MY148483A - 4,5-diphenyl-pyrimidinyl-oxy or-mercapto substituted carboxylic acids, method for the production and use thereof as medicaments - Google Patents
4,5-diphenyl-pyrimidinyl-oxy or-mercapto substituted carboxylic acids, method for the production and use thereof as medicamentsInfo
- Publication number
- MY148483A MY148483A MYPI20084471A MYPI20084471A MY148483A MY 148483 A MY148483 A MY 148483A MY PI20084471 A MYPI20084471 A MY PI20084471A MY PI20084471 A MYPI20084471 A MY PI20084471A MY 148483 A MY148483 A MY 148483A
- Authority
- MY
- Malaysia
- Prior art keywords
- pyrimidinyl
- oxy
- diphenyl
- carboxylic acids
- medicaments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006021872A DE102006021872B4 (de) | 2006-05-11 | 2006-05-11 | 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
MY148483A true MY148483A (en) | 2013-04-30 |
Family
ID=38283003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MYPI20084471A MY148483A (en) | 2006-05-11 | 2007-04-30 | 4,5-diphenyl-pyrimidinyl-oxy or-mercapto substituted carboxylic acids, method for the production and use thereof as medicaments |
Country Status (16)
Country | Link |
---|---|
US (1) | US7709494B2 (de) |
EP (1) | EP2024339B1 (de) |
JP (1) | JP2009536626A (de) |
KR (1) | KR20090007413A (de) |
CN (1) | CN101421249A (de) |
AR (1) | AR060993A1 (de) |
AU (1) | AU2007250210B2 (de) |
BR (1) | BRPI0711399A2 (de) |
CA (1) | CA2651466A1 (de) |
DE (1) | DE102006021872B4 (de) |
IL (1) | IL195178A0 (de) |
MX (1) | MX2008014208A (de) |
MY (1) | MY148483A (de) |
NO (1) | NO20085064L (de) |
TW (1) | TW200815367A (de) |
WO (1) | WO2007131619A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7465804B2 (en) | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
EP1924546A1 (de) | 2005-09-14 | 2008-05-28 | Amgen, Inc | Konformationseingeschränkte 3- (4-hydroxy-phenyl) substitutierte propansäuren zur behandlung von stoffwechselstörungen |
AU2007292816B2 (en) | 2006-09-07 | 2011-11-17 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
EP2064193A1 (de) | 2006-09-07 | 2009-06-03 | Amgen, Inc | Heterozyklische gpr40-modulatoren |
EP2139843B1 (de) | 2007-04-16 | 2013-12-25 | Amgen, Inc | Substituierte biphenyl phenoxy-, thiophenyl- und aminophenylpropansäure als gpr40-modulatoren |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US8030354B2 (en) | 2007-10-10 | 2011-10-04 | Amgen Inc. | Substituted biphenyl GPR40 modulators |
EP2260017A1 (de) | 2008-03-06 | 2010-12-15 | Amgen, Inc | Konformationseingeschränkte carbonsäurederivate, die sich für die behandlung von stoffwechselerkrankungen eignen |
JP5551707B2 (ja) | 2008-10-15 | 2014-07-16 | アムジエン・インコーポレーテツド | スピロ環gpr40調節因子 |
US8193243B2 (en) | 2009-05-19 | 2012-06-05 | Neuroderm, Ltd. | Continuous administration of dopa decarboxylase inhibitors and compositions for same |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP3159331A1 (de) | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolone als fettsäuresynthasehemmer |
WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
US20130197043A1 (en) | 2010-08-31 | 2013-08-01 | Snu R&Db Foundation | Use of the fetal reprogramming of a ppar agonist |
CN103442693A (zh) * | 2010-11-15 | 2013-12-11 | 纽罗德姆有限公司 | L-多巴、多巴脱羧酶抑制剂、儿茶酚-o-甲基转移酶抑制剂及其组合物的连续施用 |
US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (de) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamidderivate als kinaseinhibitoren |
