NL8102269A - Tinverbindingen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke tinverbinding voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. - Google Patents
Tinverbindingen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke tinverbinding voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. Download PDFInfo
- Publication number
- NL8102269A NL8102269A NL8102269A NL8102269A NL8102269A NL 8102269 A NL8102269 A NL 8102269A NL 8102269 A NL8102269 A NL 8102269A NL 8102269 A NL8102269 A NL 8102269A NL 8102269 A NL8102269 A NL 8102269A
- Authority
- NL
- Netherlands
- Prior art keywords
- formula
- tin compound
- sheet
- process according
- formula sheet
- Prior art date
Links
- 150000003606 tin compounds Chemical class 0.000 title claims description 51
- 238000000034 method Methods 0.000 title claims description 45
- 206010028980 Neoplasm Diseases 0.000 title claims description 8
- 201000011510 cancer Diseases 0.000 title claims description 8
- 229940126601 medicinal product Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 23
- 239000003814 drug Substances 0.000 claims description 8
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical group [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 6
- 239000003446 ligand Substances 0.000 claims description 5
- 125000000962 organic group Chemical group 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 125000004429 atom Chemical group 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 125000005843 halogen group Chemical group 0.000 claims description 3
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical compound N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 claims description 2
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims description 2
- 125000000129 anionic group Chemical group 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 125000005842 heteroatom Chemical group 0.000 claims description 2
- 125000001905 inorganic group Chemical group 0.000 claims description 2
- 229910009053 Sn—O—Sn Inorganic materials 0.000 claims 2
- 239000003973 paint Substances 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 35
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 27
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- 238000002844 melting Methods 0.000 description 7
- 230000008018 melting Effects 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 5
- 229910052794 bromium Inorganic materials 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 5
- 229910052718 tin Inorganic materials 0.000 description 5
- QARVLSVVCXYDNA-UHFFFAOYSA-N bromobenzene Chemical compound BrC1=CC=CC=C1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 description 4
- 239000003208 petroleum Substances 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 230000000259 anti-tumor effect Effects 0.000 description 3
- 125000003710 aryl alkyl group Chemical group 0.000 description 3
- OCRRXQDJWXOSCL-UHFFFAOYSA-L cyclohexyl(phenyl)tin(2+);dichloride Chemical compound C=1C=CC=CC=1[Sn](Cl)(Cl)C1CCCCC1 OCRRXQDJWXOSCL-UHFFFAOYSA-L 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- BOXFGLXZZLKHKA-UHFFFAOYSA-K 2,2-diphenylethyltin(3+);trihydroxide Chemical compound [OH-].[OH-].[OH-].C=1C=CC=CC=1C(C[Sn+3])C1=CC=CC=C1 BOXFGLXZZLKHKA-UHFFFAOYSA-K 0.000 description 2
- UDOPITICNQWATG-UHFFFAOYSA-N 2-[1-(4-chlorophenyl)-2,5-dioxoimidazolidin-4-yl]acetic acid Chemical compound O=C1C(CC(=O)O)NC(=O)N1C1=CC=C(Cl)C=C1 UDOPITICNQWATG-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- PBCJCAYCIIIVRA-UHFFFAOYSA-N benzyl-oxo-propyltin Chemical compound CCC[Sn](=O)CC1=CC=CC=C1 PBCJCAYCIIIVRA-UHFFFAOYSA-N 0.000 description 2
