MXPA97001218A - Composition and method for illuminating the lower parapados of the or - Google Patents

Abstract

The present invention relates to a composition and a method for the topical treatment of the skin, which comprises the use of derivatives of living yeast cells in combination with a suitable vehicle for the treatment of discoloration and intumescences in the facial skin of the eyelids bottom of the oj

Description

COMPOSITION AND METHOD FOR ILLUMINATING THE LOWER PARAPHADOS OF THE EYES FIELD OF THE INVENTION EJ prcscmc invention relates to compositions for local treatment and skin problems associated with abnormal pigmentation. More particularly, the invention comprises the use of derivatives of live ferment cells in combination with a suitable vehicle, for the treatment of discolorations and bag formations in the facial skin of the inner eyelids of the eyes. BACKGROUND OF THE RELATED ART The intumescence or formation of pockets in the lower eyelids of the associated decorating eyes has many ecological factors that include an abnormal increase in the spillage of the capillaries underneath the surface of the skin. F.l finido that < < P accumulates under the skin in the region of the lower eyelids resulting in an edema that manifests itself as the formation of pockets under the eyes, often relativizing it to 'smell more? cuio eu c? nlrasLe with the facial areas that surround the mi ma * la < Bad ones. perceived by consumers as cosmetically unacceptable. The exact reason for such an increase in capillary permeability is not cs ft.einpre oiu.J. ¡Au diveisoi. id teres, (such as stress, kidney malfunction, high blood pressure, water retention, • With a certain amount of olein and lack of sleep have been identified as being associated with the problem. Intrinsic aging and damage relative to light can also lead to similar changes. The increased accumulation of "GAG'S" (hyaluronic acid and chondroitin sulfate B) can also lead to secondary osmotic changes that result in increased extracellular accumulation of prolein, sodium and water. In such cases, the affected skin appears edematous with pronounced lymphatics and vessels, and worn and numbed collagen fibers appear microscopically. A classic example of acute periorbital edema and discoloration is commonly referred to as "black eye" resulting from physical trauma to the eye and damage to the skin surrounding the eye. Here the trauma causes a vascular effusion that manifests as the classic periorbital contusion.

