NL1005445C2 - Werkwijze voor het vermenigvuldigen van haar. - Google Patents
Werkwijze voor het vermenigvuldigen van haar. Download PDFInfo
- Publication number
- NL1005445C2 NL1005445C2 NL1005445A NL1005445A NL1005445C2 NL 1005445 C2 NL1005445 C2 NL 1005445C2 NL 1005445 A NL1005445 A NL 1005445A NL 1005445 A NL1005445 A NL 1005445A NL 1005445 C2 NL1005445 C2 NL 1005445C2
- Authority
- NL
- Netherlands
- Prior art keywords
- cells
- cultured
- hair
- medium
- autologous
- Prior art date
Links
- 210000004209 hair Anatomy 0.000 title claims abstract description 83
- 238000000034 method Methods 0.000 title claims abstract description 51
- 210000000442 hair follicle cell Anatomy 0.000 claims abstract description 59
- 210000003630 histaminocyte Anatomy 0.000 claims abstract description 53
- 239000002609 medium Substances 0.000 claims abstract description 40
- 230000003698 anagen phase Effects 0.000 claims abstract description 35
- 239000001963 growth medium Substances 0.000 claims abstract description 21
- 239000000284 extract Substances 0.000 claims abstract description 18
- 210000002510 keratinocyte Anatomy 0.000 claims abstract description 13
- 238000012258 culturing Methods 0.000 claims abstract description 4
- 210000004027 cell Anatomy 0.000 claims description 71
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 32
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 32
- 230000012010 growth Effects 0.000 claims description 26
- 239000000021 stimulant Substances 0.000 claims description 15
- 239000011148 porous material Substances 0.000 claims description 14
- 239000000725 suspension Substances 0.000 claims description 10
- 239000003102 growth factor Substances 0.000 claims description 9
- 210000003780 hair follicle Anatomy 0.000 claims description 8
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 5
- 239000001110 calcium chloride Substances 0.000 claims description 5
- 235000011148 calcium chloride Nutrition 0.000 claims description 5
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 5
- 239000002243 precursor Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 239000013589 supplement Substances 0.000 claims description 4
- 229920002055 compound 48/80 Polymers 0.000 claims description 3
- 230000003112 degranulating effect Effects 0.000 claims description 2
- -1 for example Chemical class 0.000 claims description 2
- 230000003252 repetitive effect Effects 0.000 claims description 2
- 238000007792 addition Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000009469 supplementation Effects 0.000 claims 1
- 238000002513 implantation Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 7
- 201000004384 Alopecia Diseases 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000003779 hair growth Effects 0.000 description 5
- 210000004748 cultured cell Anatomy 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 4
- 230000003676 hair loss Effects 0.000 description 4
- 230000003778 catagen phase Effects 0.000 description 3
- 210000001339 epidermal cell Anatomy 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000003797 telogen phase Effects 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101500025419 Homo sapiens Epidermal growth factor Proteins 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- 201000002996 androgenic alopecia Diseases 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000003636 conditioned culture medium Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940116978 human epidermal growth factor Drugs 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 210000003625 skull Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 description 1
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102400000967 Bradykinin Human genes 0.000 description 1
