MY170086A - Amorphous form of an akt inhibiting pyrimidinyl - cyclopentane compound, compositions and methods thereof - Google Patents

Amorphous form of an akt inhibiting pyrimidinyl - cyclopentane compound, compositions and methods thereof

Info

Publication number
MY170086A
MY170086A MYPI2014703413A MYPI2014703413A MY170086A MY 170086 A MY170086 A MY 170086A MY PI2014703413 A MYPI2014703413 A MY PI2014703413A MY PI2014703413 A MYPI2014703413 A MY PI2014703413A MY 170086 A MY170086 A MY 170086A
Authority
MY
Malaysia
Prior art keywords
methods
compositions
amorphous form
cyclopentane compound
akt inhibiting
Prior art date
Application number
MYPI2014703413A
Other languages
English (en)
Inventor
Paroma Chakravarty
Sanjeev Kothari
Francis Gosselin
Scott J Savage
Jeffrey Stults
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48539412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY170086(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MY170086A publication Critical patent/MY170086A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
MYPI2014703413A 2012-05-17 2013-05-17 Amorphous form of an akt inhibiting pyrimidinyl - cyclopentane compound, compositions and methods thereof MY170086A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261648536P 2012-05-17 2012-05-17

Publications (1)

Publication Number Publication Date
MY170086A true MY170086A (en) 2019-07-04

Family

ID=48539412

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2014703413A MY170086A (en) 2012-05-17 2013-05-17 Amorphous form of an akt inhibiting pyrimidinyl - cyclopentane compound, compositions and methods thereof

Country Status (31)

Country Link
US (2) US9290458B2 (ja)
EP (2) EP3719014A1 (ja)
JP (2) JP6283663B2 (ja)
KR (4) KR20210095238A (ja)
CN (1) CN104470912B (ja)
AU (2) AU2013262548B2 (ja)
BR (1) BR112014028593A2 (ja)
CA (1) CA2873663C (ja)
CL (1) CL2014003115A1 (ja)
CO (1) CO7151489A2 (ja)
CR (1) CR20140560A (ja)
DK (1) DK2858989T3 (ja)
ES (1) ES2799512T3 (ja)
HK (1) HK1208462A1 (ja)
HR (1) HRP20200992T1 (ja)
HU (1) HUE051254T2 (ja)
IL (2) IL235712B (ja)
LT (1) LT2858989T (ja)
MA (1) MA37650A1 (ja)
MX (1) MX353041B (ja)
MY (1) MY170086A (ja)
NZ (1) NZ702513A (ja)
PE (1) PE20150725A1 (ja)
PH (1) PH12014502538B1 (ja)
PL (1) PL2858989T3 (ja)
PT (1) PT2858989T (ja)
RS (1) RS60417B9 (ja)
RU (1) RU2650511C2 (ja)
SG (1) SG11201407618VA (ja)
SI (1) SI2858989T1 (ja)
WO (1) WO2013173811A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6284928B2 (ja) 2012-05-17 2018-02-28 アレイ バイオファーマ、インコーポレイテッド ヒドロキシル化シクロペンチルピリミジン化合物を作製するためのプロセス
US9290458B2 (en) 2012-05-17 2016-03-22 Genentech, Inc. Amorphous form of an AKT inhibiting pyrimidinyl-cyclopentane compound, compositions and methods thereof
CN105899492B (zh) 2013-11-15 2021-08-24 豪夫迈·罗氏有限公司 用于制备嘧啶基环戊烷化合物的方法
ES2793530T3 (es) * 2014-05-19 2020-11-16 Tillotts Pharma Ag Cápsulas revestidas de liberación modificada
BR112019002007B1 (pt) * 2016-08-10 2024-01-16 F. Hoffmann-La Roche Ag Composição farmacêutica e uso de uma composição farmacêutica
EP4013419A1 (en) * 2019-08-12 2022-06-22 F. Hoffmann-La Roche AG Treatment of breast cancer using combination therapies comprising an atp competitive akt inhibitor, a cdk4/6 inhibitor, and fulvestrant
EP4351522A1 (en) * 2021-06-09 2024-04-17 Lonza Bend Inc. Mixed solvents for spray drying for preparation of amorphous solid dispersions
WO2023043869A1 (en) * 2021-09-15 2023-03-23 Teva Pharmaceuticals International Gmbh Solid state forms of ipatasertib citrate

