NL7008881A - L-alpha-hydrazino-beta-phenylpropionic acid compounds - decarboxylase inhibitors - Google Patents

L-alpha-hydrazino-beta-phenylpropionic acid compounds - decarboxylase inhibitors

Info

Publication number
NL7008881A
NL7008881A NL7008881A NL7008881A NL7008881A NL 7008881 A NL7008881 A NL 7008881A NL 7008881 A NL7008881 A NL 7008881A NL 7008881 A NL7008881 A NL 7008881A NL 7008881 A NL7008881 A NL 7008881A
Authority
NL
Netherlands
Prior art keywords
decarboxylase
max
beta
alpha
phenylpropionic acid
Prior art date
Application number
NL7008881A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA078,423A external-priority patent/CA971974A/en
Priority claimed from CA078424A external-priority patent/CA919691A/en
Priority claimed from CA078,421,A external-priority patent/CA951662A/en
Priority claimed from CA078,419,A external-priority patent/CA951661A/en
Priority claimed from CA078,417A external-priority patent/CA956969A/en
Priority claimed from CA078420A external-priority patent/CA929483A/en
Application filed filed Critical
Publication of NL7008881A publication Critical patent/NL7008881A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D229/00—Heterocyclic compounds containing rings of less than five members having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings

Abstract

L-alpha-Hydrazine-beta-phenylpropionic acid cpds. - decarboxylase-inhibitors Cpds. of general formula (I): R1 and R2 = H, hydroxyl, alkoxy (max. C6), phenyloxy or benzyloxy; R3 and R4 = H or alkyl (max. C6); R5 = H, a metal atom or alkyl (max. C6). (I) are decarboxylase-inhibitors in mammals. They do not pass the blood-brain barrier and may be used together with L-Dopa in the treatment of Parkinsonism causing very much reduced doses of L-Dopa. They may also be used in the treatment of diseases of the large intestine, where they inhibit the formation of serotonin and contg. the occurrence of diarrhoea. (I) do not only inhibit dioxyphenylalaninedecarboxylase but also histidine-decarboxylase and may therefore be useful as histamins. (I) do not have other physiological activity. Prepd. by splitting a racemate or other mixture of the D- and L-isomers of (I) or the L-isomer of a cpd. of general formula (II) is reacted with a halogenating agent and a base, or decomposed photolytically to give (I).
NL7008881A 1969-06-18 1970-06-17 L-alpha-hydrazino-beta-phenylpropionic acid compounds - decarboxylase inhibitors NL7008881A (en)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US83530769A 1969-06-18 1969-06-18
US88637169A 1969-12-18 1969-12-18
US905270A 1970-02-05 1970-02-05
US1377070A 1970-02-24 1970-02-24
US2207670A 1970-03-23 1970-03-23
CA078,423A CA971974A (en) 1970-03-25 1970-03-25 Intermediates for preparing phenylalkanoic acids
CA078424A CA919691A (en) 1970-03-25 1970-03-25 Process for preparing substituted phenylalkanoic acids and intermediates
CA078,421,A CA951662A (en) 1970-03-25 1970-03-25 Process for preparing substituted phenylalkanoic acids
CA78418 1970-03-25
CA078,419,A CA951661A (en) 1970-03-25 1970-03-25 Process for preparing substituted phenylalkanoic acids
CA78422 1970-03-25
CA78425 1970-03-25
CA078,417A CA956969A (en) 1970-03-25 1970-03-25 Process for preparing substituted phenylalkanoic acids and intermediates
CA078420A CA929483A (en) 1970-03-25 1970-03-25 Process for preparing substituted phenylalkanoic acids

Publications (1)

Publication Number Publication Date
NL7008881A true NL7008881A (en) 1970-12-22

Family

ID=27584632

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7008881A NL7008881A (en) 1969-06-18 1970-06-17 L-alpha-hydrazino-beta-phenylpropionic acid compounds - decarboxylase inhibitors

Country Status (3)

Country Link
DK (1) DK138448C (en)
FI (1) FI54704C (en)
NL (1) NL7008881A (en)

Also Published As

Publication number Publication date
FI54704B (en) 1978-10-31
DK138448B (en) 1978-09-11
FI54704C (en) 1979-02-12
DK138448C (en) 1979-02-19

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