NL165170C - Werkwijze ter bereiding van een antibiotisch wekzaam preparaat en werkwijze ter bereiding van cefalosporine- derivaten. - Google Patents

Werkwijze ter bereiding van een antibiotisch wekzaam preparaat en werkwijze ter bereiding van cefalosporine- derivaten.

Info

Publication number
NL165170C
NL165170C NL7005519.A NL7005519A NL165170C NL 165170 C NL165170 C NL 165170C NL 7005519 A NL7005519 A NL 7005519A NL 165170 C NL165170 C NL 165170C
Authority
NL
Netherlands
Prior art keywords
preparing
sophic
antibiotic
preparation
cephalosporine derivatives
Prior art date
Application number
NL7005519.A
Other languages
English (en)
Other versions
NL165170B (nl
NL7005519A (nl
Inventor
Ryan Charles Wilbur
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NL7005519A publication Critical patent/NL7005519A/xx
Publication of NL165170B publication Critical patent/NL165170B/nl
Application granted granted Critical
Publication of NL165170C publication Critical patent/NL165170C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
NL7005519.A 1969-04-18 1970-04-16 Werkwijze ter bereiding van een antibiotisch wekzaam preparaat en werkwijze ter bereiding van cefalosporine- derivaten. NL165170C (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US817556A US3641021A (en) 1969-04-18 1969-04-18 3 7-(ring-substituted) cephalosporin compounds

Publications (3)

Publication Number Publication Date
NL7005519A NL7005519A (nl) 1970-10-20
NL165170B NL165170B (nl) 1980-10-15
NL165170C true NL165170C (nl) 1981-03-16

Family

ID=25223346

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7005519.A NL165170C (nl) 1969-04-18 1970-04-16 Werkwijze ter bereiding van een antibiotisch wekzaam preparaat en werkwijze ter bereiding van cefalosporine- derivaten.

Country Status (24)

