NL8101749A - Cholesterolbiosyntheseremmende verbindingen en hun bereiding. - Google Patents
Cholesterolbiosyntheseremmende verbindingen en hun bereiding. Download PDFInfo
- Publication number
- NL8101749A NL8101749A NL8101749A NL8101749A NL8101749A NL 8101749 A NL8101749 A NL 8101749A NL 8101749 A NL8101749 A NL 8101749A NL 8101749 A NL8101749 A NL 8101749A NL 8101749 A NL8101749 A NL 8101749A
- Authority
- NL
- Netherlands
- Prior art keywords
- group
- carboxylate
- hydrogen atom
- formula
- sodium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/80—Penicillium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/80—Penicillium
- C12R2001/82—Penicillium chrysogenum
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/80—Penicillium
- C12R2001/825—Penicillium notatum
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Botany (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4600480 | 1980-04-08 | ||
JP4600480A JPS56142236A (en) | 1980-04-08 | 1980-04-08 | Ml-236a and mb-530a derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
NL8101749A true NL8101749A (nl) | 1981-11-02 |
Family
ID=12734918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL8101749A NL8101749A (nl) | 1980-04-08 | 1981-04-08 | Cholesterolbiosyntheseremmende verbindingen en hun bereiding. |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS56142236A (da) |
BE (1) | BE888332A (da) |
DE (1) | DE3114242A1 (da) |
DK (1) | DK158781A (da) |
FI (1) | FI811080L (da) |
FR (1) | FR2479809A1 (da) |
GB (1) | GB2073199A (da) |
IT (1) | IT1144327B (da) |
NL (1) | NL8101749A (da) |
SE (1) | SE8102254L (da) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4450171A (en) * | 1980-08-05 | 1984-05-22 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
JPS5855443A (ja) * | 1981-09-25 | 1983-04-01 | Sankyo Co Ltd | オクタヒドロナフタリン誘導体およびその製造法 |
CA1327360C (en) * | 1983-11-14 | 1994-03-01 | William F. Hoffman | Oxo-analogs of mevinolin-like antihypercholesterolemic agents |
DE3580863D1 (de) * | 1984-06-04 | 1991-01-24 | Merck & Co Inc | Herstellungsverfahren von hemmstoffen der hmg-coa-reduktase mit einer 3,5-dihydroxypentanoatteilstruktur. |
EP0204287A3 (en) * | 1985-06-04 | 1987-07-01 | Merck & Co. Inc. | Process for the preparation of hmg-coa reductase inhibitors with a 3,5-dihydroxypentanoate subunit |
US4997848A (en) | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
US5250435A (en) * | 1991-06-04 | 1993-10-05 | Merck & Co., Inc. | Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I) |
GB0003305D0 (en) | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
US7034180B2 (en) * | 2000-09-07 | 2006-04-25 | Kaneka Corporation | Method for crystallization of hydroxycarboxylic acids |
EA200400034A1 (ru) | 2001-06-13 | 2004-06-24 | Ранбакси Лабораторис Лимитед | МЕТИЛОВЫЕ АНАЛОГИ СИМВАСТАТИНА В КАЧЕСТВЕ НОВЫХ ИНГИБИТОРОВ HMG-CoA РЕДУКТАЗЫ |
US8158362B2 (en) | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5612114B2 (da) | 1974-06-07 | 1981-03-18 | ||
JPS5840475B2 (ja) * | 1975-05-12 | 1983-09-06 | 三共株式会社 | 新生理活性物質ml−236aおよびその製造法 |
JPS5817443B2 (ja) * | 1976-11-02 | 1983-04-07 | 三共株式会社 | Ml−236b金属塩を主成分とする高脂血症治療剤 |
JPS5925599B2 (ja) | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンkおよびその製造法 |
JPS55150898A (en) | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
-
1980
- 1980-04-08 JP JP4600480A patent/JPS56142236A/ja active Pending
-
1981
- 1981-04-08 NL NL8101749A patent/NL8101749A/nl not_active Application Discontinuation
- 1981-04-08 IT IT67490/81A patent/IT1144327B/it active
- 1981-04-08 DK DK158781A patent/DK158781A/da not_active IP Right Cessation
- 1981-04-08 DE DE3114242A patent/DE3114242A1/de not_active Withdrawn
- 1981-04-08 SE SE8102254A patent/SE8102254L/xx not_active Application Discontinuation
- 1981-04-08 FI FI811080A patent/FI811080L/fi not_active Application Discontinuation
- 1981-04-08 GB GB8111061A patent/GB2073199A/en not_active Withdrawn
- 1981-04-08 FR FR8107028A patent/FR2479809A1/fr active Pending
- 1981-04-08 BE BE0/204416A patent/BE888332A/fr not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IT8167490A0 (it) | 1981-04-08 |
SE8102254L (sv) | 1981-10-09 |
BE888332A (fr) | 1981-10-08 |
FR2479809A1 (fr) | 1981-10-09 |
IT1144327B (it) | 1986-10-29 |
FI811080L (fi) | 1981-10-09 |
GB2073199A (en) | 1981-10-14 |
DK158781A (da) | 1981-10-09 |
DE3114242A1 (de) | 1982-06-16 |
JPS56142236A (en) | 1981-11-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2114912C1 (ru) | Способ выделения ловастатина | |
US4319039A (en) | Preparation of ammonium salt of hypocholesteremic fermentation product | |
US4342767A (en) | Hypocholesteremic fermentation products | |
US4361515A (en) | Antihyperlipemic dihydro-ML-236B derivatives, their preparation and use | |
KR830002438B1 (ko) | 저 콜레스테린 혈증성 발효 생성물의 제법 | |
CA1161380A (en) | Hypocholesteremic fermentation products and process of preparation | |
WO1994029292A9 (en) | Process for the isolation of lovastatin | |
HRP20020683A2 (en) | Method of purifying a fermentation broth | |
NL8101749A (nl) | Cholesterolbiosyntheseremmende verbindingen en hun bereiding. | |
FI71300B (fi) | Foerfarande foer framstaellning av salter och estrar av syran som svarar mot monakolin-k vilka har antihyperkolesteremisk effekt | |
US6268186B1 (en) | HMG-CoA reductase inhibitor preparation process | |
DE3112566A1 (de) | Monacolin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel | |
JP3236282B1 (ja) | プラバスタチンを精製する方法 | |
JPH0115491B2 (da) | ||
US5347039A (en) | Process for the preparation of derivatives of 3,5-dihydroxypentanoic acid | |
FR2518546A1 (fr) | Dihydro- et tetrahydromonacolines l, leur procede de preparation et leur application en therapeutique | |
ZA200302968B (en) | Method of purifying pravastatin or its pharmacologically acceptable salt. | |
EP0068680B1 (en) | Antibiotics | |
FR2557455A1 (fr) | Antibiotique nouveau 81-484 antitumeur et sa production | |
EP1487814B1 (en) | Process for the preparation of 4-oxytetrahydropyran-2-ones | |
EP0260486B1 (de) | Neue pharmakologisch wirksame Phenoxazinone, Verfahren zu ihrer Herstellung und ihre Verwendung | |
JPH0538295A (ja) | ウロポルフイリンiii の製造方法 | |
BE556763A (da) | ||
CS221919B2 (cs) | Způsob přípravy směsi hypocholesterolemický sloučenin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
BV | The patent application has lapsed |