NL8120313A - Heterocyclische amidino-gesubstitueerde ureums en de farmaceutische toepassingen daarvan. - Google Patents

Heterocyclische amidino-gesubstitueerde ureums en de farmaceutische toepassingen daarvan. Download PDF

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Publication number
NL8120313A
NL8120313A NL8120313A NL8120313A NL8120313A NL 8120313 A NL8120313 A NL 8120313A NL 8120313 A NL8120313 A NL 8120313A NL 8120313 A NL8120313 A NL 8120313A NL 8120313 A NL8120313 A NL 8120313A
Authority
NL
Netherlands
Prior art keywords
acid addition
addition salts
pyridyl
lower alkoxy
quinoline
Prior art date
Application number
NL8120313A
Other languages
English (en)
Dutch (nl)
Original Assignee
Rorer Int Overseas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rorer Int Overseas filed Critical Rorer Int Overseas
Publication of NL8120313A publication Critical patent/NL8120313A/nl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL8120313A 1981-08-24 1981-08-24 Heterocyclische amidino-gesubstitueerde ureums en de farmaceutische toepassingen daarvan. NL8120313A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8101146 1981-08-24
PCT/US1981/001146 WO1983000627A1 (fr) 1981-08-24 1981-08-24 Urees heterocycliques a substitution amidino et leurs utilisations pharmaceutiques

Publications (1)

Publication Number Publication Date
NL8120313A true NL8120313A (nl) 1983-07-01

Family

ID=22161395

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8120313A NL8120313A (nl) 1981-08-24 1981-08-24 Heterocyclische amidino-gesubstitueerde ureums en de farmaceutische toepassingen daarvan.

Country Status (12)

Country Link
US (1) US4707478A (fr)
EP (1) EP0086775A4 (fr)
JP (1) JPS58501468A (fr)
AU (1) AU543834B2 (fr)
CA (1) CA1210394A (fr)
CH (1) CH656125A5 (fr)
DE (1) DE3152942T1 (fr)
DK (1) DK181583A (fr)
GB (1) GB2115419B (fr)
NL (1) NL8120313A (fr)
SE (1) SE452007B (fr)
WO (1) WO1983000627A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0306696B1 (fr) * 1987-08-04 1994-02-16 Ciba-Geigy Ag Guanidines substituées
CA2116621C (fr) * 1993-03-03 2001-07-24 Rene C. Gaudreault Agents anticancereux
US5750547A (en) * 1995-01-06 1998-05-12 Universite Laval Certain carbanate anti-cancer agents
AUPN193095A0 (en) * 1995-03-24 1995-04-27 Polychip Pharmaceuticals Pty Ltd Potassium ion channel blockers
AU2003295605A1 (en) 2002-11-19 2004-06-15 Achillion Pharmaceuticals, Inc. Substituted aryl thioureas and releated compounds; inhibitors of viral replication
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
CN114292225B (zh) * 2022-01-10 2023-07-11 万华化学集团股份有限公司 一种季铵型强碱性阴离子交换树脂及其催化制备甲基丙烯酸缩水甘油酯的方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1194835A (en) * 1966-07-07 1970-06-10 Wellcome Found Novel 1-Amidino-3-Phenyl-Urea Derivatives, the preparation thereof and Compositions containing the same
US3798269A (en) * 1968-08-05 1974-03-19 R Cutler Amidinoureas and amidinothioureas
US3984467A (en) * 1969-03-03 1976-10-05 Sterling Drug Inc. Anthelmintic 1-(substituted phenyl)-3-alkanimidoyl ureas
US3933794A (en) * 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
US4025652A (en) * 1975-03-31 1977-05-24 William H. Rorer, Inc. Amidinoureas
US4220658A (en) * 1972-09-22 1980-09-02 William H. Rorer, Inc. Treatment of hypertension with amidinoureas
US4060635A (en) * 1975-03-31 1977-11-29 William H. Rorer, Inc. Amidinoureas for treating diarrhea
US4009163A (en) * 1973-08-24 1977-02-22 Sterling Drug Inc. Amidinoureas and amidinothioureas
US4163022A (en) * 1975-02-03 1979-07-31 Cooper Laboratories, Inc. Carbamylguanidine antimicrobial compounds
US4088785A (en) * 1976-03-25 1978-05-09 William H. Rorer, Inc. Amidinoureas for the treatment of cardinascular disorders
US4058557A (en) * 1976-03-30 1977-11-15 William H. Rorer, Inc. Amidinoureas
US4178387A (en) * 1976-03-30 1979-12-11 William H. Rorer, Inc. Method for the treatment of arrhythmia
US4169155A (en) * 1976-03-30 1979-09-25 William H. Rorer, Inc. Method for treatment of gastrointestinal secretory and ulcerogenic disease conditions or symptoms in mammals
JPS53108970A (en) * 1977-03-07 1978-09-22 Yamanouchi Pharmaceut Co Ltd Novel guanidine derivative and its preparation
US4166860A (en) * 1977-10-11 1979-09-04 William H. Rorer, Inc. Imidazole amidinoureas for stimulating H2 -receptors
US4304786A (en) * 1978-09-14 1981-12-08 William H. Rorer, Inc. Amidinoureas
US4225315A (en) * 1978-11-13 1980-09-30 William H. Rorer, Inc. Triazinones from amidinoureas
DE2853220A1 (de) * 1978-12-09 1980-07-03 Hoechst Ag Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung
US4241087A (en) * 1979-04-02 1980-12-23 William H. Rorer, Inc. Dysmenorrhea treatment
US4340609A (en) * 1980-01-02 1982-07-20 William H. Rorer, Inc. Amidinourea derivative veterinary compositions for suppression of parasitemia
US4486439A (en) * 1981-08-24 1984-12-04 William H. Rorer, Inc. Treatment of coccidiosis

Also Published As

Publication number Publication date
SE8302283L (en) 1983-04-22
US4707478A (en) 1987-11-17
SE8302283D0 (sv) 1983-04-22
GB8310965D0 (en) 1983-05-25
WO1983000627A1 (fr) 1983-03-03
JPS58501468A (ja) 1983-09-01
CA1210394A (fr) 1986-08-26
CH656125A5 (en) 1986-06-13
DK181583D0 (da) 1983-04-25
DE3152942T1 (de) 1983-12-15
EP0086775A4 (fr) 1984-09-05
SE452007B (sv) 1987-11-09
DK181583A (da) 1983-04-25
GB2115419B (en) 1985-10-02
AU543834B2 (en) 1985-05-02
AU7539481A (en) 1983-03-08
EP0086775A1 (fr) 1983-08-31
GB2115419A (en) 1983-09-07

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BV The patent application has lapsed