Country Link
US (1) US3641021A (nl)
JP (3) JPS4945880B1 (nl)
BR (1) BR6915448D0 (nl)
CH (1) CH540293A (nl)
CS (2) CS185600B2 (nl)
CY (1) CY775A (nl)
DE (1) DE2018600C3 (nl)
DK (1) DK132119C (nl)
ES (1) ES378765A1 (nl)
FI (1) FI51201C (nl)
FR (1) FR2042346B1 (nl)
GB (1) GB1283811A (nl)
IL (1) IL34285A (nl)
LU (1) LU60751A1 (nl)
MY (1) MY7500031A (nl)
NL (1) NL165170C (nl)
NO (2) NO138807C (nl)
OA (1) OA03254A (nl)
PH (1) PH11309A (nl)
PL (1) PL80605B1 (nl)
SE (2) SE377127B (nl)
SU (1) SU378014A3 (nl)
YU (1) YU36528B (nl)
ZA (1) ZA702290B (nl)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
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US3932465A (en) * 1970-07-08 1976-01-13 Ciba-Geigy Corporation 3-R-methyl-7-amino-ceph-em-4-carboxylic acid compounds
JPS4948559B1 (nl) * 1970-11-10 1974-12-21
US3867380A (en) * 1971-02-18 1975-02-18 Smithkline Corp 3-Heterocyclic thiomethylcephalosporins
US3987041A (en) * 1970-12-17 1976-10-19 Smithkline Corporation P-hydroxymethylphenylacetamidocephalosporins
US3855213A (en) * 1971-02-18 1974-12-17 Smith Kline French Lab 3-heterocyclic thiomethyl-cephalosporins
NL7200588A (nl) * 1971-01-18 1972-07-20
IE36221B1 (en) * 1971-04-21 1976-09-15 Ciba Geigy Ag Acylamino compounds and a process for their manufacture
US3757014A (en) * 1971-05-07 1973-09-04 Bristol Myers Co Ts 1,3,4 - oxadiazol-2-yl)thiomethyl)-3-cephem-4-carboxylic acid and sal7-(d-(alpha-amino-alpha-pheyle-acetamido)) - 3-(s-(5-hydroxymethyl -
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
US3903278A (en) * 1971-11-04 1975-09-02 Smithkline Corp Method of combating enterobacter infections
CA999574A (en) * 1972-06-14 1976-11-09 Smith Kline And French Canada Ltd. 7-hydroxyhalophenylacetamido-3-h heterocyclicthiomethyl cephalosporins
CA1076560A (en) * 1972-06-14 1980-04-29 Smith Kline And French Canada Ltd. 3-heterocyclic thiomethylcephalosporins
US3968226A (en) * 1972-06-14 1976-07-06 Smithkline Corporation 3-Heterocyclic thiomethylcephalosporins as antibacterial agents
US3828037A (en) * 1972-07-20 1974-08-06 Smithkline Corp Trifluoromethylmercaptoacetamidocephalosporins
US3855212A (en) * 1972-08-04 1974-12-17 Squibb & Sons Inc Cyanomethylth ioacetylcephalosporins
US3957768A (en) * 1972-11-14 1976-05-18 Smithkline Corporation 3-heterocyclicthiomethylcephalosporins
GB1438872A (en) * 1972-11-17 1976-06-09 Fujisawa Pharmaceutical Co 7-beta-aminoacylamino-3-substituted-3-cephem-4-carboxylic acid derivatives and preparation thereof
YU36970B (en) * 1973-02-23 1984-08-31 Lilly Co Eli Process for obtaining 7-(amino)-acylamido-3-halocephalosporins
AR207752A1 (es) * 1973-03-30 1976-10-29 Fujisawa Pharmaceutical Co Procedimiento para obtener acidos 7-amino-sustituido-3-tiometilsustituido-3-cefem-4-carboxilicos
US4007173A (en) * 1973-05-07 1977-02-08 Smithkline Corporation α-amino-α-(ureidophenyl)acetamidocephalosporins
AR205537A1 (es) * 1973-05-10 1976-05-14 Fujisawa Pharmaceutical Co Procedimiento para la preparacion de derivados de acido 7-substituido fenilglicinamido - 3 - substituido - 3 - cefem - 4 - carboxilicos
US3962230A (en) * 1973-05-11 1976-06-08 Smithkline & French Laboratories, Inc. P-hydroxymethylphenylacetamidocephalosporins
US3879385A (en) * 1973-05-16 1975-04-22 American Home Prod 3-(Alpha-trifluoromethylarylacetamido)-1,4-cyclo(1,-carboxyl)alkylenethio)-azetidin-2-one derivatives
US4000133A (en) * 1973-06-06 1976-12-28 Fujisawa Pharmaceutical Co., Ltd. Substituted 7-styryl-carbonyloxy-acetamido cephalosporanic
US3884914A (en) * 1973-07-05 1975-05-20 Smithkline Corp Mandelamidocephalosporins with improved properties
US3957985A (en) * 1973-07-05 1976-05-18 Smithkline Corporation Mandelamidocephalosporins with improved properties
US4022895A (en) * 1973-08-01 1977-05-10 Smithkline Corporation Substituted phenylglycylcephalosporins
US3883520A (en) * 1973-08-17 1975-05-13 Smithkline Corp Substituted mercaptoacetamidocephalosporins
US3957984A (en) * 1973-08-17 1976-05-18 Smithkline Corporation Substituted mercaptoacetamidocephalosporins
HU172234B (hu) * 1973-12-21 1978-07-28 Glaxo Lab Ltd Sposob poluchenija novykh proizvodnykh 7-beta-acilamido-cef-3-em-4-karbonovojj kisloty
DE2407715C2 (de) * 1974-02-18 1982-12-02 Bayer Ag, 5090 Leverkusen Cephalosporine, Verfahren zu ihrer Herstellung sowie Arzneimittel
US4205166A (en) * 1974-02-20 1980-05-27 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted-3-aminoalkyl-, acylaminoalkyl-, or hydroxyalkyl-substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof
