NI201900075A - Compuesto moduladores del receptor de hidrocarburos de arilo (ahr) - Google Patents

Compuesto moduladores del receptor de hidrocarburos de arilo (ahr)

Info

Publication number
NI201900075A
NI201900075A NI201900075A NI201900075A NI201900075A NI 201900075 A NI201900075 A NI 201900075A NI 201900075 A NI201900075 A NI 201900075A NI 201900075 A NI201900075 A NI 201900075A NI 201900075 A NI201900075 A NI 201900075A
Authority
NI
Nicaragua
Prior art keywords
ahr
aryl hydrocarbon
hydrocarbon receptor
modulator compound
compounds
Prior art date
Application number
NI201900075A
Other languages
English (en)
Inventor
Steeneck Christoph
Deuschle Ulrich
Albers Michael
Hoffmann Thomas
Original Assignee
Phenex Pharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phenex Pharmaceuticals Ag filed Critical Phenex Pharmaceuticals Ag
Publication of NI201900075A publication Critical patent/NI201900075A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a compuestos que pueden actuar como moduladores del receptor de hidrocarburos de arilo (AhR) y, en particular, como antagonistas de AhR. La invención además se refiere al uso de los compuestos para el tratamiento y/o profilaxis de enfermedades y/o condiciones a través de la unión de dicho receptor de hidrocarburos de arilo por dichos compuestos.
NI201900075A 2017-02-01 2019-07-15 Compuesto moduladores del receptor de hidrocarburos de arilo (ahr) NI201900075A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17000157 2017-02-01

Publications (1)

Publication Number Publication Date
NI201900075A true NI201900075A (es) 2019-10-30

Family

ID=57960222

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201900075A NI201900075A (es) 2017-02-01 2019-07-15 Compuesto moduladores del receptor de hidrocarburos de arilo (ahr)

Country Status (25)

Country Link
US (1) US11376241B2 (es)
EP (1) EP3577115B1 (es)
JP (1) JP2020505467A (es)
KR (1) KR20190113902A (es)
CN (1) CN110234650A (es)
AR (1) AR110790A1 (es)
AU (1) AU2018216955B2 (es)
BR (1) BR112019015704A2 (es)
CA (1) CA3051034A1 (es)
CL (1) CL2019002112A1 (es)
CO (1) CO2019007882A2 (es)
CR (1) CR20190393A (es)
CU (1) CU20190067A7 (es)
EA (1) EA201991600A1 (es)
EC (1) ECSP19055179A (es)
IL (1) IL268082A (es)
MX (1) MX2019008993A (es)
NI (1) NI201900075A (es)
PE (1) PE20191479A1 (es)
PH (1) PH12019550136A1 (es)
SG (1) SG11201906959RA (es)
TW (1) TWI674260B (es)
UA (1) UA122746C2 (es)
UY (1) UY37590A (es)
WO (1) WO2018141855A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI674260B (zh) 2017-02-01 2019-10-11 德商菲尼克斯製藥股份有限公司 芳基烴受體(AhR)調節劑化合物
TWI752155B (zh) 2017-02-01 2022-01-11 德商菲尼克斯製藥股份有限公司 芳香烴受體(AhR)調節劑化合物
EP3749669B1 (en) 2018-02-06 2023-03-08 Ideaya Biosciences, Inc. Ahr modulators
WO2020021024A1 (en) * 2018-07-26 2020-01-30 Phenex Pharmaceuticals Ag Substituted bicyclic compounds as modulators of the aryl hydrocarbon receptor (ahr)
CN109813913B (zh) * 2019-01-31 2021-11-09 中国医学科学院肿瘤医院 芳烃受体(AhR)在预测免疫治疗效果中的应用
US20220281824A1 (en) * 2019-07-30 2022-09-08 Oregon State University Aryl hydrocarbon receptor activators
KR102351515B1 (ko) 2019-12-17 2022-01-14 (주)수파드엘릭사 아릴 탄화수소 수용체의 활성을 억제하는 폡타이드 및 이를 이용하는 화장료 조성물
WO2021148628A1 (en) * 2020-01-23 2021-07-29 Phenex Pharmaceuticals Ag Oxalamide substituted heterocyclic compounds as modulators of the aryl hydrocarbon receptor (ahr)
CN114181212B (zh) * 2020-09-15 2023-06-06 山东轩竹医药科技有限公司 哒嗪酮类AhR抑制剂
EP4267131A1 (en) * 2020-12-28 2023-11-01 Celgene Corporation Heterocyclic compounds and their use for parasitic diseases