The use of ferment (genus, Saccharomyces) for the cooking preparation (species: Sacc aromyccs ccrcvicea) has registered in iixia the trayrect? Ii? of history but U scientific manipulation and the use of its derivatives of such technology in cosmetic products is only a recent phenomenon. For example, U.S. Patent No. 5,204,105 describes an emulsified cosmetic composition for the treatment of the skin beneath the eyes. The primary components defined in patent number .7.04. 105 are a mixture of plant extract, beta-carotene, vitamin C, and a mcti-silanol complex. The level of patent number 5.204.105 assumes that a n-c / .ele of substances that occur naturally will have some (unidentified) benefits for the skin, but patent number *. 704.1 .1 *. it actually identifies the methyl-silanol complex (not from the ferment or plant) as the active ingredient "to minimize the blackness" in the lower eyelids of the eyes. U.S. Patent No. 5,223,491 describes the use of? Glucan insolublc from yeast cell ferment walls to "revitalize" the skin; and the Japanese publication of Patent No. 7-10734 (1955) describes the use of a culture of grain ferment isolated and grown in Jeche to reduce mediated hyperpigmentation of meianocyst. These descriptions are typical of the state of the art that is directed superficially to the use of non - animal derived products to benefit the skin under the current tendency of consumer pressures to use in the cosmetics menoe ingredi derived from animals. A deeper reading identifies a non-ferment active ingredient or that healthy origins such as giauo or milk have little to do with their active properties. Jin the specialty there is a need for a therapeutic dermal composition., functional, derived from ferment that lightens the decoloramicnto and the formation of bags that are in the facial skin under the eyes. Straw end. The present invention includes the following objectives. OBJECTIVE OF THE INVENTION The object of the present invention is to provide one. composition for the local treatment of skin abnormalities that include ntuiu icci 'id and discoloration that is found in the lower eyelids of the eyes. <; > The objective of the present invention is to provide a composition comprising cell ferment derivative to reduce the formation of pockets in the lower eyelids under the eyes and the associated discolorations. A further object of the present invention is to provide a composition containing a selected range of cell ferment derivative, which also contains selected ranges of magnesium ascorbyl phosphate and vitamin A derivatives. and vitamin E, to provide benefits that include reduced pocket formation in the lower eyelids under the eyes. Phases and other objectives will be evidenced in an apparent way from the revelation provided in the present. THE INVENTION The present invention is the local formulation for the treatment of pocket formation in the lower eyelids under the eyes and the associated discolorations, which comprises approximately from 0.5 to about 10.0 per cent of derivative of cell ferment, from about 0.5 to about i 0.0 percent magnesium aspnrhtl phosphate, from about 0.01 to about 1.0 percent retinol paimitate > and a vehicle that maintains the levels of the active ingredient. The formulation can be prepared in several different vehicles. For example, how can cream be about 8.5 per cent of emollient oils, about 7.5 percent? Jivcrsn3, approximately 5.0 percent of giieerin, approximately "3," 2 percent cent of the cell ferment derivative. about 3.0 percent magnesium ascorbyl phosphate, about 1"0 percent tocopherol acetate, about 0.7 percent retinol palmitate, about 0.7 percent vitamin derivatives and other vitamins, about 2 percent. , percent emulsifiers and approximately 0.35 percent thickeners. One embodiment in lotion may have about 10.0 percent emollient oils, about 5.0 percent glycerine. about 4.75 percent of various waxes, about 3.5 percent magnesium ascorbyl phosphate, about 3.25 percent cell ferment derivative, about 1.0 percent tocopheryl acetate, about 0.25 percent of rerinol palmitate. about 0.8 percent of vitamin derivatives, and you will hear vitamins, about 1.75 percent emulsifiers and about 0.35 percent thickeners. One gel permeation function may have approximately 1.5 percent of emollient protein, approximately 1.5 percent of glyceppa, approximately 5.0 percent of cell ferment derived, approximately 2.0 percent of phosphate. magnesium ascorbyl, approximately 0.1 percent tocopherol acetate, approximately 0.1 percent palmitate, approximately 0.2 percent by-products of vitamins and other vitamins, approximately 1 percent. percent emulsifiers and approximately 0.75 percent thickeners. In preferred embodiments, all percentages are excreted by the relative weight of the ingredients to the total weight of the composition, glycerin acts as a humectant, emollient oils may include dioctyl maleate, Grape seed and sunflower, and squashed, the various waxes contemplated include soybean sterols, uracer monostearate, cetyl alcohol and myristate mirisulum, derivatives of vitamins and other vitamins may include vitamin K. and palmitate ascorbyl, emulsifiers that are may include PEG 40 stearate, cologlyl ether PEG 24 and polysorbate 20, and various thickeners may also be used, such as xanthan gum and carbopoles 934 and 941. In addition, oral anti-inflammatories, such as bisabilol, neutralizers and pH regulators. , such as potassium hydroxide, citric acid and sodium citrate, stabilizers such as silicon dioxide and zeolite; preseivants such as methylparaben; urea imi azoiidinyl and alcohol hendi; «Antioxidants such as BHi; chelators such as tetrasodium EDT ?; and various plant and botanical extracts and fragrances known to those skilled in the art may all be employed in various combinations of the present invention to enhance efficiency and impart to the foot! general beneficial effects. The local compositions comprising the present invention contain derivatives of living cell ferment (hereinafter also referred to as "LYCD") as the active ingredient in an appropriate formulation for the treatment of problems of the lower eyelids of the eyes. As dark circles and lor ation of bags, as previously noted, dark circles are not a simple problem of melanocyte-mediated pigmentation.The etiologies include neither the functions of ci? culdtoria, inil-imaeion and exposure to the surrounding environment, and the The problem does not respond well to known hypopigmentation or skin bleaching compounds The LYCD-containing compositions of the present invention provide a practical alternative for the circles of the lower eyelids of the eyes RL LYCD is a highly complex hinlo-active material. , of low molecular weight, comprised of amino acids, monosaccharides and disaccharides and points amounts of vitamins and minerals. The LYCD as such is l? used in the present invention is produced from the ferment of volatile cultures of Saccharnmyceg erevicia and consists primarily of giicoeidicas and eptídicas fractions resulting from the extraction of ferment of living cells subjected to ultra-violet (UV) tension, which causes the cells to synthesize "protective" chemical entities. These active substances promote IR uptake and enhancement of metabolic processes within human cells. For example, these materials have been reported to produce collagen in fiber chirps.

