DK0420332T3 - Fremgangsmåde til bestemmelse af det endogene trombinpotentiale af plasma og blod, samt et kit til anvendelse ved fremgangsmåden - Google Patents
Fremgangsmåde til bestemmelse af det endogene trombinpotentiale af plasma og blod, samt et kit til anvendelse ved fremgangsmådenInfo
- Publication number
- DK0420332T3 DK0420332T3 DK90202509.7T DK90202509T DK0420332T3 DK 0420332 T3 DK0420332 T3 DK 0420332T3 DK 90202509 T DK90202509 T DK 90202509T DK 0420332 T3 DK0420332 T3 DK 0420332T3
- Authority
- DK
- Denmark
- Prior art keywords
- thrombin
- etp
- determining
- sample
- conversion
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/75—Fibrin; Fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8121—Serpins
- G01N2333/8128—Antithrombin III
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8902406A NL8902406A (nl) | 1989-09-27 | 1989-09-27 | Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit. |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0420332T3 true DK0420332T3 (da) | 1995-07-03 |
Family
ID=19855364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90202509.7T DK0420332T3 (da) | 1989-09-27 | 1990-09-21 | Fremgangsmåde til bestemmelse af det endogene trombinpotentiale af plasma og blod, samt et kit til anvendelse ved fremgangsmåden |
Country Status (8)
Country | Link |
---|---|
US (1) | US5192689A (da) |
EP (1) | EP0420332B1 (da) |
JP (1) | JP3137261B2 (da) |
AT (1) | ATE121792T1 (da) |
DE (1) | DE69018910T2 (da) |
DK (1) | DK0420332T3 (da) |
ES (1) | ES2072970T3 (da) |
NL (1) | NL8902406A (da) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69108896T2 (de) * | 1990-11-05 | 1995-08-24 | Baxter Diagnostics Inc | Verfahren zur bestimmung der konzentration von antikoagulantien. |
DE4203980A1 (de) * | 1992-02-11 | 1993-08-12 | Max Planck Gesellschaft | Verfahren zur bestimmung von hirudin und synthetischen thrombininhibitoren |
AT397391B (de) * | 1992-05-15 | 1994-03-25 | Immuno Ag | Verwendung von prothrombinfragmenten |
EP0585504A1 (en) * | 1992-09-04 | 1994-03-09 | Pentapharm A.G. | Phospholipid dependant prothrombin activator and its use in lupus anticoagulant testing |
DE69615339T2 (de) * | 1995-01-10 | 2002-07-04 | Hemker Hendrik Coenraad | Verfahren zum nachweis des endogenen thrombin-potentials und thrombin substrate zur verwendung in diesen verfahren |
DE19533817C2 (de) * | 1995-09-13 | 1999-12-09 | Max Planck Gesellschaft | Komplex-gebundene Hemmstoffe aktivierbarer Stoffwechselenzyme als molekulare Marker zur Diagnostik und Therapieüberwachung |
SE9600216D0 (sv) * | 1996-01-18 | 1996-01-18 | Hans Arne Hansson | Styrning av läkningsprocesser |
US6740496B1 (en) | 1999-03-04 | 2004-05-25 | Synapse B.V. | Determination of biologically active forms of proteolytic enzymes |
AUPP971299A0 (en) * | 1999-04-12 | 1999-05-06 | South Eastern Sydney Area Health Service | Procoagulant assay |
US6743596B1 (en) | 2000-10-27 | 2004-06-01 | Biomerieux, Inc. | Method of determining global coagulability hemostatic potential |
US6645768B1 (en) * | 2000-10-27 | 2003-11-11 | Biomerieux, Inc. | Reagent and kit for determining global coagulability and hemostatic potential |
EP1367135A1 (en) | 2002-05-29 | 2003-12-03 | Pentapharm AG | Improved method for the assessment of thrombin formation in blood or plasma |
DE10360628A1 (de) * | 2003-12-19 | 2005-07-21 | Dade Behring Marburg Gmbh | Kontrollplasma für Thrombinaktivitätstests |
GB0402719D0 (en) * | 2004-02-07 | 2004-03-10 | Royal College Of Surgeons Ie | A method of detecting incomplete inhibition of enzymes in individuals undergoing enzyme inhibitor therapy |
