NL142402B - Werkwijze voor het bereiden van verbindingen met de cholesterolspiegel verlagende eigenschappen. - Google Patents
Werkwijze voor het bereiden van verbindingen met de cholesterolspiegel verlagende eigenschappen.Info
- Publication number
- NL142402B NL142402B NL656503266A NL6503266A NL142402B NL 142402 B NL142402 B NL 142402B NL 656503266 A NL656503266 A NL 656503266A NL 6503266 A NL6503266 A NL 6503266A NL 142402 B NL142402 B NL 142402B
- Authority
- NL
- Netherlands
- Prior art keywords
- compound
- general formula
- methylhydantoin
- diiodo
- acylated
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title 2
- 235000012000 cholesterol Nutrition 0.000 title 1
- 230000001603 reducing effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
- VMAQYKGITHDWKL-UHFFFAOYSA-N 5-Methyl hydantoin Natural products CC1NC(=O)NC1=O VMAQYKGITHDWKL-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 239000012670 alkaline solution Substances 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 abstract 1
- 229940091173 hydantoin Drugs 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000026045 iodination Effects 0.000 abstract 1
- 238000006192 iodination reaction Methods 0.000 abstract 1
- 125000002346 iodo group Chemical group I* 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000010792 warming Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEC0032613 | 1964-04-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL6503266A NL6503266A (enrdf_load_stackoverflow) | 1965-10-11 |
| NL142402B true NL142402B (nl) | 1974-06-17 |
Family
ID=7020410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL656503266A NL142402B (nl) | 1964-04-10 | 1965-03-15 | Werkwijze voor het bereiden van verbindingen met de cholesterolspiegel verlagende eigenschappen. |
Country Status (13)
-
1965
- 1965-03-08 AT AT372066A patent/AT268553B/de active
- 1965-03-08 AT AT371966A patent/AT268552B/de active
- 1965-03-08 AT AT203465A patent/AT268547B/de active
- 1965-03-11 DE DE19651793776 patent/DE1793776A1/de active Pending
- 1965-03-15 NL NL656503266A patent/NL142402B/xx unknown
- 1965-04-01 GB GB13872/65A patent/GB1100643A/en not_active Expired
- 1965-04-05 FI FI650814A patent/FI43439C/fi active
- 1965-04-07 CH CH480865A patent/CH469664A/de unknown
- 1965-04-08 BE BE662271A patent/BE662271A/xx unknown
- 1965-04-09 DK DK183165AA patent/DK123229B/da unknown
- 1965-04-09 SE SE04627/65A patent/SE332994B/xx unknown
- 1965-04-09 OA OA51586A patent/OA01689A/xx unknown
- 1965-04-09 BR BR168876/65A patent/BR6568876D0/pt unknown
- 1965-04-09 ES ES0311669A patent/ES311669A1/es not_active Expired
- 1965-04-09 FR FR1587317D patent/FR1587317A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1100643A (en) | 1968-01-24 |
| DE1793776A1 (de) | 1974-08-29 |
| OA01689A (fr) | 1969-12-15 |
| FI43439B (enrdf_load_stackoverflow) | 1970-12-31 |
| ES311669A1 (es) | 1965-07-01 |
| NL6503266A (enrdf_load_stackoverflow) | 1965-10-11 |
| BR6568876D0 (pt) | 1973-08-07 |
| AT268552B (de) | 1969-02-10 |
| AT268547B (de) | 1969-02-10 |
| SE332994B (enrdf_load_stackoverflow) | 1971-03-01 |
| AT268553B (de) | 1969-02-10 |
| DK123229B (da) | 1972-05-29 |
| FR1587317A (enrdf_load_stackoverflow) | 1970-03-20 |
| FI43439C (fi) | 1971-04-13 |
| BE662271A (enrdf_load_stackoverflow) | 1965-10-08 |
| CH469664A (de) | 1969-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL142402B (nl) | Werkwijze voor het bereiden van verbindingen met de cholesterolspiegel verlagende eigenschappen. | |
| GB845649A (en) | 6-deoxytetracycline and 6-deoxyoxytetracycline | |
| GB1076937A (en) | ª-arylsulphonylethyl thiosulphuric acids, their metal salts and process for preparing them | |
| GB630712A (en) | Process of preparing intermediates useful in the preparation of penicill amine | |
| GB757137A (en) | New adrenochrome derivative and process for its production | |
| ES364711A1 (es) | Procedimiento para la preparacion de nuevos derivados de sulfanilamida. | |
| GB667199A (en) | Process for stabilizing photographic emulsions | |
| GB1104323A (en) | 3-phenylpyrrole derivatives and process for preparing the same | |
| GB638513A (en) | Process of preparing penicillamine and its derivatives | |
| GB1055060A (en) | Process for producing alpha hydroxy-glutaronitrile and its alkyl-substitute derivatives | |
| GB1119061A (en) | A process for the production of ª‡,ª‡'-tetrasubstituted ª‡-mononitrile-ª‡'-monocarboxylic acid dimethyl ethers | |
| GB914503A (en) | Aromatic compounds and methods for their production | |
| ES382620A1 (es) | Procedimiento para la preparacion de un nuevo derivado de tiepina. | |
| GB937378A (en) | Production of phenylethylbenzoic acid compounds | |
| GB1364088A (en) | 3-substituted-thio-methyl-3-cephem-4-carboxylic acid derivatives and preparation thereof | |
| GB982207A (en) | Process for the production of quinazolone derivatives | |
| GB872311A (en) | A process for the manufacture of di-imidazole derivatives | |
| ES364703A1 (es) | Procedimiento para la preparacion de nuevos derivados de sulfanilamida. | |
| ES373930A1 (es) | Procedimiento para la preparacion de nuevos derivados de a-zepina. | |
| ES383107A1 (es) | Procedimiento para la preparacion de nuevos derivados de dibenzociclopropapentaleno. | |
| GB692953A (en) | Organo-mercury compounds | |
| GB613489A (en) | Improvements in process and culture medium for the production of penicillin | |
| ES397708A1 (es) | Procedimiento para la obtencion de derivados de imidazoli- dinona. | |
| ES363847A1 (es) | Procedimiento para la preparacion de nuevos derivados de tiepina. | |
| GB826360A (en) | Retrocortin esters and their preparation |