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PT948495E (pt) 1996-11-19 2004-08-31 Amgen Inc Agentes anti-inflamatorios de pirrolo fundido substituidos em arilo e heteroarilo
AU2003270426A1 (en) 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
US20050032869A1 (en) 2003-07-08 2005-02-10 Pharmacia Italia S.P.A. Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
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US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
PL2488486T3 (pl) 2009-10-13 2020-01-31 Ligand Pharmaceuticals Inc. Małocząsteczkowe związki mimetyczne hematopoetycznego czynnika wzrostu i ich zastosowania
EP3689347A1 (en) * 2009-11-02 2020-08-05 Ariagen, Inc. Ite for cancer intervention and eradication
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PL2531501T3 (pl) 2010-02-03 2014-05-30 Takeda Pharmaceuticals Co Inhibitory kinazy 1 regulującej sygnał apoptotyczny
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TWI510487B (zh) 2010-04-21 2015-12-01 Plexxikon Inc 用於激酶調節的化合物和方法及其適應症
CN107648216B (zh) 2010-07-27 2021-03-30 波士顿大学管理委员会 作为新型癌症疗法的芳烃受体(AhR)调节剂
GB201104267D0 (en) * 2011-03-14 2011-04-27 Cancer Rec Tech Ltd Pyrrolopyridineamino derivatives
CN104755461A (zh) 2012-10-17 2015-07-01 霍夫曼-拉罗奇有限公司 作为trp通道拮抗剂的6-氨基吲哚衍生物
HUE036739T2 (hu) 2012-12-21 2018-07-30 Plexxikon Inc Vegyületek és eljárások kináz modulációra, és azok indikációi
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TWI752155B (zh) * 2017-02-01 2022-01-11 德商菲尼克斯製藥股份有限公司 芳香烴受體(AhR)調節劑化合物
TW201835070A (zh) 2017-02-21 2018-10-01 德商菲尼克斯製藥股份有限公司 芳香烴受體(AhR)調節劑化合物

Also Published As

Publication number Publication date
US20210260045A1 (en) 2021-08-26
EA201991600A1 (ru) 2020-03-10
WO2018141855A1 (en) 2018-08-09
CU20190067A7 (es) 2020-03-04
CA3051034A1 (en) 2018-08-09
EP3577115A1 (en) 2019-12-11
IL268082A (en) 2019-09-26
CL2019002112A1 (es) 2019-12-20
SG11201906959RA (en) 2019-08-27
CO2019007882A2 (es) 2019-10-09
EP3577115B1 (en) 2020-12-02
BR112019015704A2 (pt) 2020-04-07
AU2018216955B2 (en) 2020-09-17
AR110790A1 (es) 2019-05-02
UA122746C2 (uk) 2020-12-28
MX2019008993A (es) 2019-12-19
TWI674260B (zh) 2019-10-11
US11376241B2 (en) 2022-07-05
PE20191479A1 (es) 2019-10-16
PH12019550136A1 (en) 2020-03-02
UY37590A (es) 2018-02-28
CN110234650A (zh) 2019-09-13
TW201838991A (zh) 2018-11-01
KR20190113902A (ko) 2019-10-08
JP2020505467A (ja) 2020-02-20
AU2018216955A1 (en) 2019-08-01
CR20190393A (es) 2019-10-21
ECSP19055179A (es) 2019-08-30

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