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9408197A (pt) 1993-12-12 1997-08-26 Agrogene Ltd Método para proteger plantas contra doenças fúngicas
JP2001524079A (ja) 1997-04-07 2001-11-27 メルク エンド カンパニー インコーポレーテッド ガンの治療方法
US6201023B1 (en) 1997-06-10 2001-03-13 Agrogene Ltd. Methods and compositions to protect crops against plant parasitic nematodes
ES2137137B1 (es) 1998-05-25 2000-08-16 Medichem Sa Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica.
EP0982300A3 (en) 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications
US6376496B1 (en) 1999-03-03 2002-04-23 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
AU7715300A (en) 1999-09-27 2001-04-30 Merck & Co., Inc. Method of preventing osteoporosis
CN1309370C (zh) 2002-02-01 2007-04-11 辉瑞产品公司 使用改进的喷雾干燥设备制备均匀喷雾干燥的固体非晶形药物分散体的方法
EP1636200A2 (en) 2003-06-09 2006-03-22 Boehringer Ingelheim International GmbH Inhibitors of papilloma virus
RU2006121990A (ru) 2003-11-21 2007-12-27 Эррэй Биофарма Инк. (Us) Ингибиторы протеинкиназ акт
MY139645A (en) * 2004-02-11 2009-10-30 Amgen Inc Vanilloid receptor ligands and their use in treatments
US8927546B2 (en) 2006-02-28 2015-01-06 Dart Neuroscience (Cayman) Ltd. Therapeutic piperazines
UA95641C2 (en) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
TWI450720B (zh) 2007-07-05 2014-09-01 Array Biopharma Inc 作為ａｋｔ蛋白質激酶抑制劑之嘧啶環戊烷
US20100298289A1 (en) 2007-10-09 2010-11-25 Ucb Pharma, S.A. Heterobicyclic compounds as histamine h4-receptor antagonists
AU2009204025B2 (en) * 2008-01-09 2014-02-20 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
SG175144A1 (en) 2009-04-15 2011-11-28 Abbott Lab Anti-viral compounds
WO2011050016A1 (en) 2009-10-23 2011-04-28 Eli Lilly And Company Akt inhibitors
MX2012011887A (es) * 2010-04-16 2012-11-30 Genentech Inc Foxo 3a como biomarcador predictivo para la eficacia del inhibidor de la via de quinasa pi3k/akt.
US9050334B2 (en) 2010-07-16 2015-06-09 Innov88 Llc MIF inhibitors and their uses
WO2012177925A1 (en) 2011-06-21 2012-12-27 The Board Institute, Inc. Akt inhibitors for treating cancer expressing a magi3 - akt3 fusion gene
CN104471070B (zh) 2012-05-17 2018-09-25 基因泰克公司 制备羟基化环戊并嘧啶化合物和其盐的方法
PL2861583T3 (pl) 2012-05-17 2016-12-30 Sposób wytwarzania hydroksylowanych związków cyklopentylopirymidyny
US9290458B2 (en) 2012-05-17 2016-03-22 Genentech, Inc. Amorphous form of an AKT inhibiting pyrimidinyl-cyclopentane compound, compositions and methods thereof
ES2668477T3 (es) 2012-05-17 2018-05-18 Genentech, Inc. Proceso de preparación de compuestos de aminoácidos
JP6284928B2 (ja) 2012-05-17 2018-02-28 アレイ バイオファーマ、インコーポレイテッド ヒドロキシル化シクロペンチルピリミジン化合物を作製するためのプロセス
US20140121193A1 (en) 2012-11-01 2014-05-01 Robert S. Katz Methods for treating fibromyalgia
US20150376198A1 (en) 2013-02-18 2015-12-31 The Scripps Research Institute Modulators of vasopressin receptors with therapeutic potential
AU2014237198A1 (en) 2013-03-15 2015-11-05 Shifa Biomedical Corporation Anti-PCSK9 compounds and methods for the treatment and/or prevention of cardiovascular diseases

