|
DE2856393C2
(de)
*
|
1978-12-27 |
1983-04-28 |
Merz + Co GmbH & Co, 6000 Frankfurt |
Arzneimittel zur Behandlung von Morbus Parkinson
|
|
US5506231A
(en)
*
|
1989-03-31 |
1996-04-09 |
The Children's Medical Center Corporation |
Treatment of aids dementia, myelopathy and blindness
|
|
US5334618A
(en)
*
|
1991-04-04 |
1994-08-02 |
The Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
|
WO1992017168A1
(en)
*
|
1991-04-04 |
1992-10-15 |
The Children's Medical Center Corporation |
Method of preventing nmda receptor-mediated neuronal damage
|
|
US5614560A
(en)
*
|
1991-04-04 |
1997-03-25 |
Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
|
US5455279A
(en)
*
|
1991-04-19 |
1995-10-03 |
The Children's Medical Center Corporation |
Regimen method of mediating neuronal damage using nitroglycerine
|
|
DE4225730C2
(de)
*
|
1992-08-04 |
2003-04-30 |
Merz Pharma Gmbh & Co Kgaa |
Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung
|
|
US6057373A
(en)
*
|
1997-05-22 |
2000-05-02 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists
|
|
US5866585A
(en)
*
|
1997-05-22 |
1999-02-02 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia using NMDA receptor antagonists
|
|
US6294583B1
(en)
|
1998-01-13 |
2001-09-25 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders
|
|
US5952389A
(en)
*
|
1998-01-13 |
1999-09-14 |
Synchroneuron |
Methods of treating tardive dyskinesia and other movement disorders
|
|
US6444702B1
(en)
|
2000-02-22 |
2002-09-03 |
Neuromolecular, Inc. |
Aminoadamantane derivatives as therapeutic agents
|
|
EP1427404A4
(en)
*
|
2001-08-20 |
2005-10-26 |
Maiken Nedergaard |
TREATMENT OF GLIAL TUMORS WITH GLUTAMATE ANTAGONISTS
|
|
EP1298581A1
(fr)
*
|
2001-09-27 |
2003-04-02 |
C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa |
Procédé et dispositif pour calculer les valeurs des neurones d'un réseau neuronal
|
|
TW200418446A
(en)
|
2002-10-24 |
2004-10-01 |
Merz Pharma Gmbh & Co Kgaa |
Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors
|
|
AU2004251636B2
(en)
|
2003-05-27 |
2006-11-09 |
Merz Pharma Gmbh & Co. Kgaa |
Combination of an NMDA receptor antagonist and a selective serotonin reuptake inhibitor for the treatment of depression and other mood disorders
|
|
CN1240668C
(zh)
*
|
2003-09-10 |
2006-02-08 |
上海医药工业研究院 |
一种新的盐酸美金刚制备方法
|
|
US20050113458A1
(en)
*
|
2003-10-22 |
2005-05-26 |
Forest Laboratories, Inc. |
Use of 1-aminocyclohexane derivatives to modify deposition of fibrillogenic a-beta peptides in amyloidopathies
|
|
AR046314A1
(es)
|
2003-11-05 |
2005-11-30 |
Merz Pharma Gmbh & Co Kgaa |
Composiciones que comprenden ciclohexilaminas y aminoadamantanos
|
|
WO2005069742A2
(en)
*
|
2003-12-10 |
2005-08-04 |
Sun Pharmaceutical Industries Limited |
Crystal form ii of memantine hydrochloride
|
|
US20060020042A1
(en)
*
|
2004-01-05 |
2006-01-26 |
Forest Laboratories, Inc. |
Memantine for the treatment of mild and mild to moderate Alzheimer's disease
|
|
CN100363329C
(zh)
*
|
2004-01-09 |
2008-01-23 |
南京大学 |
合成美金刚胺盐酸盐的方法
|
|
US7456224B2
(en)
*
|
2004-04-05 |
2008-11-25 |
Forest Laboratories Holdings, Ltd. |
Method for treating autism
|
|
EP2397122B1
(en)
|
2004-06-17 |
2014-05-14 |
Merz Pharma GmbH & Co. KGaA |
Formulations of neramexane dosage forms
|
|
US20060002999A1
(en)
*
|
2004-06-17 |
2006-01-05 |
Forest Laboratories, Inc. |
Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
|
|
MXPA06014587A
(es)
*
|
2004-06-17 |
2007-04-27 |
Forest Laboratories |
Formulaciones de liberacion modificada de formulaciones de dosificacion oral de memantina.