- 101800004538 Bradykinin Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 235000019454 L-leucine Nutrition 0.000 description 1
- 239000004395 L-leucine Substances 0.000 description 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 206010033546 Pallor Diseases 0.000 description 1
- 101710178747 Phosphatidate cytidylyltransferase 1 Proteins 0.000 description 1
- 102100031075 Serine/threonine-protein kinase Chk2 Human genes 0.000 description 1
- 102400000096 Substance P Human genes 0.000 description 1
- 101800003906 Substance P Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000003659 bee venom Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 230000003660 hair regeneration Effects 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 229940127560 insulin pen Drugs 0.000 description 1
- 239000002555 ionophore Substances 0.000 description 1
- 230000000236 ionophoric effect Effects 0.000 description 1
- 229960003136 leucine Drugs 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 229940054441 o-phthalaldehyde Drugs 0.000 description 1
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 239000012858 resilient material Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/985—Skin or skin outgrowth, e.g. hair, nails
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Eye Examination Apparatus (AREA)
- Farming Of Fish And Shellfish (AREA)
- Massaging Devices (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Indexing, Searching, Synchronizing, And The Amount Of Synchronization Travel Of Record Carriers (AREA)
- Toys (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Prostheses (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Priority Applications (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1005445A NL1005445C2 (nl) | 1997-03-05 | 1997-03-05 | Werkwijze voor het vermenigvuldigen van haar. |
| CN98804712A CN1254277A (zh) | 1997-03-05 | 1998-03-05 | 毛发增殖的方法 |
| EP98908329A EP0971679B1 (en) | 1997-03-05 | 1998-03-05 | Method for the propagation of hair |
| AU66388/98A AU732729B2 (en) | 1997-03-05 | 1998-03-05 | Method for the propagation of hair |
| IDW990962A ID22700A (id) | 1997-03-05 | 1998-03-05 | Metode pertumbuhan rambut |
| JP53894298A JP2001526560A (ja) | 1997-03-05 | 1998-03-05 | 養毛方法 |
| PL98335723A PL335723A1 (en) | 1997-03-05 | 1998-03-05 | Hair breeding method |
| CZ0313499A CZ298118B6 (cs) | 1997-03-05 | 1998-03-05 | Zpusob kosmetické reprodukce vlasu a pouzití vlasových folikulových bunek |
| IL13174098A IL131740A (en) | 1997-03-05 | 1998-03-05 | Method for the propagation of hair |
| ES98908329T ES2176977T3 (es) | 1997-03-05 | 1998-03-05 | Metodo para la propagacion de pelo. |
| PCT/NL1998/000129 WO1998047471A1 (en) | 1997-03-05 | 1998-03-05 | Method for the propagation of hair |
| DE69806232T DE69806232T2 (de) | 1997-03-05 | 1998-03-05 | Verfahren zur vermehrung von haaren |
| TR1999/02184T TR199902184T2 (xx) | 1997-03-05 | 1998-03-05 | Sa� nakli y�ntemi |
| HK00104345.4A HK1025052B (en) | 1997-03-05 | 1998-03-05 | Method for the propagation of hair |
| AT98908329T ATE219654T1 (de) | 1997-03-05 | 1998-03-05 | Verfahren zur vermehrung von haaren |
| PT98908329T PT971679E (pt) | 1997-03-05 | 1998-03-05 | Metodo de reproducao de cabelo |
| DK98908329T DK0971679T3 (da) | 1997-03-05 | 1998-03-05 | Fremgangsmåde til opformering af hår |
| CA002283172A CA2283172A1 (en) | 1997-03-05 | 1998-03-05 | Method for the propagation of hair |
| US09/380,580 US6399057B1 (en) | 1997-03-05 | 1998-03-05 | Method for the propagation of hair |
| BR9808190-0A BR9808190A (pt) | 1997-03-05 | 1998-03-05 | Processo para a reprodução de cabelos e para cultivar células do folìculo piloso de cabelos na fase anágena, meio para cultivar células do folìculo de cabelos na fase anágena, e, processo para a preparação do mesmo |
