NL8302596A - Werkwijze voor de microbiologische 1,2-dehydrogenering van steroiden. - Google Patents
Werkwijze voor de microbiologische 1,2-dehydrogenering van steroiden. Download PDFInfo
- Publication number
- NL8302596A NL8302596A NL8302596A NL8302596A NL8302596A NL 8302596 A NL8302596 A NL 8302596A NL 8302596 A NL8302596 A NL 8302596A NL 8302596 A NL8302596 A NL 8302596A NL 8302596 A NL8302596 A NL 8302596A
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- NL
- Netherlands
- Prior art keywords
- dione
- pregn
- conversion
- steroid
- methyl
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- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012065 filter cake Substances 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 239000010699 lard oil Substances 0.000 description 1
- 238000000464 low-speed centrifugation Methods 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 229940078552 o-xylene Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000002897 organic nitrogen compounds Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000867 polyelectrolyte Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- 150000003130 pregnenes Chemical class 0.000 description 1
- QMYDVDBERNLWKB-UHFFFAOYSA-N propane-1,2-diol;hydrate Chemical compound O.CC(O)CO QMYDVDBERNLWKB-UHFFFAOYSA-N 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 235000015500 sitosterol Nutrition 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- BBNRSHIAFWOPAK-UHFFFAOYSA-L steroid d Chemical compound [Na+].[Na+].O1C2CC3C4CCC5CC(OS([O-])(=O)=O)C(OS([O-])(=O)=O)CC5(C)C4CCC3(C)C2C2(C)OC1(CCC)OC2CC1(C(C)C)CC1C BBNRSHIAFWOPAK-UHFFFAOYSA-L 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
- 235000016831 stigmasterol Nutrition 0.000 description 1
- 229940032091 stigmasterol Drugs 0.000 description 1
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 150000005671 trienes Chemical class 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/02—Dehydrogenating; Dehydroxylating
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40394982A | 1982-07-30 | 1982-07-30 | |
| US40394982 | 1982-07-30 | ||
| US06/436,552 US4524134A (en) | 1982-07-30 | 1982-10-25 | Process for preparing 1,2-dehydro steroids |
| US43655282 | 1982-10-25 | ||
| US47543783A | 1983-03-15 | 1983-03-15 | |
| US47543783 | 1983-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8302596A true NL8302596A (nl) | 1984-02-16 |
Family
ID=27410563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8302596A NL8302596A (nl) | 1982-07-30 | 1983-07-20 | Werkwijze voor de microbiologische 1,2-dehydrogenering van steroiden. |
Country Status (8)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2568908B1 (fr) * | 1984-08-10 | 1986-12-26 | Doris Dev Richesse Sous Marine | Plate-forme oscillante sur pieux flexibles pour travaux en mer |
| US5380839A (en) * | 1985-09-12 | 1995-01-10 | The Upjohn Company | Phenylpiperazinyl steroids |
| USRE35053E (en) * | 1985-09-12 | 1995-10-10 | The Upjohn Company | Amines useful in producing pharmaceutically active CNS compounds |
| US5099019A (en) * | 1985-09-12 | 1992-03-24 | Upjohn Company | Amines useful in producing pharmaceutically active CNS compounds |
| HU204305B (en) * | 1987-03-12 | 1991-12-30 | Upjohn Co | Process for 1,2-dehydrogenating 3-ketopregnen-21-esters with arthrobacter symplex or bacterium cyclooxydans |
| CN101346460B (zh) * | 2005-12-28 | 2014-05-07 | 味之素株式会社 | 干燥微生物菌体的制造方法 |
| HU227367B1 (en) * | 2007-09-11 | 2011-04-28 | Richter Gedeon Nyrt | Method for producing 6-hydroxymethyl-1,4-androstadiene-3,17-dion |
