NL8002177A - Nogamycine, nogamycine-analoga, werkwijze voor het bereiden daarvan en farmaceutische preparaten op basis daarvan. - Google Patents
Nogamycine, nogamycine-analoga, werkwijze voor het bereiden daarvan en farmaceutische preparaten op basis daarvan. Download PDFInfo
- Publication number
- NL8002177A NL8002177A NL8002177A NL8002177A NL8002177A NL 8002177 A NL8002177 A NL 8002177A NL 8002177 A NL8002177 A NL 8002177A NL 8002177 A NL8002177 A NL 8002177A NL 8002177 A NL8002177 A NL 8002177A
- Authority
- NL
- Netherlands
- Prior art keywords
- compound
- con
- deoxynogarol
- acid
- pharmaceutically acceptable
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 20
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 4
- NNEGMXMRXKXKMQ-ZEOBNFASSA-N disnogamycin Chemical compound CO[C@@H]1[C@@](OC)(C)[C@@H](OC)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=C(O)C=C4[C@@]5(C)O[C@H]([C@H]([C@@H]([C@H]5O)N(C)C)O)OC4=C3C3=O)=C3C=C2C[C@@](C)(O)C1 NNEGMXMRXKXKMQ-ZEOBNFASSA-N 0.000 title description 27
- 150000001875 compounds Chemical class 0.000 claims description 58
- 239000002253 acid Substances 0.000 claims description 55
- 239000000203 mixture Substances 0.000 claims description 44
- -1 sulfide anion Chemical class 0.000 claims description 35
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 30
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 20
- 239000004480 active ingredient Substances 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 125000003545 alkoxy group Chemical group 0.000 claims description 7
- 230000000269 nucleophilic effect Effects 0.000 claims description 7
- 239000012434 nucleophilic reagent Substances 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 125000004122 cyclic group Chemical group 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
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- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3261479A | 1979-04-23 | 1979-04-23 | |
| US3261479 | 1979-04-23 | ||
| US6032679A | 1979-07-25 | 1979-07-25 | |
| US6032679 | 1979-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8002177A true NL8002177A (nl) | 1980-10-27 |
Family
ID=26708664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8002177A NL8002177A (nl) | 1979-04-23 | 1980-04-15 | Nogamycine, nogamycine-analoga, werkwijze voor het bereiden daarvan en farmaceutische preparaten op basis daarvan. |
Country Status (5)
| Country | Link |
|---|---|
| CH (1) | CH649558A5 (Direct) |
| DE (1) | DE3014994A1 (Direct) |
| FR (1) | FR2455049A1 (Direct) |
| GB (1) | GB2049689B (Direct) |
| NL (1) | NL8002177A (Direct) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4318790A (en) * | 1980-03-17 | 1982-03-09 | The Upjohn Company | Photochemical process for preparing N-demethyl-derivatives of nogalamycin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4086245A (en) * | 1976-12-09 | 1978-04-25 | The Upjohn Company | Antibiotics 7-O-alkylnogarols |
-
1980
- 1980-04-11 GB GB8012034A patent/GB2049689B/en not_active Expired
- 1980-04-15 NL NL8002177A patent/NL8002177A/nl not_active Application Discontinuation
- 1980-04-16 CH CH294780A patent/CH649558A5/de not_active IP Right Cessation
- 1980-04-18 DE DE19803014994 patent/DE3014994A1/de not_active Withdrawn
- 1980-04-22 FR FR8008989A patent/FR2455049A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2455049B1 (Direct) | 1983-07-29 |
| CH649558A5 (de) | 1985-05-31 |
| DE3014994A1 (de) | 1980-11-06 |
| FR2455049A1 (fr) | 1980-11-21 |
| GB2049689B (en) | 1983-05-18 |
| GB2049689A (en) | 1980-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BV | The patent application has lapsed |