NL191208C - 4-Amino-6,7-dimethoxy-2-[4-(gesubstitueerd carbonyl)-1-piperazinylchinazoline-verbindingen met hypertensie bestrijdende werkzaamheid en farmaceutische preparaten, die deze verbindingen bevatten. - Google Patents

4-Amino-6,7-dimethoxy-2-[4-(gesubstitueerd carbonyl)-1-piperazinylchinazoline-verbindingen met hypertensie bestrijdende werkzaamheid en farmaceutische preparaten, die deze verbindingen bevatten.

Info

Publication number
NL191208C
NL191208C NL8100726A NL8100726A NL191208C NL 191208 C NL191208 C NL 191208C NL 8100726 A NL8100726 A NL 8100726A NL 8100726 A NL8100726 A NL 8100726A NL 191208 C NL191208 C NL 191208C
Authority
NL
Netherlands
Prior art keywords
compounds
piperazinylquinazoline
dimethoxy
amino
pharmaceutical compositions
Prior art date
Application number
NL8100726A
Other languages
English (en)
Dutch (nl)
Other versions
NL191208B (nl
NL8100726A (nl
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1677580A external-priority patent/JPS56113770A/ja
Priority claimed from JP5275480A external-priority patent/JPS56150072A/ja
Priority claimed from JP9610680A external-priority patent/JPS5721384A/ja
Priority claimed from JP9610780A external-priority patent/JPS5721385A/ja
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of NL8100726A publication Critical patent/NL8100726A/nl
Publication of NL191208B publication Critical patent/NL191208B/xx
Application granted granted Critical
Publication of NL191208C publication Critical patent/NL191208C/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL8100726A 1980-02-13 1981-02-13 4-Amino-6,7-dimethoxy-2-[4-(gesubstitueerd carbonyl)-1-piperazinylchinazoline-verbindingen met hypertensie bestrijdende werkzaamheid en farmaceutische preparaten, die deze verbindingen bevatten. NL191208C (nl)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP1677580 1980-02-13
JP1677580A JPS56113770A (en) 1980-02-13 1980-02-13 Novel quinazoline derivative and its preparation
JP5275480A JPS56150072A (en) 1980-04-21 1980-04-21 Novel quinazoline derivative and its preparation
JP5275480 1980-04-21
JP9610780 1980-07-14
JP9610680 1980-07-14
JP9610680A JPS5721384A (en) 1980-07-14 1980-07-14 Novel aminoquinazoline derivative and its preparation
JP9610780A JPS5721385A (en) 1980-07-14 1980-07-14 Novel aminoquinazoline derivative and its preparation

Publications (3)

Publication Number Publication Date
NL8100726A NL8100726A (nl) 1981-09-16
NL191208B NL191208B (nl) 1994-10-17
NL191208C true NL191208C (nl) 1995-03-16

Family

ID=27456647

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8100726A NL191208C (nl) 1980-02-13 1981-02-13 4-Amino-6,7-dimethoxy-2-[4-(gesubstitueerd carbonyl)-1-piperazinylchinazoline-verbindingen met hypertensie bestrijdende werkzaamheid en farmaceutische preparaten, die deze verbindingen bevatten.

Country Status (9)