| NZ603107A (en) | 2008-05-28 | 2014-03-28 | Validus Biopharma Inc | Non-hormonal steroid modulators of nf-kb for treatment of disease |
| US20120178124A1 (en) | 2009-01-07 | 2012-07-12 | Mitsubishi Chemical Corporation | Sterol side chain-cleaving enzyme protein and use thereof |
| WO2011127048A2 (en) | 2010-04-05 | 2011-10-13 | Validus Biopharma | NON-HORMONAL STEROID MODULATORS OF NF-ĸB FOR TREATMENT OF DISEASE |
| WO2017004205A1 (en) | 2015-06-29 | 2017-01-05 | Reveragen Biopharma, Inc. | NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE |
| US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB883500A (en) * | 1958-09-15 | 1961-11-29 | Wisconsin Alumni Res Found | Improvements in a microbiological process for the preparation of steroids and ketones |
| FR1262182A (fr) * | 1960-07-01 | 1961-05-26 | Olin Mathieson | Procédé de déshydrogénation sélective du noyau a des stéroïdes |
| US3087864A (en) * | 1961-04-28 | 1963-04-30 | American Cyanamid Co | Process for the 1, 2-hydrogenation of steroids by the use of dried thalli |
| CH414063A (de) * | 1962-11-23 | 1966-05-31 | Eprova Ag | Röntgenkontrastmittel |
| US3360439A (en) * | 1964-08-19 | 1967-12-26 | Squibb & Sons Inc | Process for preparing 1-dehydro steroids |
| US3549498A (en) * | 1968-04-02 | 1970-12-22 | Squibb & Sons Inc | 11alpha-substituted steroids and process |
| FR2285137A1 (fr) * | 1974-09-18 | 1976-04-16 | Roussel Uclaf | Nouveaux derives steroides 17-spirosultines, les g-hydroxyacides correspondants, leur procede de preparation et leur application comme medicament |
| US4035236A (en) * | 1975-10-24 | 1977-07-12 | The Upjohn Company | Process for preparing 9α-hydroxyandrostenedione |
| US4041055A (en) * | 1975-11-17 | 1977-08-09 | The Upjohn Company | Process for the preparation of 17α-hydroxyprogesterones and corticoids from androstenes |
-
1983
- 1983-06-20 DE DE19833322120 patent/DE3322120A1/de active Granted
- 1983-06-27 GB GB08317422A patent/GB2123833B/en not_active Expired
- 1983-07-08 CH CH378483A patent/CH657871A5/de not_active IP Right Cessation
- 1983-07-15 DD DD25312383A patent/DD213242A5/de not_active IP Right Cessation
- 1983-07-20 NL NL8302596A patent/NL8302596A/nl active Search and Examination
- 1983-07-25 JP JP13453683A patent/JPH0614874B2/ja not_active Expired - Lifetime
- 1983-07-27 IE IE176783A patent/IE55533B1/en not_active IP Right Cessation
- 1983-07-29 FR FR8312564A patent/FR2531101B1/fr not_active Expired
-
1984
- 1984-02-01 GB GB08402640A patent/GB2131811B/en not_active Expired
-
1993
- 1993-09-14 JP JP5250926A patent/JPH0824596B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB8402640D0 (en) | 1984-03-07 |
| FR2531101B1 (fr) | 1985-11-15 |
| DE3322120C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-10-08 |
| IE831767L (en) | 1984-01-30 |
| DD213242A5 (de) | 1984-09-05 |
| GB8317422D0 (en) | 1983-07-27 |
| GB2131811A (en) | 1984-06-27 |
| IE55533B1 (en) | 1990-10-24 |
| GB2131811B (en) | 1986-06-11 |
| GB2123833A (en) | 1984-02-08 |
| DE3322120A1 (de) | 1984-02-02 |
| JPH0824596B2 (ja) | 1996-03-13 |
| JPH06225792A (ja) | 1994-08-16 |
| CH657871A5 (de) | 1986-09-30 |
| FR2531101A1 (fr) | 1984-02-03 |
| GB2123833B (en) | 1986-06-11 |
| JPS5939299A (ja) | 1984-03-03 |
| JPH0614874B2 (ja) | 1994-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| DNT | Communications of changes of names of applicants whose applications have been laid open to public inspection |
Free format text: PHARMACIA & UPJOHN COMPANY |
|
| BN | A decision not to publish the application has become irrevocable |