- MYYPSWTVUTUEIP-UHFFFAOYSA-N butyl-(2-chloroethyl)-oxotin Chemical compound ClCC[Sn](CCCC)=O MYYPSWTVUTUEIP-UHFFFAOYSA-N 0.000 description 2
- CUGVIQKWJHTLQN-UHFFFAOYSA-N butyl-oxo-phenyltin Chemical compound CCCC[Sn](=O)C1=CC=CC=C1 CUGVIQKWJHTLQN-UHFFFAOYSA-N 0.000 description 2
- KSKDYXPDZBGCSA-UHFFFAOYSA-M chloro-bis(2-methylphenyl)tin Chemical compound CC1=CC=CC=C1[Sn](Cl)C1=CC=CC=C1C KSKDYXPDZBGCSA-UHFFFAOYSA-M 0.000 description 2
- OPPINNAXNFZQLG-UHFFFAOYSA-M chloro-bis(4-methylphenyl)tin Chemical compound C1=CC(C)=CC=C1[Sn](Cl)C1=CC=C(C)C=C1 OPPINNAXNFZQLG-UHFFFAOYSA-M 0.000 description 2
- PKKGKUDPKRTKLJ-UHFFFAOYSA-L dichloro(dimethyl)stannane Chemical compound C[Sn](C)(Cl)Cl PKKGKUDPKRTKLJ-UHFFFAOYSA-L 0.000 description 2
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- IAJWDDOJYUXIHE-UHFFFAOYSA-N ethyl(triphenyl)stannane Chemical compound C=1C=CC=CC=1[Sn](C=1C=CC=CC=1)(CC)C1=CC=CC=C1 IAJWDDOJYUXIHE-UHFFFAOYSA-N 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 229910052732 germanium Inorganic materials 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 208000003747 lymphoid leukemia Diseases 0.000 description 2
- 231100000417 nephrotoxicity Toxicity 0.000 description 2
- CKWIFRIQLGNJJQ-UHFFFAOYSA-N oxo-phenyl-propyltin Chemical compound CCC[Sn](=O)C1=CC=CC=C1 CKWIFRIQLGNJJQ-UHFFFAOYSA-N 0.000 description 2
- -1 platinum diamine Chemical class 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- FLHJWTVEWXPCJX-UHFFFAOYSA-K 2,2-diphenylethyl(triiodo)stannane Chemical compound C=1C=CC=CC=1C(C[Sn](I)(I)I)C1=CC=CC=C1 FLHJWTVEWXPCJX-UHFFFAOYSA-K 0.000 description 1
- ARBGBCQCAFWNDH-UHFFFAOYSA-N 2-methoxy-4-(1,3-thiazolidin-2-yl)phenol Chemical compound C1=C(O)C(OC)=CC(C2SCCN2)=C1 ARBGBCQCAFWNDH-UHFFFAOYSA-N 0.000 description 1
- MUWBADGLKHMCGP-UHFFFAOYSA-N 4,4,4-triphenylbutyltin Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(CCC[Sn])C1=CC=CC=C1 MUWBADGLKHMCGP-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 239000002253 acid Chemical group 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229940045985 antineoplastic platinum compound Drugs 0.000 description 1
- YCOXTKKNXUZSKD-UHFFFAOYSA-N as-o-xylenol Natural products CC1=CC=C(O)C=C1C YCOXTKKNXUZSKD-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- BALALLQYJLRYRJ-UHFFFAOYSA-N benzyl(3,3-diphenylpropyl)tin Chemical compound C=1C=CC=CC=1C[Sn]CCC(C=1C=CC=CC=1)C1=CC=CC=C1 BALALLQYJLRYRJ-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- MKZIXXFZWGUNJM-UHFFFAOYSA-L bis(4-methylphenyl)tin(2+);dichloride Chemical compound C1=CC(C)=CC=C1[Sn](Cl)(Cl)C1=CC=C(C)C=C1 MKZIXXFZWGUNJM-UHFFFAOYSA-L 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- MHLRQNUHYLJURU-UHFFFAOYSA-N butan-2-yl(triphenyl)stannane Chemical compound C=1C=CC=CC=1[Sn](C=1C=CC=CC=1)(C(C)CC)C1=CC=CC=C1 MHLRQNUHYLJURU-UHFFFAOYSA-N 0.000 description 1
- IDWRSWYHVHCJKX-UHFFFAOYSA-N butan-2-yl-oxo-phenyltin Chemical compound CCC(C)[Sn](=O)C1=CC=CC=C1 IDWRSWYHVHCJKX-UHFFFAOYSA-N 0.000 description 1
- 125000005587 carbonate group Chemical group 0.000 description 1
- 150000007942 carboxylates Chemical group 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- IYVLCOCDQBXIGK-UHFFFAOYSA-M chloro-cyclohexyl-phenyltin Chemical compound C=1C=CC=CC=1[Sn](Cl)C1CCCCC1 IYVLCOCDQBXIGK-UHFFFAOYSA-M 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- JLAOLGQVKOWVNT-UHFFFAOYSA-N cyclohexyl(triphenyl)stannane Chemical compound C1CCCCC1[Sn](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 JLAOLGQVKOWVNT-UHFFFAOYSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- RJGHQTVXGKYATR-UHFFFAOYSA-L dibutyl(dichloro)stannane Chemical compound CCCC[Sn](Cl)(Cl)CCCC RJGHQTVXGKYATR-UHFFFAOYSA-L 0.000 description 1