"Br <? > k: > and c? Lab? Iadof," Live Yeast Ceü Derivalive. Cosmctics & Toiletry - "(Live Cell Derivatives, Cosmetics and Perfumery), Ü: 65-70 (1995) As noted above, the present ormilations may contain vitamins A, C, E, and K and its derivatives, phospholipids and bisabilyl to promote other cosmetic benefits.In addition, LYCÜ, when combined with magnesium ascorbyl phosphate (M? P), tocopheryl acetate, and retinol palmitate, produces surprising benefits. ppra illuminate the dark circles of the lower eyelids of the US L-uili / local regulate., two \ aes a day of such mixtures priduce dramatic, tangible improvements in the dark circles of the lower eyelids of the eyes »Within two weeks DETAILED DESCRIPTION OF THE INVENTION The theory that lies behind the derivative of the living cell ferment (" LYCD ") is based on the response of the life cell to the trauma.A damaged cell, reflexively produces self-prot substances ectora LYCD used in this disclosure is manufactured from live cell ferment cultures by modifying their medium to select the metabolic processes that produce a particularly useful, safe cosmetic material. The ferment cultures are placed in a feeds and brought to viability in an appropriate nutrient medium with complete aeration under an i > m ftrAi? iM controlled. The VÍVBS cells are then tensioned with ultraviolet light (UV) 1286 nm). The cells respond by producing two protective substances. The biochemicals of the cells can be monitored by absorption assay at 25b to 258 nm with a UV spectrotometer. Exposure to ultraviolet light is continued, for up to several days, the complex biochemical protective mechanism must be complete. The fermentation is stopped by means of the propagation of the walls of the cell with a proteolytic enzyme. The insoluble material of the cell wall is repaired with centrifugal and the cellular protnplasma is collected. The soluble asthmatic protopl extract is then concentrated and tested for biological activity. The former LYCD can be concentrated either by drying in refrigeration or by spray drying, and is usually available as a degree of cosmetic solution, such as "Brooks Inc.", "South Plainfield", "New" Sweater". Extensive analyzes have shown that the LYCD consists of low molecular weight peptide / glycosidic fractions between 400 to 3.) or daltons, the peptide to glycosidic ratio being about 3: 1. The chains of glycopeptide are through asparagine ortoglycoside residues. There are also marked amounts of coenzyme-type vitamins typical of ferment préseme, cnnjnntí-m: .ntr. Co-factor type minerals. "Jirooks et al., Cited work, 14. The following exemplary embodiments were made in accordance with the foregoing invention.

The exemplary embodiments shown in Table 1 serve only to illustrate but not to limit the invention. One skilled in the art could apply the disclosure provided herein to develop additional embodiments and other suitable vehicles without departing from the scope of this invention. The above exemplary embodiments were made following a similar protocol to that which is delineated further, which serves for the cream embodiment. EXAMPLE 1 PREPARATION OF THE CREAM FORMULA neither primary equipment used to perform the cream reaction form was a "Presindu3tria <1 - ppenbach" with a team capacity of 60-90% for? Ok:? T. cn. 12! auxiliary equipment included three side boilers, boiler number 1, with 30% by volume, boiler number 2, with 30% by volume and boiler number 3, with 35% by volume. The batches were carried out in the ressindustria / I penhach equipment, using high-speed grinding when the grinding is specified below, demineralized water (percentage by weight: 20.82) was added to the side boiler number 1. With moderate mixing, Then added gliuerine and tetrasodium EDTA and mixed for 5 to 10 minutes until a uniform consistency was achieved.Arbopol 934 was slowly spread as rain inside boiler number 1 and mixed vigorously for 60 to 90 minutes, until The Xantham gum was slowly dispersed in the form of rain within the boiler number 1 and mixed vigorously for 60 e 90 minutes, which reached a uniform consistency The contents of boiler number 1 were then cast (200 microns or finer) within the "Pres-» industry Eppepba lV 'and subjected to thermal action at 170 ° - 175 ° F (77 ° -79 ° C) with mixing. Desmineraided water (percentage by weight: 0.67) was brought into boiler number I and was subjected to the thermal action at 0 ° -175 ° F (77 ° -79 ° C), then transferred to a colander (200 microns or thinner) within the "Pressind? stría / Eppenbach" team. spilling the lateral boiler number 1 in such a way and connecting the pumps and the lines.

A pre-mix of 1.0 percent by weight of demineralized water and potassium hydroxide was made in a suitable container and transferred doiv.i? of the team "P cssindusLi iit / Epp iibacli". The temperature was maintained at 170 ° - 175 ° ¥ (77c-79 ° C) with a good ms / clade.

Vitamin A palmnato, glyceryl monostearate. cetolic alcohol, myristyl morostate PEG 40, soy ß6terolcs, colostrile ether PEG 24, silicon dioxide, methylparaben, BJIT, maleate di? lime, and squalune fuci? n to irrigated I read Humen you inside the lateral boiler number 2 and subjected to the thermal action to ¡90 * -195 ° F (X8Âß-9 I C C.) and mixed until you achieve a uniform texture. Palmitado ascorbyl, acetate tocopherol, soy bisabilol.lccitina / colcstcrol mixture, grape seed and sunflower oils were then argdos »slowly inside the lateral boiler number 2 with a temperamra maintained at 170u - 175u F (77ü-79ü C ) and mixed during! S to 20 minutes.

