 使用包括经间隔子附着于大分子的底物的修饰的底物的酶测量分析
US9091700B2 (en) 2005-12-27 2015-07-28 Mcmaster University Modified peptide substrate
DE102006035899A1 (de) 2006-07-31 2008-02-07 Dade Behring Marburg Gmbh Polysacharid-Peptid-Konjugate zur Verwendung als Thrombinsubstrate
CN101221188B (zh) * 2007-01-12 2012-04-18 上海太阳生物技术有限公司 临床检验凝血酶时间(tt)测定体外诊断试剂盒
DE102007017906A1 (de) 2007-04-17 2008-10-23 Dade Behring Marburg Gmbh Verfahren zur Bestimmung der Reaktions-Lag-Phase in einer analytabhängigen Reaktion
WO2009046194A2 (fr) * 2007-10-05 2009-04-09 The Board Of Trustees Of The University Of Illinois Produit d'étanchéité de fibrine
US20100297257A1 (en) * 2007-11-09 2010-11-25 National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) Anticoagulant antagonist and hemophillia procoagulant
DE102007062323A1 (de) 2007-12-21 2009-06-25 Siemens Healthcare Diagnostics Products Gmbh Langzeitstabiles Thromboplastin-Reagenz
WO2009142744A2 (fr) * 2008-05-20 2009-11-26 The University Of Vermont And State Agriculture College Prédiction du risque hémostatique en fonction de la composition du plasma
US8293493B2 (en) * 2010-01-27 2012-10-23 Adventist Health System/Sunbelt, Inc. Thrombin generation determination method
EP2395354A1 (fr) 2010-06-10 2011-12-14 Siemens Healthcare Diagnostics Products GmbH Test d'activité homogène destiné à la détermination de réactions enzymatiques
CN107870246B (zh) * 2010-09-20 2021-04-09 Q-塞拉有限公司 血清制备
EP3228714B1 (fr) 2010-12-14 2019-03-27 Stichting Katholieke Universiteit Dosage de l'hémostase basé sur la chimioluminescence
US9561300B2 (en) 2011-09-26 2017-02-07 Yes, Inc. Hemostatic compositions and dressings for bleeding
WO2013056116A1 (fr) * 2011-10-12 2013-04-18 The Trustees Of Columbia University In The City Of New York Pansement hémostatique pour saignement artériel
EP2677037B1 (fr) 2012-06-21 2016-04-13 Synapse B.V. Mesure simultanée de la génération de thrombine et résistance des caillots dans du plasma et du sang entier
WO2014098056A1 (fr) * 2012-12-18 2014-06-26 第一三共株式会社 Procédé de mesure de la production de thrombine
WO2015013495A1 (fr) * 2013-07-26 2015-01-29 The University Of North Carolina At Chapel Hill Procédés et compositions permettant la détection d'inhibiteurs de coagulation
JP7009998B2 (ja) 2016-01-29 2022-01-26 ソニーグループ株式会社 血液凝固系解析装置、血液凝固系解析システム、血液凝固系解析方法及び血液凝固系解析装置用パラメーターの決定方法
EP3642631B1 (fr) 2017-06-20 2022-03-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés permettant de diagnostiquer les patients souffrant d'insuffisance cardiaque décompensée aiguë (adhf) présentent un état d'hypercoagulabilité
EP3489692A1 (fr) 2017-11-28 2019-05-29 Siemens Healthcare Diagnostics Products GmbH Réactif pour le temps de prothrombine contenant un chélateur du fer
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WO2022133109A1 (fr) * 2020-12-16 2022-06-23 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions et méthodes destinées à traiter et prévenir un empoisonnement par du venin
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Also Published As

Publication number Publication date
DE69018910D1 (de) 1995-06-01
EP0420332A3 (en) 1991-05-08
DK0420332T3 (da) 1995-07-03
US5192689A (en) 1993-03-09
ES2072970T3 (es) 1995-08-01
ATE121792T1 (de) 1995-05-15
DE69018910T2 (de) 1995-08-24
JP3137261B2 (ja) 2001-02-19
EP0420332A2 (fr) 1991-04-03
JPH03236798A (ja) 1991-10-22
EP0420332B1 (fr) 1995-04-26

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