- MGAUKEZPAMVFNT-UHFFFAOYSA-L dichloro-bis(2-methylphenyl)stannane Chemical compound CC1=CC=CC=C1[Sn](Cl)(Cl)C1=CC=CC=C1C MGAUKEZPAMVFNT-UHFFFAOYSA-L 0.000 description 1
- BXVLQFGQYHYURU-UHFFFAOYSA-N diethyltin Chemical compound CC[Sn]CC BXVLQFGQYHYURU-UHFFFAOYSA-N 0.000 description 1
- PWEVMPIIOJUPRI-UHFFFAOYSA-N dimethyltin Chemical compound C[Sn]C PWEVMPIIOJUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- MPXPGCBVGMIVLD-UHFFFAOYSA-N ethyl-oxo-phenyltin Chemical compound CC[Sn](=O)C1=CC=CC=C1 MPXPGCBVGMIVLD-UHFFFAOYSA-N 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- SNHMUERNLJLMHN-UHFFFAOYSA-N iodobenzene Chemical compound IC1=CC=CC=C1 SNHMUERNLJLMHN-UHFFFAOYSA-N 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N nitrate group Chemical group [N+](=O)([O-])[O-] NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 229910017464 nitrogen compound Inorganic materials 0.000 description 1
- 150000002830 nitrogen compounds Chemical class 0.000 description 1
- 231100001095 no nephrotoxicity Toxicity 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 150000002902 organometallic compounds Chemical class 0.000 description 1
- 229910052760 oxygen Chemical group 0.000 description 1
- 239000001301 oxygen Chemical group 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- 150000003058 platinum compounds Chemical class 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000004001 thioalkyl group Chemical group 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- ITKMFPITMVNDNL-UHFFFAOYSA-N triphenyl(propyl)stannane Chemical compound C=1C=CC=CC=1[Sn](C=1C=CC=CC=1)(CCC)C1=CC=CC=C1 ITKMFPITMVNDNL-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2224—Compounds having one or more tin-oxygen linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR65105A GR78341B (es) | 1980-05-30 | 1981-02-16 | |
| NL8102269A NL8102269A (nl) | 1980-05-30 | 1981-05-08 | Tinverbindingen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke tinverbinding voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. |
| FR8110746A FR2483424B1 (fr) | 1980-05-30 | 1981-05-29 | Composes d'etain utiles comme medicament, medicament obtenu et procede de preparation dudit medicament |
| SE8103404A SE8103404L (sv) | 1980-05-30 | 1981-05-29 | Tennforeningar, sett att framstella dem, sett att framstella ett lekemedelspreparat under anvendning av en dylik tennforening for behandling av cancer samt det pa sa sett erhallna lekemedelspreparatet |
| DK236681A DK236681A (da) | 1980-05-30 | 1981-05-29 | Fremgangsmaade til fremstilling af tinforbindelser |
| AR285502A AR225517A1 (es) | 1980-05-30 | 1981-05-29 | Metodo de preparacion del nuevo compuesto oxido de bis-(cloroetilbutilestano) |
| IT8122036A IT8122036A0 (it) | 1980-05-30 | 1981-05-29 | Composti di stagno, procedimento per la loro preparazione, procedimento per la preparazione di un farmaco per il trattamento del cancro mediante un tale composto di stagno, nonche' medicinale finito cosi' ottenuto. |
| LU83398A LU83398A1 (fr) | 1980-05-30 | 1981-05-29 | Composes d'etain utiles comme medicament,medicament obtenu et procede de preparation dudit medicament |
| ES502621A ES8300780A1 (es) | 1980-05-30 | 1981-05-29 | Procedimiento para preparar oxido de bis(cloroetil-butilestano) |
| NO811813A NO811813L (no) | 1980-05-30 | 1981-05-29 | Fremgangsmaate ved fremstilling av tinnforbindelser for behandling av kreft. |
