NL2017270B1 - New anti-hCTLA-4 antibodies - Google Patents

New anti-hCTLA-4 antibodies Download PDF

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Publication number
NL2017270B1
NL2017270B1 NL2017270A NL2017270A NL2017270B1 NL 2017270 B1 NL2017270 B1 NL 2017270B1 NL 2017270 A NL2017270 A NL 2017270A NL 2017270 A NL2017270 A NL 2017270A NL 2017270 B1 NL2017270 B1 NL 2017270B1
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NL
Netherlands
Prior art keywords
antibody
antigen
binding fragment
seq
amino acid
Prior art date
Application number
NL2017270A
Other languages
English (en)
Dutch (nl)
Inventor
Van Eenennaam Hans
Van Elsas Andrea
Kreijtz Joost
Lutje Hulsik David
Vink Paul
Original Assignee
Aduro Biotech Holdings Europe B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL2017270A priority Critical patent/NL2017270B1/en
Application filed by Aduro Biotech Holdings Europe B V filed Critical Aduro Biotech Holdings Europe B V
Priority to CN201780060282.6A priority patent/CN110088134B/zh
Priority to PCT/IB2017/054697 priority patent/WO2018025178A1/en
Priority to EP17752494.9A priority patent/EP3494137B1/en
Priority to JP2019505381A priority patent/JP7214623B2/ja
Priority to TW106125917A priority patent/TW201808997A/zh
Priority to ARP170102189A priority patent/AR109276A1/es
Priority to ES17752494T priority patent/ES3038117T3/es
Priority to US15/665,858 priority patent/US10808030B2/en
Application granted granted Critical
Publication of NL2017270B1 publication Critical patent/NL2017270B1/en
Priority to JP2021166154A priority patent/JP7440473B2/ja

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NL2017270A 2016-08-02 2016-08-02 New anti-hCTLA-4 antibodies NL2017270B1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
NL2017270A NL2017270B1 (en) 2016-08-02 2016-08-02 New anti-hCTLA-4 antibodies
PCT/IB2017/054697 WO2018025178A1 (en) 2016-08-02 2017-08-01 Antibodies against human ctla-4
EP17752494.9A EP3494137B1 (en) 2016-08-02 2017-08-01 Antibodies against human ctla-4
JP2019505381A JP7214623B2 (ja) 2016-08-02 2017-08-01 ヒトctla-4に対する抗体
CN201780060282.6A CN110088134B (zh) 2016-08-02 2017-08-01 针对人ctla-4的抗体
TW106125917A TW201808997A (zh) 2016-08-02 2017-08-01 新型抗hCTLA-4抗體
ARP170102189A AR109276A1 (es) 2016-08-02 2017-08-01 ANTICUERPOS ANTI-hCTLA 4
ES17752494T ES3038117T3 (en) 2016-08-02 2017-08-01 Antibodies against human ctla-4
US15/665,858 US10808030B2 (en) 2016-08-02 2017-10-02 Anti-HCTLA-4 antibodies
JP2021166154A JP7440473B2 (ja) 2016-08-02 2021-10-08 ヒトctla-4に対する抗体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL2017270A NL2017270B1 (en) 2016-08-02 2016-08-02 New anti-hCTLA-4 antibodies

Publications (1)

Publication Number Publication Date
NL2017270B1 true NL2017270B1 (en) 2018-02-09

Family

ID=57104133

Family Applications (1)

Application Number Title Priority Date Filing Date
NL2017270A NL2017270B1 (en) 2016-08-02 2016-08-02 New anti-hCTLA-4 antibodies

Country Status (9)

Country Link
US (1) US10808030B2 (enExample)
EP (1) EP3494137B1 (enExample)
JP (2) JP7214623B2 (enExample)
CN (1) CN110088134B (enExample)
AR (1) AR109276A1 (enExample)
ES (1) ES3038117T3 (enExample)
NL (1) NL2017270B1 (enExample)
TW (1) TW201808997A (enExample)
WO (1) WO2018025178A1 (enExample)

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US20210332135A1 (en) * 2017-06-08 2021-10-28 Antibody Biopharm, Inc. Guided combinational therapeutic antibody

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CN110272490B (zh) * 2018-03-14 2021-05-14 上海开拓者生物医药有限公司 靶向ctla-4抗体、其制备方法和用途
CN112399973B (zh) * 2018-06-05 2022-12-16 江苏康宁杰瑞生物制药有限公司 二聚体及其用途
CN110760002A (zh) * 2018-07-25 2020-02-07 南京金斯瑞生物科技有限公司 人源化抗人ctla4单克隆抗体及其制备方法和用途
EP3617230A1 (en) 2018-09-03 2020-03-04 BioInvent International AB Novel antibodies and nucleotide sequences, and uses thereof
WO2020058762A1 (en) * 2018-09-20 2020-03-26 Tikcro Technologies Ltd Antibodies specific to ctla-4 and uses thereof
JP2022514702A (ja) 2018-12-21 2022-02-14 オーエスイー・イミュノセラピューティクス 二機能性抗pd-1/il-7分子
MX2021007848A (es) 2018-12-27 2021-10-26 Gigagen Inc Proteinas de union a anti-ctla-4 y metodos de uso de las mismas.
WO2020165374A1 (en) 2019-02-14 2020-08-20 Ose Immunotherapeutics Bifunctional molecule comprising il-15ra
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CN113121689B (zh) * 2020-01-16 2022-08-19 三优生物医药(上海)有限公司 Ctla-4结合分子及其用途
WO2021178611A1 (en) * 2020-03-05 2021-09-10 Merck Sharp & Dohme Corp. Methods for treating cancer or infection using a combination of an anti-pd-1 antibody, an anti-ctla4 antibody, and an anti-tigit antibody
WO2021178814A1 (en) 2020-03-06 2021-09-10 Regeneron Pharmaceuticals, Inc. Anti-gitr antibodies and uses thereof
JP2023518835A (ja) * 2020-03-26 2023-05-08 エショー バイオセラピー, インク. 制御性t細胞の除去用の二重特異性融合タンパク質
CN115443291B (zh) * 2020-04-13 2025-08-05 博奥信生物技术(南京)有限公司 结合ctla4的抗体及其用途
CN116813777A (zh) 2020-06-22 2023-09-29 恩格姆生物制药公司 Lair-1结合剂及其使用方法
IL298825A (en) * 2020-07-02 2023-02-01 Gigagen Inc ANTI-CTLA-4 binding proteins and methods of using them
CN115812081A (zh) * 2020-07-21 2023-03-17 上海君实生物医药科技股份有限公司 抗ctla-4抗体及其用途
CN114437228B (zh) * 2020-10-30 2024-02-06 中国科学院生物物理研究所 一种il-2与抗体亚单位构成的双功能融合蛋白
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