CN118871454A - 抗生素化合物、制剂和使用方法 - Google Patents

抗生素化合物、制剂和使用方法 Download PDF

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Publication number
CN118871454A
CN118871454A CN202380025983.1A CN202380025983A CN118871454A CN 118871454 A CN118871454 A CN 118871454A CN 202380025983 A CN202380025983 A CN 202380025983A CN 118871454 A CN118871454 A CN 118871454A
Authority
CN
China
Prior art keywords
optionally substituted
moiety
polymyxin
amino
substituted alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380025983.1A
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English (en)
Chinese (zh)
Inventor
N·I·马丁
J·斯林格兰德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universiteit Leiden
Original Assignee
Universiteit Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiteit Leiden filed Critical Universiteit Leiden
Publication of CN118871454A publication Critical patent/CN118871454A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202380025983.1A 2022-02-11 2023-02-13 抗生素化合物、制剂和使用方法 Pending CN118871454A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2030897A NL2030897B1 (en) 2022-02-11 2022-02-11 Antibiotic compounds, formulations and methods of use
NL2030897 2022-02-11
PCT/NL2023/050065 WO2023153932A1 (en) 2022-02-11 2023-02-13 Antibiotic compounds, formulations and methods of use

Publications (1)

Publication Number Publication Date
CN118871454A true CN118871454A (zh) 2024-10-29

Family

ID=85283807

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380025983.1A Pending CN118871454A (zh) 2022-02-11 2023-02-13 抗生素化合物、制剂和使用方法

Country Status (7)

Country Link
US (1) US20250171498A1 (https=)
EP (1) EP4476239A1 (https=)
JP (1) JP2025505237A (https=)
CN (1) CN118871454A (https=)
CA (1) CA3243809A1 (https=)
NL (1) NL2030897B1 (https=)
WO (1) WO2023153932A1 (https=)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014012016A2 (pt) * 2011-11-18 2017-05-16 Cantab Anti-Infectives Ltd compostos
EP3636659A1 (en) * 2018-10-08 2020-04-15 Universitat de Barcelona Polymyxin-based compounds useful as antibacterial agents
WO2021150792A1 (en) * 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
CN118201946A (zh) * 2021-08-12 2024-06-14 奥克兰联合服务有限公司 脂化多粘菌素类似物

Also Published As

Publication number Publication date
JP2025505237A (ja) 2025-02-21
US20250171498A1 (en) 2025-05-29
NL2030897B1 (en) 2023-08-18
CA3243809A1 (en) 2023-08-17
WO2023153932A1 (en) 2023-08-17
EP4476239A1 (en) 2024-12-18

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