| NZ197240A NZ197240A (en) | 1980-05-30 | 1981-05-29 | Organo-tin compounds and anti-tumour compositions |
| YU01375/81A YU137581A (en) | 1980-05-30 | 1981-05-29 | Process for obtaining tin compounds |
| KR1019810001895A KR830005861A (ko) | 1981-05-08 | 1981-05-29 | 주석 화합물 및 주석 화합물을 이용한 암 치료용 의약 제조방법 |
| PT73102A PT73102B (en) | 1980-05-30 | 1981-05-29 | Process for preparing tin compounds |
| IL62987A IL62987A0 (en) | 1980-05-30 | 1981-05-29 | Tin compounds,a process for the preparation thereof,a process for the preparation of a medicine using such a tin compound for the treatment of cancer,as well as the shaped medicine thus formed and obtained |
| GB8116521A GB2077266A (en) | 1980-05-30 | 1981-05-29 | Tin compounds for the treatment of cancer |
| AU71151/81A AU7115181A (en) | 1980-05-30 | 1981-05-29 | Tin compounds |
| DE19813121551 DE3121551A1 (de) | 1980-05-30 | 1981-05-29 | Zinnverbindungen, verfahren zu deren herstellung und dieselben enthaltende arzneimittel zur krebsbehandlung |
| FI811662A FI811662L (fi) | 1980-05-30 | 1981-05-29 | Tennfoereningar foerfarande foer framstaellning av dem foerfarande foer framstaellning av cancerlaekemedel ur dessa tennfoereningar samt saolunda erhaollna laekemedel |
| DD81230468A DD159641A5 (de) | 1980-05-30 | 1981-06-01 | Verfahren zur herstellung eines medikaments zur krebsbehandlung |
| DD81247594A DD208357A5 (de) | 1980-05-30 | 1981-06-01 | Verfahren zur herstellung einer organischen zinnverbindung |
| AR288670A AR226504A1 (es) | 1980-05-30 | 1982-03-08 | Metodo de preparacion de los nuevos compuestos oxido de bis(disubstituido con radical organico-cloroestano) |
| ES512754A ES8304581A1 (es) | 1980-05-30 | 1982-06-01 | Procedimiento para preparar compuestos de estano. |
| ES512755A ES8304582A1 (es) | 1980-05-30 | 1982-06-01 | Procedimiento para preparar compuestos de estano. |
| US06/417,091 US4547320A (en) | 1980-05-30 | 1982-09-13 | Tin compounds |
| YU01351/83A YU135183A (en) | 1980-05-30 | 1983-06-20 | Process for obtaining tin compounds |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8003160 | 1980-05-30 | ||
| NL8003160 | 1980-05-30 | ||
| NL8102269 | 1981-05-08 | ||
| NL8102269A NL8102269A (nl) | 1980-05-30 | 1981-05-08 | Tinverbindingen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke tinverbinding voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8102269A true NL8102269A (nl) | 1981-12-16 |
Family
ID=26645628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8102269A NL8102269A (nl) | 1980-05-30 | 1981-05-08 | Tinverbindingen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke tinverbinding voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4547320A (es) |
| AR (2) | AR225517A1 (es) |
| AU (1) | AU7115181A (es) |
| DD (2) | DD159641A5 (es) |
| DE (1) | DE3121551A1 (es) |
| DK (1) | DK236681A (es) |
| ES (3) | ES8300780A1 (es) |
| FI (1) | FI811662L (es) |
| FR (1) | FR2483424B1 (es) |
| GB (1) | GB2077266A (es) |
| GR (1) | GR78341B (es) |
| IL (1) | IL62987A0 (es) |
| IT (1) | IT8122036A0 (es) |
| LU (1) | LU83398A1 (es) |
| NL (1) | NL8102269A (es) |
| NO (1) | NO811813L (es) |
| NZ (1) | NZ197240A (es) |
| PT (1) | PT73102B (es) |
| SE (1) | SE8103404L (es) |
| YU (2) | YU137581A (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0484596A1 (en) * | 1990-11-06 | 1992-05-13 | Pharmachemie B.V. | Organotin compounds and anti-tumor compositions containing them |
| CN102424693B (zh) * | 2011-10-10 | 2014-02-12 | 聊城大学 | 四-2,6-吡啶二羧酸-二-（二茂铁双甲酸）三苯基锡配合物及其制备方法与应用 |