| NZ337640A NZ337640A (en) | 1997-03-05 | 1998-03-05 | Method for reproducing hair follicle cells from anagenetic hairs in the anagen phase |
| EA199900799A EA199900799A1 (ru) | 1997-03-05 | 1998-03-05 | Способ восстановления волос |
| NO19994311A NO312805B1 (no) | 1997-03-05 | 1999-09-06 | Fremgangsmåte for hårspredning |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1005445 | 1997-03-05 | ||
| NL1005445A NL1005445C2 (nl) | 1997-03-05 | 1997-03-05 | Werkwijze voor het vermenigvuldigen van haar. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL1005445C2 true NL1005445C2 (nl) | 1998-09-21 |
Family
ID=19764538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL1005445A NL1005445C2 (nl) | 1997-03-05 | 1997-03-05 | Werkwijze voor het vermenigvuldigen van haar. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6399057B1 (https=) |
| EP (1) | EP0971679B1 (https=) |
| JP (1) | JP2001526560A (https=) |
| CN (1) | CN1254277A (https=) |
| AT (1) | ATE219654T1 (https=) |
| AU (1) | AU732729B2 (https=) |
| BR (1) | BR9808190A (https=) |
| CA (1) | CA2283172A1 (https=) |
| CZ (1) | CZ298118B6 (https=) |
| DE (1) | DE69806232T2 (https=) |
| DK (1) | DK0971679T3 (https=) |
| EA (1) | EA199900799A1 (https=) |
| ES (1) | ES2176977T3 (https=) |
| ID (1) | ID22700A (https=) |
| IL (1) | IL131740A (https=) |
| NL (1) | NL1005445C2 (https=) |
| NO (1) | NO312805B1 (https=) |
| NZ (1) | NZ337640A (https=) |
| PL (1) | PL335723A1 (https=) |
| PT (1) | PT971679E (https=) |
| TR (1) | TR199902184T2 (https=) |
| WO (1) | WO1998047471A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2390053A1 (en) * | 1999-11-05 | 2001-05-10 | Gerigene Medical Corporation | Augmentation and repair of age-related soft tissue defects |
| KR20020005331A (ko) * | 2000-07-10 | 2002-01-17 | 정상훈 | 모낭 세포의 배양 방법 및 모발 이식용 키트 |
| EP1309361A1 (en) | 2000-08-08 | 2003-05-14 | Bioamide, Inc. | Scaffolds for tissue engineered hair |
| KR100371274B1 (ko) * | 2000-08-09 | 2003-02-06 | 정상훈 | 모발 이식용 키트 |
| US20030161815A1 (en) * | 2002-02-12 | 2003-08-28 | Intercytex Limited | Cell delivery system |
| CA2958146C (en) * | 2002-11-14 | 2019-08-20 | Aderans Research Institute, Inc. | Cultivation of hair inductive cells |
| US7597885B2 (en) | 2004-03-26 | 2009-10-06 | Aderans Research Institute, Inc. | Tissue engineered biomimetic hair follicle graft |
| EP1781337A4 (en) * | 2004-08-05 | 2010-06-23 | Univ Leland Stanford Junior | METHOD AND COMPOSITIONS FOR CELL ACTIVATION |
| US20060073117A1 (en) * | 2004-10-01 | 2006-04-06 | Stowers Institute For Medical Research | Methods and compositions for controlling hair follicle stem cell fate |
| KR100616752B1 (ko) * | 2004-11-29 | 2006-08-31 | 박정극 | 모낭 유도 능력이 있는 모유두 조직의 제조방법 |
| NL1030484C1 (nl) * | 2005-11-22 | 2007-05-23 | Hair Science Inst | Werkwijze voor in vivo haarvermenigvuldiging. |
| US20070148138A1 (en) | 2005-11-22 | 2007-06-28 | Aderans Research Institute, Inc. | Hair follicle graft from tissue engineered skin |
| EP1986731A4 (en) | 2006-02-09 | 2012-11-07 | Aderans Res Inst Inc | APPARATUS AND METHODS FOR DELIVERING FLUID AND MATERIAL TO A SUBJECT |
| JP5386180B2 (ja) | 2006-02-28 | 2014-01-15 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | 真皮細胞のコンパクト凝集のための方法 |
| GB0605450D0 (en) | 2006-03-17 | 2006-04-26 | Intercytex Ltd | Cell co-culture |
| KR100771171B1 (ko) * | 2006-07-05 | 2007-10-29 | 재단법인서울대학교산학협력재단 | 모낭 줄기세포의 분리, 증식 및 분화 방법 및 대머리치료용 조성물 |
| EP1964519B1 (en) | 2007-03-01 | 2009-09-02 | Sony Corporation | Method for extracting a biosubstance from hair and hair sampling device useful in the method |
| WO2009037474A1 (en) * | 2007-09-21 | 2009-03-26 | Intercytex Limited | Epidermal stimulation to enhance hair follicle formation |
| JP5775212B2 (ja) * | 2011-04-26 | 2015-09-09 | ヤング リー，ヒー | 毛髪移植素材 |
