NL2025687B1 - Superparamagnetic iron oxide nanoclusters and preparation method and application thereof - Google Patents
Superparamagnetic iron oxide nanoclusters and preparation method and application thereof Download PDFInfo
- Publication number
- NL2025687B1 NL2025687B1 NL2025687A NL2025687A NL2025687B1 NL 2025687 B1 NL2025687 B1 NL 2025687B1 NL 2025687 A NL2025687 A NL 2025687A NL 2025687 A NL2025687 A NL 2025687A NL 2025687 B1 NL2025687 B1 NL 2025687B1
- Authority
- NL
- Netherlands
- Prior art keywords
- solution
- iron oxide
- drying oven
- superparamagnetic iron
- dissolve
- Prior art date
Links
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 57
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 43
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 42
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 20
- 238000001035 drying Methods 0.000 claims description 19
- 239000002243 precursor Substances 0.000 claims description 16
- 238000005406 washing Methods 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 8
- 238000003860 storage Methods 0.000 claims description 8
- 238000001291 vacuum drying Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 4
- 235000017281 sodium acetate Nutrition 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- 239000001632 sodium acetate Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 abstract description 6
- 230000004044 response Effects 0.000 abstract description 6
- 238000002595 magnetic resonance imaging Methods 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 3
- 238000001027 hydrothermal synthesis Methods 0.000 abstract description 2
- 229940044631 ferric chloride hexahydrate Drugs 0.000 abstract 2
- NQXWGWZJXJUMQB-UHFFFAOYSA-K iron trichloride hexahydrate Chemical compound O.O.O.O.O.O.[Cl-].Cl[Fe+]Cl NQXWGWZJXJUMQB-UHFFFAOYSA-K 0.000 abstract 2
- 239000012046 mixed solvent Substances 0.000 abstract 1
- 238000004729 solvothermal method Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 25
- 239000002245 particle Substances 0.000 description 12
- 238000001514 detection method Methods 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 6
- 230000002378 acidificating effect Effects 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000002086 nanomaterial Substances 0.000 description 6
- 239000002105 nanoparticle Substances 0.000 description 6
- 238000003745 diagnosis Methods 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 238000003760 magnetic stirring Methods 0.000 description 4
- 229940031182 nanoparticles iron oxide Drugs 0.000 description 4
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000007885 magnetic separation Methods 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- -1 iron ions Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 230000005381 magnetic domain Effects 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 239000002122 magnetic nanoparticle Substances 0.000 description 1
- 230000005415 magnetization Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000593 microemulsion method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 238000004917 polyol method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 239000002096 quantum dot Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1887—Agglomerates, clusters, i.e. more than one (super)(para)magnetic microparticle or nanoparticle are aggregated or entrapped in the same maxtrix
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G49/00—Compounds of iron
- C01G49/02—Oxides; Hydroxides
- C01G49/08—Ferroso-ferric oxide [Fe3O4]
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/01—Particle morphology depicted by an image
- C01P2004/03—Particle morphology depicted by an image obtained by SEM
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compounds Of Iron (AREA)
Claims (3)
1. Een bereidingswerkwijze voor superparamagnetische ijzeroxide nanoclusters, omvattende de volgende stappen: (1) wegen van FeCl;s6H;0 in een reservoir, toevoegen van een ethyleenglycol (EG)-oplossing en een di-ethvleenglycol (DE G)-oplossing en magnetisch roeren om het FeCl;*6H,O op te lossen; (2) toevoegen van polyaerylzuur (PPA) aan een oplossing en roeren om de PPA op te lossen; (3) toevoegen van natriumacetaat (CH;COONa) en natriumhydroxide (NaOH); roeren en verwarmen om het CH;COONa en het NaOH op te lossen om een voorloper te vormen; (4) overbrengen van de bovenstaande voorloper naar een hydrothermische reactor; afdichten van de hydrothermische reactor, en vervolgens plaatsen in een sneldroogoven, verhitten tot 180- 280°C; en na 4-16 uur van reageren, sluiten van de sneldroogoven en op natuurlijke wijze laten afkoelen; en (5) uitnemen van een colloïdaal product, toevoegen van watervrije ethanol en water: ultrasoon wassen; scheiden met een magneet, en opnieuw wassen en scheiden met een zelfde methode; en plaatsen van een afgescheiden vaste stof in een vacuümdroogoven en drogen gedurende 12-36 uur bij kamertemperatuur: en afdichten van verkregen Fe30, droog poeder voor opslag.
2. De bereidingswerkwijze voor de superparamagnetische ijzeroxide nanoclusters volgens conclusie 1, waarbij een totaal volume van de EG- en DEG-oplossingen 30 ml is, en een verhouding van de EG-oplossing tot de DEG-oplossing 30/0-10/20 naar volume is.