US3928592A (en) * 1974-02-22 1975-12-23 Lilly Co Eli Antibiotic pharmaceutical compositions
JPS5729475B2 (nl) * 1974-04-11 1982-06-23
US3956292A (en) * 1974-04-01 1976-05-11 Eli Lilly And Company 7-(α-FUROYLUREIDOARYL AND CYCLOHEXADIENYLACETAMIDO) CEPHALOSPORIN ANTIBIOTICS
US3925368A (en) * 1974-04-01 1975-12-09 Lilly Co Eli Acylureido substituted cephalosporins
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
GB1476981A (en) * 1974-06-05 1977-06-16 Bristol Myers Co Substituted penicillanic acids
US3928334A (en) * 1974-06-06 1975-12-23 Bristol Myers Co Process for the production of cefamandole
JPS612674B2 (nl) * 1974-06-20 1986-01-27 Meiji Seika Co
US3928337A (en) * 1974-08-07 1975-12-23 Bristol Myers Co Process for the production of cefamandole
CA1074784A (en) * 1974-09-06 1980-04-01 Sumitomo Chemical Company N-ACYLAMINO-.alpha.-ARYLACETAMIDO CEPHALOSPORINS
US4088815A (en) * 1974-09-20 1978-05-09 E. R. Squibb & Sons, Inc. 3-Heterothio-7-ureido cephalosporins
BE833640A (fr) * 1974-09-20 1976-03-19 Nouvelles cephalosporines et leur preparation
US4018759A (en) * 1974-12-03 1977-04-19 Smithkline Corporation 3-Heterocyclicthiomethylcephalosporins
US3992377A (en) * 1974-12-13 1976-11-16 Eli Lilly And Company 3-Thio-substituted cephalosporin antibiotics
DK43476A (da) * 1975-02-04 1976-08-05 Fujisawa Pharmaceutical Co Fremgangsmade til fremstilling af cephemcarboxylsyrer
IE44607B1 (en) * 1975-03-18 1982-01-27 Smithkline Corp Cephalosporin compounds
US4006138A (en) * 1975-04-11 1977-02-01 Eli Lilly And Company Crystalline form of sodium O-formylcefamandole
US4111981A (en) * 1975-12-15 1978-09-05 Smithkline Corporation Intermediates for preparing substituted phenylglycylcephalosporins
US4054738A (en) * 1975-12-22 1977-10-18 Eli Lilly And Company Sodium cefamandole crystalline forms
US4127716A (en) * 1976-03-08 1978-11-28 E. R. Squibb & Sons, Inc. 3-heterothiomethyl ureido cephalosporins
US4035361A (en) * 1976-03-17 1977-07-12 Eli Lilly And Company Bis-trimethylsilyl cefamandole and process therefor
US4063019A (en) 1976-03-30 1977-12-13 E. R. Squibb & Sons, Inc. [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
US4112228A (en) * 1976-07-13 1978-09-05 Bristol-Myers Company 7-(D-α-Hydroxy-2-arylacetamido)-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo-[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids and derivatives
JPS5321191A (en) * 1976-08-10 1978-02-27 Shionogi & Co Ltd 7-arylmalonamidocephem derivatives
US4144391A (en) * 1977-03-07 1979-03-13 Eli Lilly And Company Cephalosporin displacement reaction
IL54181A (en) * 1977-03-07 1981-03-31 Lilly Co Eli Preparation of 3-(thiomethyl)cephalosporins
US4115644A (en) * 1977-09-19 1978-09-19 Eli Lilly And Company Process for preparing pure cefamandole from alkali metal and ammonium salts thereof
AR223653A1 (es) * 1977-09-27 1981-09-15 Toyama Chemical Co Ltd Procedimiento de preparacion del acido 7-(d(-)-alpha-(4-etil-2,3-dioxo-1-piperazinocarboxamido)-alpha-(4-hidroxifenil)acetamido)-3-(5-(1-metil-1,2,3,4-tetrazolil)tiometil)-delta3-cefem-4-carboxilico y su producto de adicion con n,n-dimetilacetamida
US4168376A (en) * 1978-06-05 1979-09-18 Eli Lilly And Company Process for crystalline sodium cefamandole
US4223135A (en) * 1979-03-19 1980-09-16 Bristol-Myers Company Production of cephalosporins
US4316016A (en) * 1979-03-19 1982-02-16 Bristol-Myers Company Cephalosporin intermediates
US4316017A (en) * 1979-03-19 1982-02-16 Bristol-Myers Company Cephalosporin intermediates
JPS55139387A (en) * 1979-04-19 1980-10-31 Yamanouchi Pharmaceut Co Ltd Novel synthetic method of 7-amino-3-heterocyclic thiomethyl-delta3-carboxylic acids
EP0137227B1 (en) * 1980-09-02 1987-12-16 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of cephalosporin derivatives using novel thioesters
JPS5988490A (ja) * 1982-11-10 1984-05-22 Kyoto Yakuhin Kogyo Kk セフアロスポリン誘導体
US4737492A (en) * 1986-12-31 1988-04-12 Alcon Laboratories, Inc. Sparingly soluble salts of cefamandole, and ophthalmic compositions containing same
JPH0354585U (nl) * 1989-09-29 1991-05-27
US5318781A (en) * 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
FR2876379B1 (fr) * 2004-10-08 2008-09-05 Isochem Sa Procede de polymerisation des o-carboxy anhydrides
WO2013057197A1 (en) 2011-10-20 2013-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the formylation of cefamandole
WO2013057196A1 (en) 2011-10-20 2013-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of cefamandole nafate
CN104193767B (zh) * 2014-08-07 2016-07-06 杭州长典医药科技有限公司 一种头孢孟多酯钠超细粉体制剂及其制备方法