EP1745145A4 (en) * | 2004-05-11 | 2008-03-26 | Heptest Lab Inc | COMPOSITIONS, KIT AND METHOD IN ONE STEP FOR MONITORING COMPOUNDS HAVING XA AND / OR ANTIFACTOR IIA ANTIFACTOR ACTIVITIES |
US7148067B2 (en) * | 2004-08-31 | 2006-12-12 | The Board Of Trustees Of The University Of Illinois | Thromboplastin reagents |
DE102004059055A1 (de) * | 2004-12-07 | 2006-06-08 | Dade Behring Marburg Gmbh | Verfahren zur automatischen Bestimmung des endogenen Thrombinpotenzials |
DE602006018577D1 (de) | 2005-01-07 | 2011-01-13 | Stichting Katholieke Univ | Blutstillungstest |
DE102005003145B4 (de) * | 2005-01-21 | 2006-10-19 | Dade Behring Marburg Gmbh | Stablies, chromogenes Flüssigreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests |
CN101151533A (zh) * | 2005-02-16 | 2008-03-26 | 伊利诺斯大学理事会 | 基于金属螯合脂质的促凝血剂 |
DE102005008066A1 (de) | 2005-02-22 | 2006-08-24 | Haemosys Gmbh | Verfahren zur Bestimmung der Gesamtgerinnungsaktivität einer Blut- oder Plasmaprobe |
ATE505488T1 (de) * | 2005-03-04 | 2011-04-15 | Univ Illinois | Modulator von coagulationskaskaden und fibrinolytischen kaskaden |
US9091700B2 (en) | 2005-12-27 | 2015-07-28 | Mcmaster University | Modified peptide substrate |
EP3660162A1 (en) | 2005-12-27 | 2020-06-03 | McMaster University | Enzyme measurement assay using a modified substrate comprising a substrate attached to a macromolecule via a spacer |
DE102006035899A1 (de) | 2006-07-31 | 2008-02-07 | Dade Behring Marburg Gmbh | Polysacharid-Peptid-Konjugate zur Verwendung als Thrombinsubstrate |
CN101221188B (zh) * | 2007-01-12 | 2012-04-18 | 上海太阳生物技术有限公司 | 临床检验凝血酶时间(tt)测定体外诊断试剂盒 |
DE102007017906A1 (de) | 2007-04-17 | 2008-10-23 | Dade Behring Marburg Gmbh | Verfahren zur Bestimmung der Reaktions-Lag-Phase in einer analytabhängigen Reaktion |
WO2009046194A2 (en) * | 2007-10-05 | 2009-04-09 | The Board Of Trustees Of The University Of Illinois | Fibrin sealant |
WO2009061697A1 (en) * | 2007-11-09 | 2009-05-14 | The Board Of Trustees Of The University Of Illinois | Anticoagulant antagonist and hemophilia procoagulant |
DE102007062323A1 (de) | 2007-12-21 | 2009-06-25 | Siemens Healthcare Diagnostics Products Gmbh | Langzeitstabiles Thromboplastin-Reagenz |
US20090298103A1 (en) * | 2008-05-20 | 2009-12-03 | The University Of Vermont And State Agriculture College | Predicting hemostatic risk; dependence on plasma composition |
US8293493B2 (en) * | 2010-01-27 | 2012-10-23 | Adventist Health System/Sunbelt, Inc. | Thrombin generation determination method |
EP2395354A1 (de) | 2010-06-10 | 2011-12-14 | Siemens Healthcare Diagnostics Products GmbH | Homogener Aktivitätstest zur Bestimmung von enzymatischen Reaktionen |
RU2643957C2 (ru) * | 2010-09-20 | 2018-02-06 | Кью-Сера Пти Лтд | Получение сыворотки |
DK3228714T3 (da) | 2010-12-14 | 2019-06-17 | Stichting Katholieke Univ | Kemiluminescens-baseret hæmostase-assay |
WO2013048787A1 (en) | 2011-09-26 | 2013-04-04 | Yes, Inc. | Novel hemostatic compositions and dressings for bleeding |
WO2013056116A1 (en) * | 2011-10-12 | 2013-04-18 | The Trustees Of Columbia University In The City Of New York | Hemostatic dressing for arterial bleeding |
EP2677037B1 (en) | 2012-06-21 | 2016-04-13 | Synapse B.V. | Simultaneous measurement of thrombin generation and clot strength in plasma and whole blood |
US10266871B2 (en) | 2012-12-18 | 2019-04-23 | Daiichi Sankyo Company, Limited | Measurement method for thrombin production |
