NL1024779C2 - Gecombineerde toediening van een indolinon met een chemotherapeutisch middel voor celproliferatiestoornissen. - Google Patents

Info

Publication number

NL1024779C2

NL1024779C2 NL1024779A NL1024779A NL1024779C2 NL 1024779 C2 NL1024779 C2 NL 1024779C2 NL 1024779 A NL1024779 A NL 1024779A NL 1024779 A NL1024779 A NL 1024779A NL 1024779 C2 NL1024779 C2 NL 1024779C2

Authority

NL

Netherlands

Prior art keywords

group

compound

chemotherapeutic agent

cancer

dimethyl

Prior art date

2002-11-15

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• 239000002246 antineoplastic agent Substances 0.000 title claims description 147
• 229940127089 cytotoxic agent Drugs 0.000 title claims description 145
• JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title description 7
• 208000035269 cancer or benign tumor Diseases 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 192
• 206010028980 Neoplasm Diseases 0.000 claims description 135
• 125000000217 alkyl group Chemical group 0.000 claims description 131
• -1 mono-substituted amino group Chemical group 0.000 claims description 108
• 239000000203 mixture Substances 0.000 claims description 88
• 201000011510 cancer Diseases 0.000 claims description 77
• 125000003118 aryl group Chemical group 0.000 claims description 70
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 62
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 62
• 238000000034 method Methods 0.000 claims description 62
• 125000003545 alkoxy group Chemical group 0.000 claims description 61
• 125000001072 heteroaryl group Chemical group 0.000 claims description 59
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 57
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 56
• 150000003839 salts Chemical class 0.000 claims description 52
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• 125000005843 halogen group Chemical group 0.000 claims description 43
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• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 33
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• YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 31
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• 229910052799 carbon Inorganic materials 0.000 claims description 20
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