Also Published As

Publication number Publication date
US9290458B2 (en) 2016-03-22
JP2015517533A (ja) 2015-06-22
AU2017279607B2 (en) 2018-11-22
EP2858989B9 (en) 2021-04-14
ES2799512T3 (es) 2020-12-18
KR20210095238A (ko) 2021-07-30
PE20150725A1 (es) 2015-05-17
RS60417B9 (sr) 2021-07-30
KR20200074252A (ko) 2020-06-24
CO7151489A2 (es) 2014-12-29
HK1208462A1 (en) 2016-03-04
US9505725B2 (en) 2016-11-29
RS60417B1 (sr) 2020-07-31
JP2018062536A (ja) 2018-04-19
CN104470912B (zh) 2017-11-14
CR20140560A (es) 2015-01-12
HUE051254T2 (hu) 2021-03-01
KR20150020200A (ko) 2015-02-25
IL272037A (en) 2020-02-27
US20150274677A1 (en) 2015-10-01
IL272037B (en) 2020-10-29
LT2858989T (lt) 2020-08-10
MA37650A1 (fr) 2016-11-30
AU2013262548B2 (en) 2017-09-21
US20160152575A1 (en) 2016-06-02
SG11201407618VA (en) 2015-01-29
MX353041B (es) 2017-12-18
WO2013173811A1 (en) 2013-11-21
IL235712A0 (en) 2015-02-01
JP6283663B2 (ja) 2018-02-21
BR112014028593A2 (pt) 2017-12-19
CN104470912A (zh) 2015-03-25
HRP20200992T1 (hr) 2020-10-16
AU2013262548A1 (en) 2015-01-15
RU2014151016A (ru) 2016-07-10
CL2014003115A1 (es) 2015-07-03
EP3719014A1 (en) 2020-10-07
DK2858989T3 (da) 2020-06-02
PH12014502538A1 (en) 2015-01-21
AU2017279607A1 (en) 2018-01-18
KR20220143143A (ko) 2022-10-24
JP6518352B2 (ja) 2019-05-22
PL2858989T3 (pl) 2020-11-16
NZ702513A (en) 2016-09-30
EP2858989B1 (en) 2020-05-06
IL235712B (en) 2020-01-30
KR102125588B1 (ko) 2020-06-22
RU2650511C2 (ru) 2018-04-16
PT2858989T (pt) 2020-06-25
CA2873663A1 (en) 2013-11-21
AU2017279607C1 (en) 2019-05-16
SI2858989T1 (sl) 2020-08-31
MX2014013856A (es) 2015-02-18
EP2858989A1 (en) 2015-04-15
CA2873663C (en) 2020-01-14
PH12014502538B1 (en) 2015-01-21

Similar Documents

Publication Publication Date Title
PH12014502538A1 (en) Amorphous form of an akt inhibiting pyrimidinyl - cyclopentane compound, compositions and methods tehreof
PH12015501779A1 (en) Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus- related kinases (jak)
MX2015002511A (es) Compuestos de dihidropirimidina y su aplicacion en productos farmaceuticos.
MX2016006564A (es) Compuestos dihidropirimidina y su aplicacion en productos farmaceuticos.
MX345830B (es) Compuestos a base de pirazol[1,5-a]pirimidina, composiciones que los comprenden, y metodos para su uso.
PH12015502705B1 (en) Processes of making and crystalline forms of a mdm2 inhibitor
RS54030B1 (en) PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR CANCER TREATMENT
NZ702950A (en) Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof
GEP201706620B (en) NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS
SG10201402492TA (en) Use of jak inhibitors 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile
MX347917B (es) Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso.
MX2012014017A (es) Derivados de heteroaril imidazolona como inhibidores de jak.
MX2012009074A (es) Compuestos de urea pirrolo [2, 3-d] pirimidina como inhibidores de janus quinasa.
NZ586720A (en) Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
NZ702939A (en) Process for making amino acid compounds
MX2015013414A (es) N-(2-ciano heterociclil)pirazolo piridonas como inhibidores de janus quinasa.
WO2012030914A8 (en) 4-azolylaminoquinazoline derivatives and methods of use thereof
MX2019011513A (es) Procesos para preparar compuestos de (ciclopentil[d]pirimidin-4-il )piperazina.
IL234966A0 (en) Crystal forms of (4-(s-amino-4)-1)-n-chlorophenyl)-3-hydroxypropyl)-1-(7h-pyrrolo [3,2-d]pyrimidin-4-yl)piperidine-4-carboxamide
NZ705994A (en) Process for preparing pemetrexed di potassium and its hydrates
IN2013CH05870A (ja)