|
|
TW200616608A
(en)
*
|
2004-07-09 |
2006-06-01 |
Forest Laboratories |
Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients
|
|
EP1799224A1
(en)
*
|
2004-09-23 |
2007-06-27 |
Merz Pharma GmbH & Co.KGaA |
Memantine for the treatment of childhood behavioral disorders
|
|
US20060205822A1
(en)
*
|
2004-12-22 |
2006-09-14 |
Forest Laboratories, Inc. |
1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
|
|
WO2006076560A1
(en)
*
|
2005-01-11 |
2006-07-20 |
Teva Pharmaceutical Fine Chemicals S.R.L. |
Polymorphs of memantine hydrochloride
|
|
ITMI20050833A1
(it)
*
|
2005-05-10 |
2006-11-11 |
A M S A S P A Anonima Materie Sintetiche Affini |
Nuovo procedimento per la sintesi di aminoadamantani
|
|
EP1898890A1
(en)
*
|
2005-06-16 |
2008-03-19 |
Forest Laboratories, Inc. |
Modified and immediate release memantine bead formulation
|
|
KR20170005888A
(ko)
|
2005-07-27 |
2017-01-16 |
뉴로반스, 인크. |
신규 1-아릴-3-아자바이사이클로［3.1.0］헥산：제조 방법 및 신경 정신 질환 치료를 위한 용도
|
|
US20070099947A1
(en)
*
|
2005-11-03 |
2007-05-03 |
Alkermes, Inc. |
Methods and compositions for the treatment of brain reward system disorders by combination therapy
|
|
ES2379181T3
(es)
*
|
2006-02-21 |
2012-04-23 |
Hexal Ag |
Procedimiento para la preparación de adamantanaminas
|
|
US20080033054A1
(en)
*
|
2006-03-27 |
2008-02-07 |
Valeriano Merli |
Process for preparing memantine hydrochloride substantially free of impurities
|
|
AU2007280428B2
(en)
|
2006-08-04 |
2012-04-12 |
Merz Pharma Gmbh & Co. Kgaa |
Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine
|
|
EP1908748A1
(en)
*
|
2006-10-05 |
2008-04-09 |
Krka |
Process for the preparation of memantine and its hydrochloric acid salt form
|
|
WO2008063847A2
(en)
*
|
2006-11-03 |
2008-05-29 |
Forest Laboratories Holdings Limited |
Method for treating autism
|
|
EP2124909A4
(en)
|
2006-12-19 |
2010-03-31 |
Univ Virginia |
COMBINED EFFECTS OF TOPIRAMATE AND ONDANSETRON ON ALCOHOLIC BEVERAGE
|
|
AU2008220104B2
(en)
|
2007-02-28 |
2012-09-27 |
Asahi Kasei Pharma Corporation |
Sulfonamide derivative
|
|
US9133159B2
(en)
|
2007-06-06 |
2015-09-15 |
Neurovance, Inc. |
1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
|
|
WO2008153937A2
(en)
|
2007-06-06 |
2008-12-18 |
Dov Pharmaceutical, Inc. |
Novel 1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
|
|
GB0713930D0
(en)
|
2007-07-18 |
2007-08-29 |
Generics Uk Ltd |
Novel assay methods
|
|
EP2090576A1
(en)
|
2008-02-01 |
2009-08-19 |
Merz Pharma GmbH & Co.KGaA |
6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators
|
|
EP2085398A1
(en)
|
2008-02-01 |
2009-08-05 |
Merz Pharma GmbH & Co. KGaA |
Pyrazolopyrimidines, a process for their preparation and their use as medicine
|
|
US20090247644A1
(en)
*
|
2008-03-28 |
2009-10-01 |
Forest Laboratories Holdings Limited |
Memantine formulations
|
|
WO2009128058A1
(en)
|
2008-04-18 |
2009-10-22 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al |
Psycho-pharmaceuticals
|
|
EP2111858A1
(en)
|
2008-04-25 |
2009-10-28 |
EPFL Ecole Polytechnique Fédérale de Lausanne |
Novel treatment for alzheimer's disease
|
|
US20090275597A1
(en)
*
|
2008-05-02 |
2009-11-05 |
Forest Laboratories Holdings Limited |
Methods of treating cns disorders
|
|
EP2138173A1
(en)
|
2008-06-26 |
2009-12-30 |
Merz Pharma GmbH & Co.KGaA |
Pharmaceutical compositions comprising aminoadamantane derivatives
|
|
JP5195256B2
(ja)
*
|
2008-10-10 |
2013-05-08 |
東ソー株式会社 |
アミノアダマンタン誘導体の製造方法
|
|
HRP20090186A2
(hr)
|
2009-03-31 |
2010-10-31 |
Institut Ruđer Bošković |
Adamantanski bisureidni derivati, metoda priprave i primjena u detekciji aniona
|
|
WO2010112221A1
(en)
|
2009-04-03 |
2010-10-07 |
Synthon B.V. |
Pharmaceutical compositions comprising memantine
|
|
CN102070463A
(zh)
*
|
2009-06-11 |
2011-05-25 |
辽宁利锋科技开发有限公司 |
具有金刚烷结构药物美金刚胺及其衍生物和类似物抗肿瘤新适应症的应用
|
|
TW201116532A