Also Published As

Publication number Publication date
ZA702290B (en) 1971-11-24
NO781312L (no) 1970-10-20
IL34285A0 (en) 1970-06-17
DK132119C (da) 1976-04-20
NL165170B (nl) 1980-10-15
ES378765A1 (es) 1972-07-16
PL80605B1 (nl) 1975-08-30
IL34285A (en) 1973-10-25
NL7005519A (nl) 1970-10-20
CH540293A (de) 1973-08-15
SU378014A3 (nl) 1973-04-17
YU99670A (en) 1982-02-25
CY775A (en) 1975-03-01
DE2018600B2 (de) 1975-01-02
GB1283811A (en) 1972-08-02
JPS5231356B1 (nl) 1977-08-13
NO138807B (no) 1978-08-07
NO138807C (no) 1978-11-15
DE2018600C3 (de) 1975-07-31
OA03254A (fr) 1970-12-15
FR2042346A1 (nl) 1971-02-12
FI51201C (fi) 1976-11-10
US3641021A (en) 1972-02-08
DE2018600A1 (de) 1970-11-05
FI51201B (nl) 1976-08-02
LU60751A1 (nl) 1970-11-17
MY7500031A (en) 1975-12-31
FR2042346B1 (nl) 1973-12-21
PH11309A (en) 1977-11-02
CS185600B2 (en) 1978-10-31
SE377127B (nl) 1975-06-23
JPS5537997B1 (nl) 1980-10-01
JPS4945880B1 (nl) 1974-12-06
YU36528B (en) 1984-02-29
BR6915448D0 (pt) 1973-03-13
SE405251B (sv) 1978-11-27
CS185558B2 (en) 1978-10-31
DK132119B (da) 1975-10-27

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Legal Events

Date Code Title Description
V4 Discontinued because of reaching the maximum lifetime of a patent