NL8001602A - Nitrosoureumderivaten met anti-tumorwerkzaamheid, als- mede daarmee samengestelde farmaceutische samenstel- ling. - Google Patents
Nitrosoureumderivaten met anti-tumorwerkzaamheid, als- mede daarmee samengestelde farmaceutische samenstel- ling. Download PDFInfo
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- NL8001602A NL8001602A NL8001602A NL8001602A NL8001602A NL 8001602 A NL8001602 A NL 8001602A NL 8001602 A NL8001602 A NL 8001602A NL 8001602 A NL8001602 A NL 8001602A NL 8001602 A NL8001602 A NL 8001602A
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- mouse
- ppm
- chloroethyl
- nitrosourea
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- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/66—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to halogen atoms or to nitro or nitroso groups
- C07C275/68—N-nitroso ureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/064,886 US4423076A (en) | 1979-08-08 | 1979-08-08 | 1-Branched-alkyl-3-(2-haloethyl)-3-nitrosoureas as novel antitumor agents |
| US6488679 | 1979-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8001602A true NL8001602A (nl) | 1981-02-10 |
Family
ID=22058871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8001602A NL8001602A (nl) | 1979-08-08 | 1980-03-18 | Nitrosoureumderivaten met anti-tumorwerkzaamheid, als- mede daarmee samengestelde farmaceutische samenstel- ling. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4423076A (de) |
| JP (1) | JPS5653647A (de) |
| AU (1) | AU532391B2 (de) |
| CA (1) | CA1179372A (de) |
| CH (1) | CH643237A5 (de) |
| DE (1) | DE3020498A1 (de) |
| DK (1) | DK281980A (de) |
| FR (1) | FR2465716A1 (de) |
| GB (1) | GB2056450B (de) |
| HU (1) | HU182184B (de) |
| IT (1) | IT1149819B (de) |
| NL (1) | NL8001602A (de) |
| NO (1) | NO151545C (de) |
| SE (1) | SE8005574L (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5994668U (ja) * | 1982-12-17 | 1984-06-27 | 三井造船株式会社 | 緊急遮断装置 |
| GB9719426D0 (en) * | 1997-09-13 | 1997-11-12 | Johnson Matthey Plc | Novel process |
| FR2768516B1 (fr) * | 1997-09-16 | 1999-10-29 | Inst Bouisson Bertrand | Utilisation d'isocyanates pour le dosage de fonctions nucleophiles a l'etat de traces en milieu humide |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4180655A (en) * | 1974-08-08 | 1979-12-25 | Tetsuo Suami | Nitrosourea derivatives |
| US4039578A (en) * | 1976-03-08 | 1977-08-02 | Suami T | 1-Tetrahydroxycyclopentyl-3-nitroso-3-(2-chloroethyl)-urea antitumor agents |
| US4148921A (en) * | 1977-07-13 | 1979-04-10 | Suami T | Antitumor agents |
-
1979
- 1979-08-08 US US06/064,886 patent/US4423076A/en not_active Expired - Lifetime
-
1980
- 1980-03-05 CA CA000347028A patent/CA1179372A/en not_active Expired
- 1980-03-18 NL NL8001602A patent/NL8001602A/nl not_active Application Discontinuation
- 1980-04-01 AU AU57038/80A patent/AU532391B2/en not_active Ceased
- 1980-04-21 JP JP5279780A patent/JPS5653647A/ja active Pending
- 1980-04-28 FR FR8009493A patent/FR2465716A1/fr active Granted
- 1980-05-30 DE DE19803020498 patent/DE3020498A1/de not_active Withdrawn
- 1980-06-13 CH CH455580A patent/CH643237A5/de not_active IP Right Cessation
- 1980-06-30 DK DK281980A patent/DK281980A/da not_active Application Discontinuation
- 1980-08-05 NO NO802348A patent/NO151545C/no unknown
- 1980-08-06 SE SE8005574A patent/SE8005574L/xx not_active Application Discontinuation
- 1980-08-07 HU HU801963A patent/HU182184B/hu unknown
- 1980-08-07 GB GB8025813A patent/GB2056450B/en not_active Expired
- 1980-08-07 IT IT24040/80A patent/IT1149819B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| IT1149819B (it) | 1986-12-10 |
| JPS5653647A (en) | 1981-05-13 |
| NO802348L (no) | 1981-02-09 |
| US4423076A (en) | 1983-12-27 |
| NO151545B (no) | 1985-01-14 |
| GB2056450B (en) | 1983-04-07 |
| HU182184B (en) | 1983-12-28 |
| GB2056450A (en) | 1981-03-18 |
| CH643237A5 (de) | 1984-05-30 |
| AU5703880A (en) | 1981-02-12 |
| DK281980A (da) | 1981-02-09 |
| FR2465716B1 (de) | 1983-07-08 |
| IT8024040A0 (it) | 1980-08-07 |
| NO151545C (no) | 1985-05-02 |
| AU532391B2 (en) | 1983-09-29 |
| FR2465716A1 (fr) | 1981-03-27 |
| CA1179372A (en) | 1984-12-11 |
| SE8005574L (sv) | 1981-02-09 |
| DE3020498A1 (de) | 1981-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| A85 | Still pending on 85-01-01 | ||
| BV | The patent application has lapsed |