NL2000715A1 - Penem-prodrugs. - Google Patents

Penem-prodrugs.

Info

Publication number
NL2000715A1
NL2000715A1 NL2000715A NL2000715A NL2000715A1 NL 2000715 A1 NL2000715 A1 NL 2000715A1 NL 2000715 A NL2000715 A NL 2000715A NL 2000715 A NL2000715 A NL 2000715A NL 2000715 A1 NL2000715 A1 NL 2000715A1
Authority
NL
Netherlands
Prior art keywords
penem
prodrugs
penem prodrugs
Prior art date
Application number
NL2000715A
Other languages
English (en)
Other versions
NL2000715C2 (nl
Inventor
Katherine Elizabeth Brighty
Anthony Marfat
Dale Gordon Mcleod
John Paul O'donnell
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NL2000715A1 publication Critical patent/NL2000715A1/nl
Application granted granted Critical
Publication of NL2000715C2 publication Critical patent/NL2000715C2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/887—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hetero atom or a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
NL2000715A 2006-06-28 2007-06-19 Penem-prodrugs. NL2000715C2 (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80600006P 2006-06-28 2006-06-28
US80600006 2006-06-28
US91158707P 2007-04-13 2007-04-13
US91158707 2007-04-13

Publications (2)

Publication Number Publication Date
NL2000715A1 true NL2000715A1 (nl) 2008-01-02
NL2000715C2 NL2000715C2 (nl) 2008-03-11

Family

ID=38463109

Family Applications (1)

Application Number Title Priority Date Filing Date
NL2000715A NL2000715C2 (nl) 2006-06-28 2007-06-19 Penem-prodrugs.

Country Status (29)

Country Link
US (2) US7795243B2 (nl)
EP (1) EP2044085B1 (nl)
JP (2) JP4397435B2 (nl)
KR (1) KR101060448B1 (nl)
AP (1) AP2008004705A0 (nl)
AR (1) AR061646A1 (nl)
AT (1) ATE493419T1 (nl)
AU (1) AU2007263519B2 (nl)
BR (1) BRPI0712740A2 (nl)
CA (1) CA2655485C (nl)
CL (1) CL2007001910A1 (nl)
CR (1) CR10467A (nl)
DE (1) DE602007011622D1 (nl)
DK (1) DK2044085T3 (nl)
EA (1) EA200870584A1 (nl)
EC (1) ECSP088947A (nl)
GT (1) GT200700050A (nl)
HK (1) HK1134928A1 (nl)
IL (1) IL195383A0 (nl)
MA (1) MA30568B1 (nl)
MX (1) MX2009000116A (nl)
NL (1) NL2000715C2 (nl)
NO (1) NO20090392L (nl)
PE (1) PE20080940A1 (nl)
SV (1) SV2008003139A (nl)
TN (1) TNSN08537A1 (nl)
TW (1) TW200816999A (nl)
UY (1) UY30439A1 (nl)
WO (1) WO2008001212A2 (nl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20080940A1 (es) * 2006-06-28 2008-07-09 Pfizer Prod Inc Profarmacos de penem
US20080125408A1 (en) * 2006-11-14 2008-05-29 Pfizer Inc Penem prodrug
WO2009108704A1 (en) * 2008-02-25 2009-09-03 Semafore Pharmaceuticals, Inc. O-alkylated pi-3 kinase inhibitor prodrug combination
KR100916052B1 (ko) 2009-02-24 2009-09-08 코오롱건설주식회사 진공이송 쓰레기 수거시스템의 쓰레기 배출밸브
CA2768877A1 (en) * 2009-08-10 2011-02-17 Bellus Health Inc. Methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid
US11554112B2 (en) * 2018-06-07 2023-01-17 Herum Therapeutics International Limited Combinations of β-lactam compounds and probenecid and uses thereof
MX2021009755A (es) 2019-02-13 2021-11-17 Iterum Therapeutics International Ltd Combinaciones de compuestos beta-lactámicos y probenecid, y usos de los mismos.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619924A (en) * 1984-05-18 1986-10-28 Pfizer Inc. 2-alkylthiopenem derivatives
US4870170A (en) * 1985-10-17 1989-09-26 Pfizer Inc. Process for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics
US5013729A (en) * 1987-05-11 1991-05-07 Pfizer Inc. Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids
GB8713515D0 (en) 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
US4874877A (en) * 1988-04-19 1989-10-17 Pfizer Inc. Process for optically active 3-(methane-sulfonyloxy)thiolane and analogs
EP0544906B1 (en) 1990-08-20 1999-11-10 Suntory Limited Antibacterial penem esters derivatives
ATE172202T1 (de) 1990-08-20 1998-10-15 Suntory Ltd Antibakterielle penemverbindungen
WO2004067532A1 (ja) 2003-01-31 2004-08-12 Meiji Seika Kaisha, Ltd. 新規カルバペネム誘導体
PE20080940A1 (es) * 2006-06-28 2008-07-09 Pfizer Prod Inc Profarmacos de penem
EP2043728A2 (en) * 2006-07-11 2009-04-08 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
US20080125408A1 (en) * 2006-11-14 2008-05-29 Pfizer Inc Penem prodrug

Also Published As

Publication number Publication date
CL2007001910A1 (es) 2008-01-11
GT200700050A (es) 2008-02-01
KR20090015147A (ko) 2009-02-11
MA30568B1 (fr) 2009-07-01
US20090042853A1 (en) 2009-02-12
JP2009542616A (ja) 2009-12-03
CA2655485A1 (en) 2008-01-03
NO20090392L (no) 2009-01-27
CA2655485C (en) 2011-08-02
EA200870584A1 (ru) 2009-06-30
TW200816999A (en) 2008-04-16
DK2044085T3 (da) 2011-03-07
ECSP088947A (es) 2009-01-30
US20080009474A1 (en) 2008-01-10
AR061646A1 (es) 2008-09-10
WO2008001212A2 (en) 2008-01-03
NL2000715C2 (nl) 2008-03-11
HK1134928A1 (en) 2010-05-20
PE20080940A1 (es) 2008-07-09
AU2007263519B2 (en) 2011-05-19
UY30439A1 (es) 2008-01-31
JP5152527B2 (ja) 2013-02-27
EP2044085A2 (en) 2009-04-08
ATE493419T1 (de) 2011-01-15
JP4397435B2 (ja) 2010-01-13
AP2008004705A0 (en) 2008-12-31
CR10467A (es) 2009-01-19
IL195383A0 (en) 2009-08-03
KR101060448B1 (ko) 2011-08-29
US7795243B2 (en) 2010-09-14
WO2008001212A3 (en) 2008-03-20
JP2010013468A (ja) 2010-01-21
US7795244B2 (en) 2010-09-14
BRPI0712740A2 (pt) 2012-06-05
TNSN08537A1 (fr) 2010-04-14
DE602007011622D1 (en) 2011-02-10
MX2009000116A (es) 2009-01-23
SV2008003139A (es) 2010-01-12
EP2044085B1 (en) 2010-12-29
AU2007263519A1 (en) 2008-01-03

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Legal Events

Date Code Title Description
AD1A A request for search or an international type search has been filed
RD2N Patents in respect of which a decision has been taken or a report has been made (novelty report)

Effective date: 20080110

PD2B A search report has been drawn up
V1 Lapsed because of non-payment of the annual fee

Effective date: 20110101