NL2018855B1 - Laser line illuminator for high throughput sequencing - Google Patents
Laser line illuminator for high throughput sequencing Download PDFInfo
- Publication number
- NL2018855B1 NL2018855B1 NL2018855A NL2018855A NL2018855B1 NL 2018855 B1 NL2018855 B1 NL 2018855B1 NL 2018855 A NL2018855 A NL 2018855A NL 2018855 A NL2018855 A NL 2018855A NL 2018855 B1 NL2018855 B1 NL 2018855B1
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- Prior art keywords
- line
- light beam
- sample
- light
- imaging system
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S3/00—Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
- H01S3/23—Arrangements of two or more lasers not provided for in groups H01S3/02 - H01S3/22, e.g. tandem arrangements of separate active media
- H01S3/2383—Parallel arrangements
- H01S3/2391—Parallel arrangements emitting at different wavelengths
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- G—PHYSICS
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- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V13/00—Producing particular characteristics or distribution of the light emitted by means of a combination of elements specified in two or more of main groups F21V1/00 - F21V11/00
- F21V13/02—Combinations of only two kinds of elements
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V19/00—Fastening of light sources or lamp holders
- F21V19/02—Fastening of light sources or lamp holders with provision for adjustment, e.g. for focusing
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V31/00—Gas-tight or water-tight arrangements
- F21V31/04—Provision of filling media
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
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- G—PHYSICS
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- G02B21/08—Condensers
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- G—PHYSICS
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- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
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- G—PHYSICS
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- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
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- G02B27/09—Beam shaping, e.g. changing the cross-sectional area, not otherwise provided for
- G02B27/0927—Systems for changing the beam intensity distribution, e.g. Gaussian to top-hat
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
- G01N2021/392—Measuring reradiation, e.g. fluorescence, backscatter
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6478—Special lenses
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/0332—Cuvette constructions with temperature control
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
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- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Electromagnetism (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plasma & Fusion (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Microscoopes, Condenser (AREA)
- Liquid Crystal (AREA)
- Particle Accelerators (AREA)
- Lasers (AREA)
Priority Applications (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2018855A NL2018855B1 (en) | 2017-05-05 | 2017-05-05 | Laser line illuminator for high throughput sequencing |
| AU2018201388A AU2018201388B2 (en) | 2017-03-08 | 2018-02-26 | Laser Line Illuminator For High Throughput Sequencing |
| NZ740257A NZ740257A (en) | 2017-03-08 | 2018-02-26 | Laser line illuminator for high throughput sequencing |
| CA2996788A CA2996788C (en) | 2017-03-08 | 2018-02-27 | Laser line illuminator for high throughput sequencing |
| JP2018033475A JP6782268B2 (ja) | 2017-03-08 | 2018-02-27 | 高スループットシーケンシング用のレーザライン照明装置 |
| TW107106623A TWI721250B (zh) | 2017-03-08 | 2018-02-27 | 用於dna定序的成像系統 |
| MYPI2018000308A MY196535A (en) | 2017-03-08 | 2018-03-01 | Laser Line Illuminator for High Throughput Sequencing |
| IL257830A IL257830B2 (en) | 2017-03-08 | 2018-03-02 | Line laser source for continuous arrangement of the power |