TR201903492T4 (tr) | 2012-06-05 | 2019-04-22 | Neuroderm Ltd | Apomorfin ve organik asitler içeren bileşimler ve bunların kullanım alanları. |
US20150297573A1 (en) | 2012-10-24 | 2015-10-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL |
EP3076959B1 (de) | 2013-12-04 | 2018-07-04 | Merck Sharp & Dohme Corp. | Antidiabetische bicyclische verbindungen |
US10059667B2 (en) | 2014-02-06 | 2018-08-28 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
ES2836325T3 (es) | 2014-03-13 | 2021-06-24 | Neuroderm Ltd | Composiciones del inhibidor de la dopa descarboxilasa |
US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
CN104193731B (zh) * | 2014-08-27 | 2017-03-15 | 广东东阳光药业有限公司 | 一种脲取代联苯类化合物及其组合物及用途 |
EP3273981B1 (de) | 2015-03-24 | 2020-04-29 | INSERM - Institut National de la Santé et de la Recherche Médicale | Verfahren und pharmazeutische zusammensetzung zur verwendung bei der behandlung von diabetes |
ES2949664T3 (es) | 2018-02-13 | 2023-10-02 | Gilead Sciences Inc | Inhibidores PD-1/PD-L1 |
KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
PT3820572T (pt) | 2018-07-13 | 2023-11-10 | Gilead Sciences Inc | Inibidores pd-1/pd-l1 |
US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2665159B1 (fr) * | 1990-07-24 | 1992-11-13 | Rhone Poulenc Sante | Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent. |
US7405221B2 (en) * | 2002-09-27 | 2008-07-29 | Merck & Co., Inc. | Substituted pyrimidines |
US20040259887A1 (en) * | 2003-06-18 | 2004-12-23 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
-
2006
- 2006-05-11 DE DE102006021872A patent/DE102006021872B4/de not_active Withdrawn - After Issue
-
2007
- 2007-04-30 WO PCT/EP2007/003803 patent/WO2007131619A1/de active Application Filing
- 2007-04-30 JP JP2009508190A patent/JP2009536626A/ja not_active Ceased
- 2007-04-30 KR KR1020087027547A patent/KR20090007413A/ko active IP Right Grant
- 2007-04-30 AU AU2007250210A patent/AU2007250210B2/en not_active Ceased
- 2007-04-30 EP EP07724730.2A patent/EP2024339B1/de not_active Not-in-force
- 2007-04-30 MX MX2008014208A patent/MX2008014208A/es active IP Right Grant
- 2007-04-30 BR BRPI0711399-4A patent/BRPI0711399A2/pt not_active IP Right Cessation
- 2007-04-30 CA CA002651466A patent/CA2651466A1/en not_active Abandoned
- 2007-04-30 CN CNA2007800133694A patent/CN101421249A/zh active Pending
- 2007-04-30 MY MYPI20084471A patent/MY148483A/en unknown
- 2007-05-09 AR ARP070102011A patent/AR060993A1/es not_active Application Discontinuation
- 2007-05-09 TW TW096116360A patent/TW200815367A/zh unknown
-
2008
- 2008-11-09 IL IL195178A patent/IL195178A0/en unknown
- 2008-11-10 US US12/267,925 patent/US7709494B2/en not_active Expired - Fee Related
- 2008-12-04 NO NO20085064A patent/NO20085064L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BRPI0711399A2 (pt) | 2011-11-01 |
WO2007131619A1 (de) | 2007-11-22 |
CA2651466A1 (en) | 2007-11-22 |
EP2024339B1 (de) | 2013-04-10 |
EP2024339A1 (de) | 2009-02-18 |
AR060993A1 (es) | 2008-07-30 |
TW200815367A (en) | 2008-04-01 |
US20090149486A1 (en) | 2009-06-11 |
NO20085064L (no) | 2009-02-06 |
AU2007250210A1 (en) | 2007-11-22 |
IL195178A0 (en) | 2009-08-03 |
KR20090007413A (ko) | 2009-01-16 |
MX2008014208A (es) | 2008-11-14 |
CN101421249A (zh) | 2009-04-29 |
US7709494B2 (en) | 2010-05-04 |
DE102006021872B4 (de) | 2008-04-17 |
JP2009536626A (ja) | 2009-10-15 |
DE102006021872A1 (de) | 2007-12-27 |
AU2007250210B2 (en) | 2011-11-10 |
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