NL7613276A - Nieuwe pyrazinecarboxamiden en werkwijzen ter bereiding ervan. - Google Patents

Nieuwe pyrazinecarboxamiden en werkwijzen ter bereiding ervan.

Info

Publication number
NL7613276A
NL7613276A NL7613276A NL7613276A NL7613276A NL 7613276 A NL7613276 A NL 7613276A NL 7613276 A NL7613276 A NL 7613276A NL 7613276 A NL7613276 A NL 7613276A NL 7613276 A NL7613276 A NL 7613276A
Authority
NL
Netherlands
Prior art keywords
preparing
methods
carboxamides
new pyrazine
new
Prior art date
Application number
NL7613276A
Other languages
English (en)
Dutch (nl)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NL7613276A publication Critical patent/NL7613276A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NL7613276A 1975-12-15 1976-11-29 Nieuwe pyrazinecarboxamiden en werkwijzen ter bereiding ervan. NL7613276A (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64080375A 1975-12-15 1975-12-15

Publications (1)

Publication Number Publication Date
NL7613276A true NL7613276A (nl) 1977-06-17

Family

ID=24569755

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7613276A NL7613276A (nl) 1975-12-15 1976-11-29 Nieuwe pyrazinecarboxamiden en werkwijzen ter bereiding ervan.

Country Status (14)

Country Link
US (1) US4085211A (fr)
JP (1) JPS52106877A (fr)
AU (1) AU511429B2 (fr)
BE (1) BE849379A (fr)
CH (1) CH630369A5 (fr)
DE (1) DE2656374A1 (fr)
DK (1) DK531476A (fr)
ES (2) ES454160A1 (fr)
FR (1) FR2335226A1 (fr)
GB (1) GB1527297A (fr)
HU (1) HU175504B (fr)
NL (1) NL7613276A (fr)
SE (1) SE431452B (fr)
ZA (1) ZA767431B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208413A (en) * 1977-03-04 1980-06-17 Merck & Co., Inc. N-Pyrazinecarbonyl-N'-alkoxycarbonyl and N',N"-bis(alkoxycarbonyl)guanidines and processes for preparing same
US4163781A (en) * 1978-04-17 1979-08-07 Merck & Co., Inc. 3-Amino-N-[(phosphonoamino)iminomethyl]-6-halopyrazinecarboxamide compounds, compositions and methods of use
EP0009054A1 (fr) * 1978-09-19 1980-04-02 Merck & Co. Inc. N-Pyrazinecarbonyl-sulfamoylguanidines substituées en N' et procédés pour leur préparation
US4277602A (en) * 1980-07-02 1981-07-07 Merck & Co., Inc. 3-Amino-5-substituted-6-halo-N-(3,4-dihydro-6-substituted-1,3,5-truazin-2-yl)2-pyrazinecarboxamides
US4272537A (en) * 1980-07-02 1981-06-09 Merck & Co., Inc. 3-Amino-5-substituted-6-halo-N-(4,4-disubstituted-6-substituted-1,3,5-triazin-2-yl)-2-pyrazinecarboxamides
FI820266L (fi) * 1981-02-02 1982-08-03 Ici Plc Alkanolaminderivater
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
JPS62291361A (ja) * 1986-06-09 1987-12-18 株式会社ブリヂストン 床支持装置
JPS6342741U (fr) * 1986-09-04 1988-03-22
GB8810933D0 (en) * 1987-05-26 1988-06-15 Ici America Inc Heterocyclic compounds
GB8810934D0 (en) * 1987-05-26 1988-06-15 Ici America Inc Amides
GB8812343D0 (en) * 1988-05-25 1988-06-29 Ici America Inc Amino compounds
GB8812342D0 (en) * 1988-05-25 1988-06-29 Ici America Inc Bicyclic compounds
JPH02101937U (fr) * 1989-01-31 1990-08-14
AUPP646498A0 (en) * 1998-10-12 1998-11-05 Australian National University, The A method of modulating ion channel functional activity
US6858615B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
WO2006023617A2 (fr) * 2004-08-18 2006-03-02 Johnson Michael R Bloqueurs des canaux sodiques a base d'amide cyclique et d'ester pyrazinoylguanidine
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
GB0526244D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
KR101578235B1 (ko) 2007-12-10 2015-12-16 노파르티스 아게 유기 화합물
DE102008053024B4 (de) 2008-10-24 2015-04-30 RUHR-UNIVERSITäT BOCHUM Verwendung von Amilorid-Derivaten zur Bekämpfung von Insekten und Milben
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
PT2931713T (pt) 2012-12-17 2017-02-22 Parion Sciences Inc Derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por insuficiente hidratação das mucosas
BR112015014178A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
CN107003568B (zh) * 2014-09-18 2020-09-15 日产化学工业株式会社 液晶取向剂、液晶取向膜和液晶表示元件

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639386A (fr) * 1962-10-30
NL299929A (fr) * 1962-10-30

Also Published As

Publication number Publication date
BE849379A (fr) 1977-06-14
ES465742A1 (es) 1978-10-01
DE2656374C2 (fr) 1989-08-10
FR2335226B1 (fr) 1979-03-09
AU2018176A (en) 1978-06-08
SE7613289L (sv) 1977-06-16
AU511429B2 (en) 1980-08-21
SE431452B (sv) 1984-02-06
GB1527297A (en) 1978-10-04
HU175504B (hu) 1980-08-28
ZA767431B (en) 1978-07-26
DE2656374A1 (de) 1977-06-16
FR2335226A1 (fr) 1977-07-15
JPS6238350B2 (fr) 1987-08-17
CH630369A5 (de) 1982-06-15
JPS52106877A (en) 1977-09-07
ES454160A1 (es) 1978-03-01
US4085211A (en) 1978-04-18
DK531476A (da) 1977-06-16

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Legal Events

Date Code Title Description
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
A85 Still pending on 85-01-01
BV The patent application has lapsed