NI201800063A - Compuesto de 1,3,4-tiadiazol y su uso en el tratamiento del cáncer - Google Patents

Compuesto de 1,3,4-tiadiazol y su uso en el tratamiento del cáncer

Info

Publication number
NI201800063A
NI201800063A NI201800063A NI201800063A NI201800063A NI 201800063 A NI201800063 A NI 201800063A NI 201800063 A NI201800063 A NI 201800063A NI 201800063 A NI201800063 A NI 201800063A NI 201800063 A NI201800063 A NI 201800063A
Authority
NI
Nicaragua
Prior art keywords
compound
thadiazole
cancer
treatment
formula
Prior art date
Application number
NI201800063A
Other languages
English (en)
Spanish (es)
Inventor
Raymond Verschoyle Finlay Maurice
Robert Perkins David
Wilhelmus Maria Nissink Johannes
Antoni Raubo Piotr
Duncan Smith Peter
Bailey Andrew
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NI201800063A publication Critical patent/NI201800063A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
NI201800063A 2015-11-30 2018-05-29 Compuesto de 1,3,4-tiadiazol y su uso en el tratamiento del cáncer NI201800063A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562260784P 2015-11-30 2015-11-30

Publications (1)

Publication Number Publication Date
NI201800063A true NI201800063A (es) 2018-10-18

Family

ID=57460503

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201800063A NI201800063A (es) 2015-11-30 2018-05-29 Compuesto de 1,3,4-tiadiazol y su uso en el tratamiento del cáncer

Country Status (28)

Country Link
US (1) US10040789B2 (enExample)
EP (1) EP3383872B1 (enExample)
JP (1) JP6821680B2 (enExample)
KR (1) KR20180083411A (enExample)
CN (1) CN108349965B (enExample)
AR (1) AR106875A1 (enExample)
AU (1) AU2016361834B2 (enExample)
BR (1) BR112018008330B1 (enExample)
CA (1) CA3005517C (enExample)
CL (1) CL2018001409A1 (enExample)
CO (1) CO2018006930A2 (enExample)
DK (1) DK3383872T3 (enExample)
DO (1) DOP2018000135A (enExample)
EA (1) EA035519B9 (enExample)
ES (1) ES2796562T3 (enExample)
IL (1) IL259508A (enExample)
MX (1) MX2018006483A (enExample)
MY (1) MY195680A (enExample)
NI (1) NI201800063A (enExample)
NZ (1) NZ743699A (enExample)
PE (1) PE20181522A1 (enExample)
PH (1) PH12018501133A1 (enExample)
SG (1) SG11201803808VA (enExample)
SV (1) SV2018005700A (enExample)
TN (1) TN2018000118A1 (enExample)
TW (1) TW201731511A (enExample)
WO (1) WO2017093301A1 (enExample)
ZA (1) ZA201804361B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201520959D0 (en) 2015-11-27 2016-01-13 Astrazeneca Ab And Cancer Res Technology Ltd Bis-pyridazine compounds and their use in treating cancer
US9938265B2 (en) 2015-11-30 2018-04-10 Astrazeneca Ab 1,3,4-thiadiazole compounds and their use in treating cancer
US10323028B2 (en) 2015-11-30 2019-06-18 Astrazeneca Ab 1,3,4-thiadiazole compounds and their use in treating cancer
CN112888686B (zh) * 2018-10-16 2022-04-19 南京明德新药研发有限公司 噻二唑衍生物及其作为gls1抑制剂的应用
CN114560855B (zh) * 2021-03-26 2023-05-23 成都苑东生物制药股份有限公司 环烷基甲酰胺类衍生物、其制备方法及用途
WO2025196446A1 (en) 2024-03-22 2025-09-25 Sitryx Therapeutics Limited Thiadiazoles as glutaminase 1 inhibitors
WO2025196447A1 (en) 2024-03-22 2025-09-25 Sitryx Therapeutics Limited Thiadiazoles as glutaminase 1 inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS59705B1 (sr) 2011-11-21 2020-01-31 Calithera Biosciences Inc Heterociklični inhibitori glutaminaze
US9029531B2 (en) 2012-11-22 2015-05-12 Agios Pharmaceuticals, Inc. Compounds and their methods of use
WO2014079011A1 (en) * 2012-11-22 2014-05-30 Agios Pharmaceuticals, Inc. Heterocyclic compounds for inhibiting glutaminase and their methods of use
EP3092235A2 (en) 2014-01-06 2016-11-16 Rhizen Pharmaceuticals S.A. Novel inhibitors of glutaminase
GB201409624D0 (en) * 2014-05-30 2014-07-16 Astrazeneca Ab 1,3,4-thiadiazole compounds and their use in treating cancer
US9938265B2 (en) * 2015-11-30 2018-04-10 Astrazeneca Ab 1,3,4-thiadiazole compounds and their use in treating cancer
US10323028B2 (en) * 2015-11-30 2019-06-18 Astrazeneca Ab 1,3,4-thiadiazole compounds and their use in treating cancer

Also Published As

Publication number Publication date
EA035519B1 (ru) 2020-06-29
EA201891239A1 (ru) 2018-11-30
EA035519B9 (ru) 2020-08-10
CA3005517C (en) 2023-12-12
US20170333429A1 (en) 2017-11-23
AR106875A1 (es) 2018-02-28
WO2017093301A1 (en) 2017-06-08
JP2018535235A (ja) 2018-11-29
CL2018001409A1 (es) 2018-12-07
AU2016361834B2 (en) 2019-11-14
MY195680A (en) 2023-02-03
SG11201803808VA (en) 2018-06-28
CN108349965A (zh) 2018-07-31
DK3383872T3 (da) 2020-06-08
CA3005517A1 (en) 2017-06-08
DOP2018000135A (es) 2018-06-30
PE20181522A1 (es) 2018-09-24
US10040789B2 (en) 2018-08-07
EP3383872B1 (en) 2020-05-20
EP3383872A1 (en) 2018-10-10
KR20180083411A (ko) 2018-07-20
TW201731511A (zh) 2017-09-16
AU2016361834A1 (en) 2018-07-12
TN2018000118A1 (en) 2019-10-04
BR112018008330B1 (pt) 2023-03-07
CO2018006930A2 (es) 2018-10-10
PH12018501133A1 (en) 2019-01-21
ES2796562T3 (es) 2020-11-27
JP6821680B2 (ja) 2021-01-27
MX2018006483A (es) 2019-08-12
CN108349965B (zh) 2021-10-26
IL259508A (en) 2018-07-31
SV2018005700A (es) 2019-03-07
ZA201804361B (en) 2019-07-31
BR112018008330A2 (pt) 2018-10-30
NZ743699A (en) 2023-02-24

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