(en)
|
2009-08-05 |
2011-05-16 |
Merz Pharma Gmbh & Co Kgaa |
Metabotropic glutamate receptor modulators
|
|
AU2010325960C1
(en)
|
2009-12-02 |
2015-08-06 |
Adamas Pharma, Llc |
Amantadine compositions and methods of use
|
|
US20110251239A1
(en)
|
2010-04-07 |
2011-10-13 |
Eisai Inc. |
Combination therapy for the treatment of dementia
|
|
AR083475A1
(es)
|
2010-10-18 |
2013-02-27 |
Merz Pharma Gmbh & Co Kgaa |
Moduladores de receptores de glutamato metabotropicos
|
|
RU2013124827A
(ru)
|
2010-10-29 |
2014-12-10 |
Мерц Фарма Гмбх Унд Ко. Кгаа |
Производные индола и способ их получения
|
|
NO3034079T3
(sl)
|
2010-11-15 |
2018-06-09 |
|
|
|
AR084515A1
(es)
|
2010-12-22 |
2013-05-22 |
Merz Pharma Gmbh & Co Kgaa |
Derivados heterociclicos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades asociadas al sistema nervioso central tales como parkinson y alzheimer, entre otras
|
|
AR084516A1
(es)
|
2010-12-22 |
2013-05-22 |
Merz Pharma Gmbh & Co Kgaa |
Moduladores de receptores de glutamato metabotropicos
|
|
CN102241678B
(zh)
|
2011-04-26 |
2014-10-29 |
辽宁利锋科技开发有限公司 |
含有脂环结构化合物的抗肿瘤作用与应用
|
|
WO2012152854A1
(en)
|
2011-05-12 |
2012-11-15 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
|
WO2012172093A1
(en)
|
2011-06-17 |
2012-12-20 |
Merz Pharma Gmbh & Co. Kgaa |
Dihydroindolizine derivate as metabotropic glutamate receptor modulators
|
|
CN103288650B
(zh)
*
|
2012-02-28 |
2015-09-30 |
广州白云山制药股份有限公司广州白云山制药总厂 |
一种盐酸1-氨基-3,5-二甲基金刚烷的制备方法
|
|
EP2650284A1
(en)
|
2012-04-10 |
2013-10-16 |
Merz Pharma GmbH & Co. KGaA |
Heterocyclic derivatives as metabotropic glutamate receptor modulators
|
|
RU2488388C1
(ru)
|
2012-05-24 |
2013-07-27 |
Ооо "Валента Интеллект" |
Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств
|
|
US10154971B2
(en)
|
2013-06-17 |
2018-12-18 |
Adamas Pharma, Llc |
Methods of administering amantadine
|
|
US9566264B2
(en)
|
2013-07-01 |
2017-02-14 |
Euthymics Bioscience, Inc. |
Combinations and methods
|
|
NZ722077A
(en)
|
2013-12-20 |
2021-12-24 |
Agenebio Inc |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
EP3102186B1
(en)
|
2014-02-04 |
2021-01-27 |
Forest Laboratories Holdings Limited |
Donepezil compositions and method of treating alzheimer's disease
|
|
AU2016279052A1
(en)
|
2015-06-19 |
2018-02-15 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
JP6354701B2
(ja)
*
|
2015-08-19 |
2018-07-11 |
大日本印刷株式会社 |
高純度メマンチン塩酸塩の製造法
|
|
JP7174632B2
(ja)
|
2016-06-23 |
2022-11-17 |
コリウム， インコーポレイテッド |
親水性ドメインおよび疎水性ドメインならびに処置剤との接着剤マトリックス
|
|
US20180028461A1
(en)
|
2016-07-27 |
2018-02-01 |
Corium International, Inc. |
Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
|
|
EP3490541A2
(en)
|
2016-07-27 |
2019-06-05 |
Corium International, Inc. |
Transdermal formulation and delivery method of low solubility or unstable unionized neutral drugs byin situ
|
|
MX2019001104A
(es)
|
2016-07-27 |
2019-10-02 |
Corium Int Inc |
Sistemas de suministro transdermico de memantina.
|
|
US20180170941A1
(en)
|
2016-12-19 |
2018-06-21 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
US11505555B2
(en)
|
2016-12-19 |
2022-11-22 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
US10369187B2
(en)
|
2017-02-09 |
2019-08-06 |
Vanderbilt University |
Peptide regulators of JNK family kinases
|
|
JP2019094304A
(ja)
*
|
2017-11-27 |
2019-06-20 |
学校法人順天堂 |
オートファジー誘導剤
|
|
WO2019126531A1
(en)
|
2017-12-20 |
2019-06-27 |
Corium, Inc. |
Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
|
|
CN112601749B
(zh)
|
2018-06-19 |
2024-03-26 |
艾吉因生物股份有限公司 |
用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法
|
|
WO2021232232A1
(zh)
*
|
2020-05-19 |
2021-11-25 |
山东泓瑞医药科技股份公司 |
一种金刚烷胺的制备方法
|
|
WO2024039886A1
(en)
|
2022-08-19 |
2024-02-22 |
Agenebio, Inc. |
Benzazepine derivatives, compositions, and methods for treating cognitive impairment
|