| NL2009971C2 (en) | 2012-12-12 | 2014-06-16 | Hair Science Inst | Method for in vivo hair multiplication. |
| NL2010222C2 (en) | 2013-02-01 | 2014-08-04 | Conradus Ghosal Gho | Composition and method for generating a desired cell type and/or tissue type from hair follicular stem cells. |
| NL2010225C2 (en) * | 2013-02-01 | 2014-08-04 | Conradus Ghosal Gho | Composition and method for preserving, transporting and storing living biological materials. |
| GB201816902D0 (en) * | 2018-10-17 | 2018-11-28 | Hairclone Ltd | Hair Rejuvenation |
| CN112245454A (zh) * | 2020-10-16 | 2021-01-22 | 潍坊卡多娜生物科技有限公司 | 一种细胞疤痕修复方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0236014A1 (en) * | 1986-02-21 | 1987-09-09 | University of Dundee | Stimulation of hair growth |
| WO1992007877A1 (en) * | 1990-10-31 | 1992-05-14 | The Procter & Gamble Company | Hair growth regulating composition comprising epithelium cell supernatant-derived growth factor |
| WO1995001423A1 (en) * | 1993-07-01 | 1995-01-12 | The Trustees Of The University Of Pennsylvania | Methods of culturing and modulating the growth of hair follicular stem cells |
| EP0682107A2 (en) * | 1994-04-11 | 1995-11-15 | Research Development Corporation Of Japan | Method for the long term culturing of dermal papilla cells |
| WO1996032961A1 (en) * | 1995-04-20 | 1996-10-24 | The Trustees Of The University Of Pennsylvania | Compositions and methods for regulating hair growth |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635387A (en) * | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| AU8196891A (en) * | 1990-06-25 | 1992-01-23 | Immunex Corporation | Mast cell growth factor |
| FR2707876B1 (fr) * | 1993-07-23 | 1995-09-08 | Oreal | Compositions cosmétiques pour le maintien de la coiffure présentant un pouvoir fixant amélioré. |
| TW382595B (en) * | 1993-10-15 | 2000-02-21 | Merck & Co Inc | Pharmaceutical composition for use in arresting and reversing androgenic alopecia |
| US6050990A (en) * | 1996-12-05 | 2000-04-18 | Thermolase Corporation | Methods and devices for inhibiting hair growth and related skin treatments |
-
1997
- 1997-03-05 NL NL1005445A patent/NL1005445C2/nl not_active IP Right Cessation
-
1998
- 1998-03-05 AT AT98908329T patent/ATE219654T1/de not_active IP Right Cessation
- 1998-03-05 PT PT98908329T patent/PT971679E/pt unknown
- 1998-03-05 BR BR9808190-0A patent/BR9808190A/pt not_active IP Right Cessation
- 1998-03-05 ES ES98908329T patent/ES2176977T3/es not_active Expired - Lifetime
- 1998-03-05 US US09/380,580 patent/US6399057B1/en not_active Expired - Lifetime
- 1998-03-05 WO PCT/NL1998/000129 patent/WO1998047471A1/en not_active Ceased
- 1998-03-05 IL IL13174098A patent/IL131740A/xx not_active IP Right Cessation
- 1998-03-05 TR TR1999/02184T patent/TR199902184T2/xx unknown
- 1998-03-05 EA EA199900799A patent/EA199900799A1/ru unknown
- 1998-03-05 AU AU66388/98A patent/AU732729B2/en not_active Ceased
- 1998-03-05 NZ NZ337640A patent/NZ337640A/en unknown
- 1998-03-05 EP EP98908329A patent/EP0971679B1/en not_active Expired - Lifetime
- 1998-03-05 CN CN98804712A patent/CN1254277A/zh active Pending
- 1998-03-05 CZ CZ0313499A patent/CZ298118B6/cs not_active IP Right Cessation
- 1998-03-05 ID IDW990962A patent/ID22700A/id unknown
- 1998-03-05 DE DE69806232T patent/DE69806232T2/de not_active Expired - Fee Related
- 1998-03-05 JP JP53894298A patent/JP2001526560A/ja not_active Ceased
- 1998-03-05 PL PL98335723A patent/PL335723A1/xx not_active Application Discontinuation
- 1998-03-05 CA CA002283172A patent/CA2283172A1/en not_active Abandoned
- 1998-03-05 DK DK98908329T patent/DK0971679T3/da active
-
1999
- 1999-09-06 NO NO19994311A patent/NO312805B1/no unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0236014A1 (en) * | 1986-02-21 | 1987-09-09 | University of Dundee | Stimulation of hair growth |