3. De bereidingswerkwijze voor de superparamagnetische ijzeroxide nanoclusters volgens conclusie 1, omvattende: (1) wegen van FeCl;*6H,0 in een beker, toevoegen van een EG-oplossing en een DEG- oplossing, en magnetisch roeren gedurende 10 min om het FeCl;«6H,0 op te lossen; (2) toevoegen van PPA aan een oplossing en 30 min roeren om de PPA op te lossen; (3) toevoegen van CH;COONa en NaOH; 40 min roeren en verwarmen om het CH;COONa en het NaOH op te lossen om een voorloper te vormen;
(4) overbrengen van de bovenstaande voorloper naar een hydrothermische reactor; afdichten van de hydrothermische reactor; vervolgens plaatsen in een sneldroogoven, verhitten tot 210°C, en na 10 uur van reageren, sluiten van de sneldroogoven en op natuurlijke wijze laten afkoelen; en
(5) uitnemen van een colloïdaal product; toevoegen van watervrije ethanol en water; ultrasoon wassen, scheiden met een magneet: en opnieuw wassen en scheiden met een zelfde methode; en plaatsen van cen afgescheiden vaste stof in een vacuümdroogoven en drogen gedurende 24 uur bij kamertemperatuur; en afdichten van verkregen Fe;O, droog poeder voor opslag.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910697492.7A CN110384805A (zh) | 2019-07-30 | 2019-07-30 | 一种超顺磁性氧化铁纳米团簇体及其制备方法和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL2025687A NL2025687A (en) | 2020-07-23 |
| NL2025687B1 true NL2025687B1 (en) | 2021-06-08 |
Family
ID=68287850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL2025687A NL2025687B1 (en) | 2019-07-30 | 2020-05-27 | Superparamagnetic iron oxide nanoclusters and preparation method and application thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN110384805A (nl) |
| NL (1) | NL2025687B1 (nl) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102503870B1 (ko) * | 2021-01-08 | 2023-02-24 | 한밭대학교 산학협력단 | 온열치료용 산화철 나노 클러스터 및 이의 제조 방법 |
| CN113416538A (zh) * | 2021-06-23 | 2021-09-21 | 国家纳米科学中心 | 过渡金属氧化物纳米探针、制备方法及应用 |
| CN115924982A (zh) * | 2022-11-04 | 2023-04-07 | 济南大学 | 一种超小Fe3O4纳米颗粒自组装纳米团簇及其制备方法和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101805026A (zh) * | 2010-03-12 | 2010-08-18 | 南京大学 | 球形超顺磁四氧化三铁纳米簇的制法 |
-
2019
- 2019-07-30 CN CN201910697492.7A patent/CN110384805A/zh active Pending
-
2020
- 2020-05-27 NL NL2025687A patent/NL2025687B1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110384805A (zh) | 2019-10-29 |
| NL2025687A (en) | 2020-07-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL2025687B1 (en) | Superparamagnetic iron oxide nanoclusters and preparation method and application thereof | |
| Rezaei et al. | Magnetic nanoparticles: a review on synthesis, characterization, functionalization, and biomedical applications | |
| Bao et al. | Magnetic iron oxide nanoparticles as T 1 contrast agents for magnetic resonance imaging | |
| Huang et al. | Tunable T 1 and T 2 contrast abilities of manganese-engineered iron oxide nanoparticles through size control | |
| Park et al. | Transformation of hydrophobic iron oxide nanoparticles to hydrophilic and biocompatible maghemite nanocrystals for use as highly efficient MRI contrast agent | |
| Banerjee et al. | Synthesis, characterization, and evaluation of PEGylated first-row transition metal ferrite nanoparticles as T 2 contrast agents for high-field MRI | |
| Das et al. | Highly biocompatible and water-dispersible, amine functionalized magnetite nanoparticles, prepared by a low temperature, air-assisted polyol process: a new platform for bio-separation and diagnostics | |
| Pour et al. | Carboxymethyl cellulose (CMC)-loaded Co-Cu doped manganese ferrite nanorods as a new dual-modal simultaneous contrast agent for magnetic resonance imaging and nanocarrier for drug delivery system | |
| Shirinova et al. | Synthesis and characterization of magnetic nanocomposites for environmental remediation | |
| CZ301067B6 (cs) | Superparamagnetické nanocástice na bázi oxidu železa s modifikovaným povrchem, zpusob jejich prípravy a použití | |
| Li et al. | One-pot synthesis of polyamines improved magnetism and fluorescence Fe 3 O 4–carbon dots hybrid NPs for dual modal imaging | |
| Kačenka et al. | Dual imaging probes for magnetic resonance imaging and fluorescence microscopy based on perovskite manganite nanoparticles | |
| Lu et al. | Precise synthesis of discrete and dispersible carbon-protected magnetic nanoparticles for efficient magnetic resonance imaging and photothermal therapy | |
| Chen et al. | Assembly of Fe 3 O 4 nanoparticles on PEG-functionalized graphene oxide for efficient magnetic imaging and drug delivery | |
| CN109626439B (zh) | 一种金属掺杂铁氧体纳米材料、包含其的磁性纳米粒子的制备方法及其应用 | |
| Tang et al. | Synthesis of sub-100 nm biocompatible superparamagnetic Fe 3 O 4 colloidal nanocrystal clusters as contrast agents for magnetic resonance imaging | |
| Xu et al. | Superparamagnetic magnetite nanocrystal clusters: a sensitive tool for MR cellular imaging | |
| Li et al. | Highly sensitive magnetite nano clusters for MR cell imaging | |
| Avolio et al. | Elongated magnetic nanoparticles with high-aspect ratio: a nuclear relaxation and specific absorption rate investigation | |
| Yin et al. | Dysprosium-doped iron oxide nanoparticles boosting spin–spin relaxation: A computational and experimental study | |
| CN110664783B (zh) | 医用双壳层多孔结构空心纳米球及制备方法 | |
| Di et al. | Fluorescent and paramagnetic core–shell hybrid nanoparticles for bi-modal magnetic resonance/luminescence imaging | |
| Yue et al. | Ultrasmall europium, gadolinium, and dysprosium oxide nanoparticles: Polyol synthesis, properties, and biomedical imaging applications | |
| Zhou et al. | Synthesis and characterization of bracelet-like magnetic nanorings consisting of Ag–Fe 3 O 4 bi-component nanoparticles | |
| Yang et al. | Water-soluble magnetic CoO nanocrystals functionalized with surfactants as T 2-weighed MRI contrast agents in vitro |