NL8501198A - Nieuwe geneesmiddelen met antimicrobiele werking en werkwijze voor de bereiding ervan. - Google Patents
Nieuwe geneesmiddelen met antimicrobiele werking en werkwijze voor de bereiding ervan. Download PDFInfo
- Publication number
- NL8501198A NL8501198A NL8501198A NL8501198A NL8501198A NL 8501198 A NL8501198 A NL 8501198A NL 8501198 A NL8501198 A NL 8501198A NL 8501198 A NL8501198 A NL 8501198A NL 8501198 A NL8501198 A NL 8501198A
- Authority
- NL
- Netherlands
- Prior art keywords
- medicament
- acid
- oxytetracycline
- preparation
- organic acid
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 10
- 230000000845 anti-microbial effect Effects 0.000 title claims description 8
- 238000000034 method Methods 0.000 title claims description 7
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000004100 Oxytetracycline Substances 0.000 claims description 13
- 229960000625 oxytetracycline Drugs 0.000 claims description 13
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims description 13
- 235000019366 oxytetracycline Nutrition 0.000 claims description 13
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 8
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 claims description 8
- 229960000210 nalidixic acid Drugs 0.000 claims description 7
- 150000007524 organic acids Chemical class 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- KYGZCKSPAKDVKC-UHFFFAOYSA-N Oxolinic acid Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC2=C1OCO2 KYGZCKSPAKDVKC-UHFFFAOYSA-N 0.000 claims description 5
- 239000000969 carrier Substances 0.000 claims description 5
- 230000002195 synergetic effect Effects 0.000 claims description 5
- 230000002496 gastric effect Effects 0.000 claims description 4
- 229960000321 oxolinic acid Drugs 0.000 claims description 4
- 230000000241 respiratory effect Effects 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 description 8
- 244000309466 calf Species 0.000 description 6
- 241000607142 Salmonella Species 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 239000000890 drug combination Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 241000588748 Klebsiella Species 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 241000194017 Streptococcus Species 0.000 description 3
- 241000282887 Suidae Species 0.000 description 3
- 206010046793 Uterine inflammation Diseases 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000588807 Bordetella Species 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000004232 Enteritis Diseases 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 241000606860 Pasteurella Species 0.000 description 2
- 241000588769 Proteus <enterobacteria> Species 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000186779 Listeria monocytogenes Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 241000186064 Trueperella pyogenes Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 235000020346 chamomile tea Nutrition 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 210000002219 extraembryonic membrane Anatomy 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 244000000058 gram-negative pathogen Species 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000012009 microbiological test Methods 0.000 description 1
- HZVGIXIRNANSHU-UHFFFAOYSA-N naphthalene-1,2,3,4-tetrone Chemical compound C1=CC=C2C(=O)C(=O)C(=O)C(=O)C2=C1 HZVGIXIRNANSHU-UHFFFAOYSA-N 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU168284 | 1984-04-28 | ||
| HU841682A HU190963B (en) | 1984-04-28 | 1984-04-28 | Process for production of synergyc medical preparatives containing organic acids with oxitetracylin and antimicrobatic influence |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8501198A true NL8501198A (nl) | 1985-11-18 |
Family
ID=10955662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8501198A NL8501198A (nl) | 1984-04-28 | 1985-04-26 | Nieuwe geneesmiddelen met antimicrobiele werking en werkwijze voor de bereiding ervan. |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE902251A (it) |
| CH (1) | CH666817A5 (it) |
| DE (1) | DE3515214A1 (it) |
| ES (1) | ES8706028A1 (it) |
| FR (1) | FR2563433B1 (it) |
| HU (1) | HU190963B (it) |
| IT (1) | IT1200460B (it) |
| NL (1) | NL8501198A (it) |
| SE (1) | SE467445B (it) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU200917B (en) * | 1987-07-20 | 1990-09-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing pharmaceutical compositions comprising quinoline or naphthyridinecarboxylic acid and tetracycline derivatives as active ingredient |
| EP0951902A1 (en) * | 1998-03-31 | 1999-10-27 | Edmund J.H. Campion | A feed mixture |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH642850A5 (it) * | 1978-10-20 | 1984-05-15 | Ausonia Farma Srl | Composizioni farmaceutiche ad attivita antibatterica contro infezioni da germi gram-positivi e gram-negativi. |
-
1984
- 1984-04-28 HU HU841682A patent/HU190963B/hu not_active IP Right Cessation
-
1985
- 1985-04-22 BE BE1/011244A patent/BE902251A/fr not_active IP Right Cessation
- 1985-04-24 CH CH1750/85A patent/CH666817A5/de not_active IP Right Cessation
- 1985-04-26 SE SE8502039A patent/SE467445B/sv not_active IP Right Cessation
- 1985-04-26 NL NL8501198A patent/NL8501198A/nl not_active Application Discontinuation
- 1985-04-26 DE DE19853515214 patent/DE3515214A1/de not_active Withdrawn
- 1985-04-26 ES ES542611A patent/ES8706028A1/es not_active Expired
- 1985-04-26 IT IT20514/85A patent/IT1200460B/it active
- 1985-04-26 FR FR8506395A patent/FR2563433B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| HUT37349A (en) | 1985-12-28 |
| SE8502039D0 (sv) | 1985-04-26 |
| IT1200460B (it) | 1989-01-18 |
| ES8706028A1 (es) | 1987-06-01 |
| IT8520514A0 (it) | 1985-04-26 |
| SE8502039L (sv) | 1985-10-29 |
| FR2563433A1 (fr) | 1985-10-31 |
| CH666817A5 (de) | 1988-08-31 |
| SE467445B (sv) | 1992-07-20 |
| FR2563433B1 (fr) | 1988-12-02 |
| DE3515214A1 (de) | 1985-10-31 |
| HU190963B (en) | 1986-12-28 |
| BE902251A (fr) | 1985-10-22 |
| ES542611A0 (es) | 1987-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BV | The patent application has lapsed |