NL300728I2 - - Google Patents

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Publication number
NL300728I2
NL300728I2 NL300728C NL300728C NL300728I2 NL 300728 I2 NL300728 I2 NL 300728I2 NL 300728 C NL300728 C NL 300728C NL 300728 C NL300728 C NL 300728C NL 300728 I2 NL300728 I2 NL 300728I2
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NL
Netherlands
Prior art keywords
disclosed
compounds
conditions
btk
methods
Prior art date
Application number
NL300728C
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Dutch (nl)
Other versions
NL300728I1 (en
Original Assignee
Pharmacyclics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39225888&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL300728(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacyclics Inc filed Critical Pharmacyclics Inc
Publication of NL300728I1 publication Critical patent/NL300728I1/nl
Publication of NL300728I2 publication Critical patent/NL300728I2/nl

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Abstract

Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
NL300728C 2006-09-22 2015-04-03 NL300728I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82672006P 2006-09-22 2006-09-22
US82859006P 2006-10-06 2006-10-06
EP06850039.6A EP2081435B1 (en) 2006-09-22 2006-12-28 Inhibitors of bruton's tyrosine kinase

Publications (2)

Publication Number Publication Date
NL300728I1 NL300728I1 (en) 2016-01-26
NL300728I2 true NL300728I2 (en) 2016-01-26

Family

ID=39225888

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300728C NL300728I2 (en) 2006-09-22 2015-04-03

Country Status (28)

Country Link
US (48) US7514444B2 (en)
EP (11) EP2532235A1 (en)
JP (4) JP4934197B2 (en)
KR (4) KR20100051863A (en)
CN (4) CN101610676B (en)
AT (1) ATE531263T1 (en)
AU (2) AU2006348662B8 (en)
BR (2) BRPI0622054B8 (en)
CA (3) CA3180977A1 (en)
CY (11) CY1112513T1 (en)
DK (7) DK2526771T3 (en)
EA (3) EA024255B1 (en)
ES (8) ES2585902T3 (en)
FR (1) FR15C0029I2 (en)
HK (3) HK1129274A1 (en)
HU (10) HUE036897T2 (en)
IL (1) IL197550A0 (en)
LT (7) LT2529622T (en)
LU (3) LU92692I2 (en)
MX (3) MX347525B (en)
NL (1) NL300728I2 (en)
NZ (3) NZ601278A (en)
PL (8) PL2526933T3 (en)
PT (7) PT2081435T (en)
SG (2) SG166093A1 (en)
SI (8) SI2081435T1 (en)
WO (1) WO2008039218A2 (en)
ZA (4) ZA200901784B (en)

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ES2585902T3 (en) 2006-09-22 2016-10-10 Pharmacyclics Llc Bruton tyrosine kinase inhibitors
WO2008121742A2 (en) * 2007-03-28 2008-10-09 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
WO2008054827A2 (en) 2006-11-03 2008-05-08 Pharmacyclics, Inc. Bruton's tyrosine kinase activity probe and method of using
US20120101113A1 (en) * 2007-03-28 2012-04-26 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
CN101677991A (en) * 2007-04-12 2010-03-24 英菲尼蒂发现公司 hydroquinone ansamycin formulations
JP5600063B2 (en) 2007-10-19 2014-10-01 セルジーン アビロミクス リサーチ， インコーポレイテッド Heteroaryl compounds and uses thereof
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