Country Link
US (1) US4426382A (enExample)
CA (1) CA1154765A (enExample)
CH (1) CH644857A5 (enExample)
DE (1) DE3105330A1 (enExample)
ES (1) ES499377A0 (enExample)
FR (1) FR2475548A1 (enExample)
GB (1) GB2068961B (enExample)
IT (1) IT1172225B (enExample)
NL (1) NL191208C (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS236097B1 (en) * 1983-06-01 1985-05-15 Jan Koenig Acylderivatives of 2-piperazinochinazoline and method of their preparation
DE3346675A1 (de) * 1983-12-23 1985-07-04 Beiersdorf Ag, 2000 Hamburg Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte
JPH0647540B2 (ja) * 1985-07-16 1994-06-22 エーザイ株式会社 虚血性心疾患・不整脈治療・予防剤
IT1270993B (it) * 1994-03-18 1997-05-26 Recordati Chem Pharm Derivati chinzolilamminici attivi come alfa-antagonisti
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
JP2009531447A (ja) * 2006-03-29 2009-09-03 メルク エンド カムパニー インコーポレーテッド ジアゼパンオレキシン受容体アンタゴニスト
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
CA2687931C (en) 2007-05-31 2016-05-24 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists and uses thereof
US20090325964A1 (en) * 2008-05-23 2009-12-31 Wyeth Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression
ES2551557T3 (es) 2008-12-19 2015-11-19 Boehringer Ingelheim International Gmbh Pirimidin-4-carboxamidas cíclicas como antagonistas del receptor CCR2 para el tratamiento de inflamaciones, asma y EPOC
PL2513093T3 (pl) 2009-12-17 2015-03-31 Centrexion Therapeutics Corp Nowi antagoniści receptora CCR2 i ich zastosowanie
WO2011141474A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2569295B1 (en) 2010-05-12 2014-11-19 Boehringer Ingelheim International GmbH New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2571870B1 (en) 2010-05-17 2015-01-21 Boehringer Ingelheim International GmbH Ccr2 antagonists and uses thereof
US9018212B2 (en) 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
JP5721242B2 (ja) 2010-06-01 2015-05-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２アンタゴニスト
JP5786258B2 (ja) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規かつ選択的なｃｃｒ２拮抗薬
WO2013144180A1 (en) * 2012-03-28 2013-10-03 Intervet International B.V. Heteroaryl compounds with cyclic bridging unit for use in the treatment helminth infection
CA2877526A1 (en) 2012-06-20 2013-12-27 Novartis Ag Complement pathway modulators and uses thereof
WO2015095111A1 (en) 2013-12-18 2015-06-25 Merck Sharp & Dohme Corp. Diazepane orexin receptor antagonists
MX383744B (es) 2015-07-02 2025-03-14 Centrexion Therapeutics Corp Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona.
US11944624B2 (en) * 2017-07-06 2024-04-02 Case Western Reserve University Peptide and small molecule agonists of EphA and their uses

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3635979A (en) 1969-09-29 1972-01-18 Pfizer Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
JPS4966691A (enExample) * 1972-10-30 1974-06-27
US3935213A (en) 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
US4060615A (en) * 1976-02-18 1977-11-29 Mead Johnson & Company 2-Piperazinyl-6,7-dimethoxyquinazolines
US4001237A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company Oxazole, isoxazole, thiazole and isothiazole amides
US4189484A (en) * 1977-11-08 1980-02-19 Mitsubishi Yuka Pharmaceutical Co., Ltd. Antihypertensive quinazoline derivatives
US4287341A (en) 1979-11-01 1981-09-01 Pfizer Inc. Alkoxy-substituted-6-chloro-quinazoline-2,4-diones
JPS5728576A (en) * 1980-07-24 1982-02-16 Toshiba Corp Inverter device

Also Published As

Publication number Publication date
CH644857A5 (de) 1984-08-31
DE3105330A1 (de) 1981-12-17
NL191208B (nl) 1994-10-17
IT8167213A0 (it) 1981-02-13
NL8100726A (nl) 1981-09-16
GB2068961A (en) 1981-08-19
ES8207169A1 (es) 1982-09-01
CA1154765A (en) 1983-10-04
ES499377A0 (es) 1982-09-01
IT1172225B (it) 1987-06-18
FR2475548B1 (enExample) 1983-06-24
FR2475548A1 (fr) 1981-08-14
DE3105330C2 (enExample) 1991-07-25
GB2068961B (en) 1983-11-30
US4426382A (en) 1984-01-17

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
V1 Lapsed because of non-payment of the annual fee

Effective date: 19950901