NL2030897B1 - Antibiotic compounds, formulations and methods of use - Google Patents

Antibiotic compounds, formulations and methods of use Download PDF

Info

Publication number
NL2030897B1
NL2030897B1 NL2030897A NL2030897A NL2030897B1 NL 2030897 B1 NL2030897 B1 NL 2030897B1 NL 2030897 A NL2030897 A NL 2030897A NL 2030897 A NL2030897 A NL 2030897A NL 2030897 B1 NL2030897 B1 NL 2030897B1
Authority
NL
Netherlands
Prior art keywords
optionally substituted
group
pharmaceutically acceptable
polymyxin
compounds
Prior art date
Application number
NL2030897A
Other languages
English (en)
Dutch (nl)
Inventor
I Martin Nathaniel
Slingerland Jaco
Original Assignee
Univ Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leiden filed Critical Univ Leiden
Priority to NL2030897A priority Critical patent/NL2030897B1/en
Priority to CN202380025983.1A priority patent/CN118871454A/zh
Priority to CA3243809A priority patent/CA3243809A1/en
Priority to EP23706119.7A priority patent/EP4476239A1/en
Priority to US18/836,507 priority patent/US20250171498A1/en
Priority to JP2024547475A priority patent/JP2025505237A/ja
Priority to PCT/NL2023/050065 priority patent/WO2023153932A1/en
Application granted granted Critical
Publication of NL2030897B1 publication Critical patent/NL2030897B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NL2030897A 2022-02-11 2022-02-11 Antibiotic compounds, formulations and methods of use NL2030897B1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
NL2030897A NL2030897B1 (en) 2022-02-11 2022-02-11 Antibiotic compounds, formulations and methods of use
CN202380025983.1A CN118871454A (zh) 2022-02-11 2023-02-13 抗生素化合物、制剂和使用方法
CA3243809A CA3243809A1 (en) 2022-02-11 2023-02-13 ANTIBIOTIC COMPOUNDS, FORMULATIONS AND METHODS OF USE
EP23706119.7A EP4476239A1 (en) 2022-02-11 2023-02-13 Antibiotic compounds, formulations and methods of use
US18/836,507 US20250171498A1 (en) 2022-02-11 2023-02-13 Antibiotic compounds, formulations and methods of use
JP2024547475A JP2025505237A (ja) 2022-02-11 2023-02-13 抗生物質化合物、製剤および使用方法
PCT/NL2023/050065 WO2023153932A1 (en) 2022-02-11 2023-02-13 Antibiotic compounds, formulations and methods of use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL2030897A NL2030897B1 (en) 2022-02-11 2022-02-11 Antibiotic compounds, formulations and methods of use

Publications (1)

Publication Number Publication Date
NL2030897B1 true NL2030897B1 (en) 2023-08-18

Family

ID=85283807

Family Applications (1)

Application Number Title Priority Date Filing Date
NL2030897A NL2030897B1 (en) 2022-02-11 2022-02-11 Antibiotic compounds, formulations and methods of use

Country Status (7)

Country Link
US (1) US20250171498A1 (https=)
EP (1) EP4476239A1 (https=)
JP (1) JP2025505237A (https=)
CN (1) CN118871454A (https=)
CA (1) CA3243809A1 (https=)
NL (1) NL2030897B1 (https=)
WO (1) WO2023153932A1 (https=)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014012016A2 (pt) * 2011-11-18 2017-05-16 Cantab Anti-Infectives Ltd compostos
EP3636659A1 (en) * 2018-10-08 2020-04-15 Universitat de Barcelona Polymyxin-based compounds useful as antibacterial agents
WO2021150792A1 (en) * 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
CN118201946A (zh) * 2021-08-12 2024-06-14 奥克兰联合服务有限公司 脂化多粘菌素类似物

Also Published As

Publication number Publication date
JP2025505237A (ja) 2025-02-21
US20250171498A1 (en) 2025-05-29
CN118871454A (zh) 2024-10-29
CA3243809A1 (en) 2023-08-17
WO2023153932A1 (en) 2023-08-17
EP4476239A1 (en) 2024-12-18

Similar Documents

Publication Publication Date Title
JP5161269B2 (ja) 架橋されたグリコペプチド−セファロスポリン抗生物質
US8937040B2 (en) Antibiotic compositions for the treatment of gram negative infections
US8314217B2 (en) Cross-linked glycopeptide-cephalosporin antibiotics
KR20170125931A (ko) 면역조절제로서의 3-치환된 1,3,4-옥사다이아졸 및 티아다이아졸 화합물
CN103946233A (zh) 多黏菌素衍生物
PL198311B1 (pl) Związki glikopeptydowe, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie
US20180282374A1 (en) Antimicrobial polymyxin derivative compounds
AU2015213478B2 (en) Antibacterial agents
CN112789287A (zh) 化合物
US20160200768A1 (en) Vancomycin derivative, and preparation method and application thereof
EP1056771B1 (fr) Derives de streptogramines, leur preparation et les compositions qui les contiennent
RU2424248C2 (ru) Мономерные производные гликопептидного антибиотика
NL2030897B1 (en) Antibiotic compounds, formulations and methods of use
CA2949328C (en) Low substituted polymyxins and compositions thereof
EP4034547B1 (en) Antibiotic compounds
US11369586B2 (en) Antifungal peptoids