| WO1992007877A1 (en) * | 1990-10-31 | 1992-05-14 | The Procter & Gamble Company | Hair growth regulating composition comprising epithelium cell supernatant-derived growth factor |
| WO1995001423A1 (en) * | 1993-07-01 | 1995-01-12 | The Trustees Of The University Of Pennsylvania | Methods of culturing and modulating the growth of hair follicular stem cells |
| EP0682107A2 (en) * | 1994-04-11 | 1995-11-15 | Research Development Corporation Of Japan | Method for the long term culturing of dermal papilla cells |
| WO1996032961A1 (en) * | 1995-04-20 | 1996-10-24 | The Trustees Of The University Of Pennsylvania | Compositions and methods for regulating hair growth |
Also Published As
| Publication number | Publication date |
|---|---|
| NO312805B1 (no) | 2002-07-08 |
| EP0971679A1 (en) | 2000-01-19 |
| CZ313499A3 (cs) | 2000-02-16 |
| NZ337640A (en) | 2001-02-23 |
| ID22700A (id) | 1999-12-09 |
| ATE219654T1 (de) | 2002-07-15 |
| IL131740A0 (en) | 2001-03-19 |
| WO1998047471A1 (en) | 1998-10-29 |
| ES2176977T3 (es) | 2002-12-01 |
| PT971679E (pt) | 2002-11-29 |
| EA199900799A1 (ru) | 2000-02-28 |
| BR9808190A (pt) | 2000-05-16 |
| EP0971679B1 (en) | 2002-06-26 |
| NO994311D0 (no) | 1999-09-06 |
| CN1254277A (zh) | 2000-05-24 |
| NO994311L (no) | 1999-11-03 |
| JP2001526560A (ja) | 2001-12-18 |
| DE69806232T2 (de) | 2003-02-06 |
| US6399057B1 (en) | 2002-06-04 |
| CZ298118B6 (cs) | 2007-06-27 |
| DE69806232D1 (de) | 2002-08-01 |
| AU6638898A (en) | 1998-11-13 |
| CA2283172A1 (en) | 1998-10-29 |
| IL131740A (en) | 2003-12-10 |
| AU732729B2 (en) | 2001-04-26 |
| PL335723A1 (en) | 2000-05-08 |
| DK0971679T3 (da) | 2002-07-22 |
| TR199902184T2 (xx) | 1999-12-21 |
| HK1025052A1 (en) | 2000-11-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL1005445C2 (nl) | Werkwijze voor het vermenigvuldigen van haar. | |
| KR101854490B1 (ko) | 모색이 제어된 이식용 재생 모낭 원기의 제조방법, 당해 이식용 재생 모낭 원기를 포함하는 조성물 및 그의 이식방법 | |
| US20030161815A1 (en) | Cell delivery system | |
| KR102426746B1 (ko) | 모낭 줄기 세포의 3d 오가노이드 시스템을 이용하여 모발을 재생시키기 위한 방법 및 시스템 | |
| EP3473705A1 (en) | Method for producing artificial skin having hair follicles, sebaceous glands, and pores | |
| US20110321180A1 (en) | Compositions and methods to generate pilosebaceous units | |
| CN108236614A (zh) | 用于促进生发的生物移植用移植物 | |
| KR100616752B1 (ko) | 모낭 유도 능력이 있는 모유두 조직의 제조방법 | |
| JP4324988B2 (ja) | 発毛誘導剤および発毛方法 | |
| Messenger | Isolation, culture and in vitro behavior of cells isolated from papillae of human hair follicles | |
| Detmar et al. | Culture of hair matrix and follicular keratinocytes | |
| Teumer et al. | Follicular cell implantation: an emerging cell therapy for hair loss | |
| Harada et al. | Microdissection and isolation of mouse dental epithelial cells of continuously growing mouse incisors | |
| JP4212280B2 (ja) | ヒト毛のｉｎｖｉｖｏ発毛誘導方法と、ヒト毛を有する非ヒト動物 | |
| NL1030484C1 (nl) | Werkwijze voor in vivo haarvermenigvuldiging. | |
| MXPA99008149A (en) | Method for the propagation of hair | |
| Obara et al. | The Potential of Hair-Follicle-Associated Pluripotent (HAP) Stem Cells for Regenerative Medicine | |
| HK1025052B (en) | Method for the propagation of hair | |
| TW202305116A (zh) | 細胞培養上清液之製造方法，及化妝品之製造方法 | |
| HK40004535A (en) | Method for producing artificial skin having hair follicles, sebaceous glands, and pores | |
| Kitano et al. | In vitro keratin expression of hair cells | |
| Rehman et al. | In Vitro Culturing and Harvesting of Human Plucked Hair Follicles | |
| WO2006049336A1 (ja) | 幹細胞の調整方法と組織治療剤。 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD2B | A search report has been drawn up | ||
| VD1 | Lapsed due to non-payment of the annual fee |
Effective date: 20061001 |