WO2015013495A1 (en) * | 2013-07-26 | 2015-01-29 | The University Of North Carolina At Chapel Hill | Methods and compositions for detecting coagulation inhibitors |
US10794896B2 (en) | 2016-01-29 | 2020-10-06 | Sony Corporation | Blood coagulation system examination module, blood coagulation system examination system, blood coagulation system examination method, and determination method of parameter for blood coagulation system examination module |
WO2018234308A1 (en) | 2017-06-20 | 2018-12-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS FOR IDENTIFYING IF PATIENTS WITH ACUTE CARDIAC DISEASE FAILURE (ICAD) HAVE A HYPERCOAGULABLE CONDITION |
EP3489692A1 (de) | 2017-11-28 | 2019-05-29 | Siemens Healthcare Diagnostics Products GmbH | Prothrombinzeit-reagenz enthaltend einen eisenchelator |
EP4004560A4 (en) * | 2019-07-31 | 2022-11-30 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | METHODS AND KITS FOR THROMBUS ORIGIN IDENTIFICATION AND POST-ISCHEMIC EVENT TREATMENT OPTIMIZATION |
WO2022133109A1 (en) * | 2020-12-16 | 2022-06-23 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for treating and preventing venom related poisoning |
EP4239338A1 (de) | 2022-03-03 | 2023-09-06 | Siemens Healthcare Diagnostics Products GmbH | Globaltest zur feststellung des status des blutgerinnungssystems |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4247454A (en) * | 1975-07-11 | 1981-01-27 | Ab Kabi | Novel chromogenic thrombin substrates |
US4169015A (en) * | 1975-07-11 | 1979-09-25 | Ab Kabi | Novel chromogenic thrombin substrates |
US4061625A (en) * | 1975-07-11 | 1977-12-06 | Ab Kabi | Novel chromogenic thrombin substrates |
US4289498A (en) * | 1979-01-08 | 1981-09-15 | Ortho Diagnostics, Inc. | One-stage prothrombin assay and compositions useful therein |
WO1982001377A1 (en) * | 1980-10-09 | 1982-04-29 | Lill Helmut | Method for determining a bm-antithrombin |
DE3244030A1 (de) * | 1982-11-27 | 1984-05-30 | Behringwerke Ag, 3550 Marburg | Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung |
US4594326A (en) * | 1983-05-09 | 1986-06-10 | Wade Stephen E | Time-integrated measurement for determining substances in biological fluids |
DE3407280A1 (de) * | 1984-02-28 | 1985-09-19 | Gödecke AG, 1000 Berlin | Testsatz zur bestimmung der aktivierten partiellen thromboplastinzeit (ptt) mit erhoehter heparinempfindlichkeit |
US4851336A (en) * | 1985-09-05 | 1989-07-25 | Yin E Thye | Composition, kit, and method for assaying heparinano a method for making the composition |
-
1989
- 1989-09-27 NL NL8902406A patent/NL8902406A/nl not_active Application Discontinuation
-
1990
- 1990-09-21 DE DE69018910T patent/DE69018910T2/de not_active Expired - Lifetime
- 1990-09-21 DK DK90202509.7T patent/DK0420332T3/da active
- 1990-09-21 EP EP90202509A patent/EP0420332B1/en not_active Expired - Lifetime
- 1990-09-21 AT AT90202509T patent/ATE121792T1/de not_active IP Right Cessation
- 1990-09-21 ES ES90202509T patent/ES2072970T3/es not_active Expired - Lifetime
- 1990-09-27 US US07/588,924 patent/US5192689A/en not_active Expired - Lifetime
- 1990-09-27 JP JP02260273A patent/JP3137261B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0420332B1 (en) | 1995-04-26 |
ATE121792T1 (de) | 1995-05-15 |
ES2072970T3 (es) | 1995-08-01 |
JP3137261B2 (ja) | 2001-02-19 |
EP0420332A3 (en) | 1991-05-08 |
EP0420332A2 (en) | 1991-04-03 |
DE69018910D1 (de) | 1995-06-01 |
US5192689A (en) | 1993-03-09 |
DE69018910T2 (de) | 1995-08-24 |
NL8902406A (nl) | 1991-04-16 |
JPH03236798A (ja) | 1991-10-22 |
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