| SG10201801707XA SG10201801707XA (en) | 2017-03-08 | 2018-03-02 | Laser line illuminator for high throughput sequencing |
| EP18160332.5A EP3373062A1 (en) | 2017-03-08 | 2018-03-06 | Laser line illuminator for high throughput sequencing |
| US15/913,420 US10774371B2 (en) | 2017-03-08 | 2018-03-06 | Laser line illuminator for high throughput sequencing |
| SA118390415A SA118390415B1 (ar) | 2017-03-08 | 2018-03-07 | مضيء خط ليزر لإجراء تسلسل عالي الإنتاجية |
| KR1020180027087A KR20180103014A (ko) | 2017-03-08 | 2018-03-07 | 하이 쓰루풋 시퀀싱을 위한 레이저 라인 조명기 |
| BR102018004635-7A BR102018004635B1 (pt) | 2017-03-08 | 2018-03-08 | Sistema de imageamento e sistema de sequenciamento de dna |
| CN201810191355.1A CN108572439B (zh) | 2017-03-08 | 2018-03-08 | 用于高通量测序的激光线照明器 |
| CN201820319958.0U CN208705562U (zh) | 2017-03-08 | 2018-03-08 | 成像系统和dna测序系统 |
| KR1020200000323A KR102394330B1 (ko) | 2017-03-08 | 2020-01-02 | 하이 스루풋 시퀀싱을 위한 레이저 라인 조명기 |
| JP2020081101A JP2020170165A (ja) | 2017-03-08 | 2020-05-01 | 高スループットシーケンシング用のレーザライン照明装置 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2018855A NL2018855B1 (en) | 2017-05-05 | 2017-05-05 | Laser line illuminator for high throughput sequencing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL2018855B1 true NL2018855B1 (en) | 2018-11-14 |
Family
ID=59974829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL2018855A NL2018855B1 (en) | 2017-03-08 | 2017-05-05 | Laser line illuminator for high throughput sequencing |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10774371B2 (https=) |
| EP (1) | EP3373062A1 (https=) |
| JP (2) | JP6782268B2 (https=) |
| KR (2) | KR20180103014A (https=) |
| CN (2) | CN208705562U (https=) |
| AU (1) | AU2018201388B2 (https=) |
| CA (1) | CA2996788C (https=) |
| IL (1) | IL257830B2 (https=) |
| MY (1) | MY196535A (https=) |
| NL (1) | NL2018855B1 (https=) |
| NZ (1) | NZ740257A (https=) |
| SA (1) | SA118390415B1 (https=) |
| SG (1) | SG10201801707XA (https=) |
| TW (1) | TWI721250B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201704771D0 (en) * | 2017-01-05 | 2017-05-10 | Illumina Inc | Modular optical analytic systems and methods |
| NL2018855B1 (en) * | 2017-05-05 | 2018-11-14 | Illumina Inc | Laser line illuminator for high throughput sequencing |
| CN111308680B (zh) * | 2018-12-11 | 2022-09-30 | 深圳华大生命科学研究院 | 线状照明装置和基因测序仪 |
| CN109370900A (zh) * | 2018-12-19 | 2019-02-22 | 深圳麦芽加速器科技有限公司 | 一种基因测序仪 |
| US11499924B2 (en) * | 2019-06-03 | 2022-11-15 | KLA Corp. | Determining one or more characteristics of light in an optical system |
| WO2021119201A1 (en) * | 2019-12-10 | 2021-06-17 | Enumerix, Inc. | Methods and systems for three-dimensional lightsheet imaging |
| US20210187503A1 (en) * | 2019-12-19 | 2021-06-24 | Personal Genomics Taiwan, Inc. | Apparatus and system for single-molecule nucleic acids detection |
| MX2021016073A (es) * | 2019-12-31 | 2022-03-25 | Illumina Inc | Funcionalidad de enfoque automático en el análisis óptico de muestras. |
| CN113155826B (zh) * | 2020-01-07 | 2024-08-27 | 深圳华大智造科技股份有限公司 | 检测装置 |
| US12259310B2 (en) * | 2020-06-10 | 2025-03-25 | Bgi Shenzhen | Biological sample image collection device and gene sequencer |
| EP4242291A4 (en) * | 2020-11-04 | 2024-08-07 | MGI Tech Co., Ltd. | Test system |
| US12379326B2 (en) * | 2021-05-17 | 2025-08-05 | The Trustees Of Columbia University In The City Of New York | Dark-field microscopy imaging apparatus |
| AU2022387406A1 (en) * | 2021-11-10 | 2024-05-02 | Illumina, Inc. | Apparatus and methods for controlling heating of an objective in a linescanning sequencing system to improve resolution |
| CN119546996A (zh) * | 2022-06-30 | 2025-02-28 | 伊鲁米纳公司 | 用于减少测序系统中的信号变化的设备 |
| US11723556B1 (en) | 2022-07-21 | 2023-08-15 | University Of Houston System | Instructional technologies for positioning a lower limb during muscular activity and detecting and tracking performance of a muscular activity |
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