JP2025505237A - 抗生物質化合物、製剤および使用方法 - Google Patents

抗生物質化合物、製剤および使用方法 Download PDF

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Publication number
JP2025505237A
JP2025505237A JP2024547475A JP2024547475A JP2025505237A JP 2025505237 A JP2025505237 A JP 2025505237A JP 2024547475 A JP2024547475 A JP 2024547475A JP 2024547475 A JP2024547475 A JP 2024547475A JP 2025505237 A JP2025505237 A JP 2025505237A
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JP
Japan
Prior art keywords
optionally substituted
moiety
polymyxin
amino
substituted alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024547475A
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English (en)
Japanese (ja)
Other versions
JP2025505237A5 (https=
Inventor
イー マルティン，ナタニエル
スリンガーラント，ヤコ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universiteit Leiden
Original Assignee
Universiteit Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Universiteit Leiden filed Critical Universiteit Leiden
Publication of JP2025505237A publication Critical patent/JP2025505237A/ja
Publication of JP2025505237A5 publication Critical patent/JP2025505237A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2024547475A 2022-02-11 2023-02-13 抗生物質化合物、製剤および使用方法 Pending JP2025505237A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2030897A NL2030897B1 (en) 2022-02-11 2022-02-11 Antibiotic compounds, formulations and methods of use
NL2030897 2022-02-11
PCT/NL2023/050065 WO2023153932A1 (en) 2022-02-11 2023-02-13 Antibiotic compounds, formulations and methods of use

Publications (2)

Publication Number Publication Date
JP2025505237A true JP2025505237A (ja) 2025-02-21
JP2025505237A5 JP2025505237A5 (https=) 2026-02-20

Family

ID=85283807

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024547475A Pending JP2025505237A (ja) 2022-02-11 2023-02-13 抗生物質化合物、製剤および使用方法

Country Status (7)

Country Link
US (1) US20250171498A1 (https=)
EP (1) EP4476239A1 (https=)
JP (1) JP2025505237A (https=)
CN (1) CN118871454A (https=)
CA (1) CA3243809A1 (https=)
NL (1) NL2030897B1 (https=)
WO (1) WO2023153932A1 (https=)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014012016A2 (pt) * 2011-11-18 2017-05-16 Cantab Anti-Infectives Ltd compostos
EP3636659A1 (en) * 2018-10-08 2020-04-15 Universitat de Barcelona Polymyxin-based compounds useful as antibacterial agents
WO2021150792A1 (en) * 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
CN118201946A (zh) * 2021-08-12 2024-06-14 奥克兰联合服务有限公司 脂化多粘菌素类似物

Also Published As

Publication number Publication date
US20250171498A1 (en) 2025-05-29
CN118871454A (zh) 2024-10-29
NL2030897B1 (en) 2023-08-18
CA3243809A1 (en) 2023-08-17
WO2023153932A1 (en) 2023-08-17
EP4476239A1 (en) 2024-12-18

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