| CN102391314B (zh) * | 2011-11-29 | 2013-09-11 | 聊城大学 | 2,6-吡啶二羧酸-（二茂铁单甲酸）三苯基锡配合物及其制备方法与应用 |
| WO2015046167A1 (ja) | 2013-09-26 | 2015-04-02 | 旭化成ケミカルズ株式会社 | アルキルスズ化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2597920A (en) * | 1951-06-29 | 1952-05-27 | Goodrich Co B F | Organo-tin compounds and composition including same and method of making same |
| FR1298303A (fr) * | 1956-09-18 | 1962-07-13 | Metal & Thermit Corp | Nouveau composé vinyl-stannique et procédé de préparation de ce composé |
| US2867642A (en) * | 1956-09-18 | 1959-01-06 | Metal & Thermit Corp | Divinyltin oxide and method of preparation |
| US3226292A (en) * | 1962-04-18 | 1965-12-28 | Dow Chemical Co | Bis(tripropyltin) oxide anthelmintic composition and method of using same |
-
1981
- 1981-02-16 GR GR65105A patent/GR78341B/el unknown
- 1981-05-08 NL NL8102269A patent/NL8102269A/nl not_active Application Discontinuation
- 1981-05-29 NZ NZ197240A patent/NZ197240A/en unknown
- 1981-05-29 DE DE19813121551 patent/DE3121551A1/de not_active Withdrawn
- 1981-05-29 GB GB8116521A patent/GB2077266A/en not_active Withdrawn
- 1981-05-29 YU YU01375/81A patent/YU137581A/xx unknown
- 1981-05-29 PT PT73102A patent/PT73102B/pt unknown
- 1981-05-29 ES ES502621A patent/ES8300780A1/es not_active Expired
- 1981-05-29 IT IT8122036A patent/IT8122036A0/it unknown
- 1981-05-29 LU LU83398A patent/LU83398A1/fr unknown
- 1981-05-29 AR AR285502A patent/AR225517A1/es active
- 1981-05-29 NO NO811813A patent/NO811813L/no unknown
- 1981-05-29 SE SE8103404A patent/SE8103404L/ not_active Application Discontinuation
- 1981-05-29 AU AU71151/81A patent/AU7115181A/en not_active Abandoned
- 1981-05-29 IL IL62987A patent/IL62987A0/xx unknown
- 1981-05-29 FR FR8110746A patent/FR2483424B1/fr not_active Expired
- 1981-05-29 FI FI811662A patent/FI811662L/fi not_active Application Discontinuation
- 1981-05-29 DK DK236681A patent/DK236681A/da not_active Application Discontinuation
- 1981-06-01 DD DD81230468A patent/DD159641A5/de unknown
- 1981-06-01 DD DD81247594A patent/DD208357A5/de unknown
-
1982
- 1982-03-08 AR AR288670A patent/AR226504A1/es active
- 1982-06-01 ES ES512755A patent/ES8304582A1/es not_active Expired
- 1982-06-01 ES ES512754A patent/ES8304581A1/es not_active Expired
- 1982-09-13 US US06/417,091 patent/US4547320A/en not_active Expired - Fee Related
-
1983
- 1983-06-20 YU YU01351/83A patent/YU135183A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO811813L (no) | 1981-12-01 |
| AU7115181A (en) | 1981-12-03 |
| IL62987A0 (en) | 1981-07-31 |
| ES512754A0 (es) | 1983-03-01 |
| ES512755A0 (es) | 1983-03-01 |
| DD159641A5 (de) | 1983-03-23 |
| AR225517A1 (es) | 1982-03-31 |
| ES502621A0 (es) | 1982-11-01 |
| DD208357A5 (de) | 1984-05-02 |
| LU83398A1 (fr) | 1981-09-11 |
| ES8304582A1 (es) | 1983-03-01 |
| FI811662L (fi) | 1981-12-01 |
| YU135183A (en) | 1983-12-31 |
| SE8103404L (sv) | 1981-12-01 |
| GB2077266A (en) | 1981-12-16 |
| IT8122036A0 (it) | 1981-05-29 |
| PT73102B (en) | 1985-01-08 |
| NZ197240A (en) | 1984-07-06 |
| ES8304581A1 (es) | 1983-03-01 |
| ES8300780A1 (es) | 1982-11-01 |
| AR226504A1 (es) | 1982-07-15 |
| FR2483424B1 (fr) | 1985-10-25 |
| PT73102A (en) | 1981-06-01 |
| US4547320A (en) | 1985-10-15 |
| GR78341B (es) | 1984-09-26 |
| DK236681A (da) | 1981-12-01 |
| FR2483424A1 (fr) | 1981-12-04 |
| YU137581A (en) | 1983-12-31 |
| DE3121551A1 (de) | 1982-04-22 |
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| BT | A notification was added to the application dossier and made available to the public | ||
| A85 | Still pending on 85-01-01 | ||
| BV | The patent application has lapsed |