Ester of corn starch, silica globule and ccolite were then added into the number 2 boiler with a tcmwible maintained at 170 ° - 175 ° F (77 ° -79 ° C) and mixed, then, the contents of the boiler lateral number 2 were translucent. 1 equipment "Presttiir.dustria / Eppenbach" The heat was maintained at 170 ° -175 ° F (77 ° 79c C) with good mixing. The demincralized water (percentage by weight: 0.66) was discharged from boiler number 2 and subjected to the toric action at 170 ° - 175 ° F ', 77 ° -79 ° W), then transferred from the equipment "Pressindustria Eppenbaeh ", to spill the lateral boiler number 2, connecting! Cs oomba? > ! a.t Ur.eua. The batch in the "Pressindustria Eppenbacli" equipment ground and mixed cured for 5 to 10 minutes while maintaining the temperature at 170'- -175"1- (7 -'- ^ (_"> The batch was then cooled to 12Ü ? -125"F (49 ° -5 s) while re n-.c claba Arsin-injected water (percentage by weight:) to side boiler number i and subjected to thermal action at 120a -125 ° F (49 ° - Then, citrate of podium and citric acid was added to the water and then mixed until a uniform texture was obtained, as well as magnesium ascorbyl phosphate was added very carefully in the form of rain inside the number boiler and mixed at a temperature not exceeded the 125 ° F (52 ° C). Vitamin was then added and mixed for 5 to 10 minutes until a uniform texture was obtained. With the mill in operation, the contents of boiler number 3 were then cast (200 microns or finer) within the "Pressindustria /? Ppenbach" team. Demineralized water (percentage per poao: 0.67) was added to the lateral boiler number 3, luefco t nsferida to iravés of a colander (200 mieioues or finer) within the team "Pressindusíria / Eppenbach". to spill the lateral boiler number 3, connecting the pumps and the lincas. The batch was milled for 5 minutes and slowly mixed for 10 to 15 minutes until it formed a uniform texture, then cooled to 15 ° -20 ° F (46 ° -49 ° C) while the mixture continued slowly. A premixture of 2.0 percent by weight of demineralised water, urea imidazoii Jinil and LYCD was made in a suitable container to achieve a uniform texture, then transferred into the "PretJ-idustria / Eμ? Cnbadi" box. , Baking was mixed slowly for 10 to 15 minutes until a uniform bread was added. Then, tetramer eielomethicone and benzyl alcohol were added to the "Pressindutria ?? ppenbach" team, then mczclad? 3 slowly for 10 to 15 minutes until a uniform texture was obtained.

EXAMPLE 2 STUDY OF THE TREATMENT FOR THE PARAPADOS LOWER OF THE EYES Under the supervision of a logo, the formulation of the cream as previously specified was tested in a panel of 50 women who had discoloration and facial bag formation under the eyes. More specifically, some panellists had "rhinopy circles," which were classified by the researchers as discolorations and resulting bag formations from capillary spills within the tissue surrounding them. Other factors contributing to the flushing of the circles were attributed to the visibility of capillary walls or the dilatation of the blood vessels in panellists with relatively more transparent skin. The effect of bluish purple on the area of the lower páfado below the eyes of those panelists with dermic circles was more pronounced in the panelists. standing! more Jai a. Oo-a category of fading manifested was a "mixed" type, the C? UI the an *! The islands exhibited a combination of dermal and "epidermal" circuits. In addition to the dermal circles, the mixed type also has a hyperpigmontaclon pattern, which is more common in darker-skinned panelists and those with fair skin, which are akin to aging. Age and damage caused by clarity accented the effects * »The cream was applied in a divided way, that is, an area of the lower eye p? fao (right or left) received the active ingredient, while the other was not treated. The local application treatment was performed twice or day under conditions of randomisation. Specifically, the cream was applied to all of the "crow's feet" under the eyes and cheek areas twice a day (in the morning and by the day) for the entire study. No gold product 5 was used to care for the skin in the area of the lower eyelids of the eyes during the study. The panelists were set up to clean their faces! As if it were a normal routine and every morning and evening to use one or two points of cream on the tips of the fingers and apply- gently under the designated eye, crow's feet and areas of the upper cheekbone. The dermatologist examined the areas of the lower eyelids of the eyes of the application sites of the cream of the invention and compared them with the places containing contiol at intervals of 2, 4, 8 and 12 weeks. The intensity of color in the area of the lower eyelids of the eyes in which it applied to the cream that enriched 1 YO) was significantly reduced in most lae panelistss at a time ran early as two weeks after dr. the application. Improvements were observed in the lines and le? Luia, a decrease in the swelling of the suborbital area and reductions in the intensity of the color of the area in the panelists during four weeks. of the application (See Tables 2> 4 below). «? 0 A reduction in the intensity of the color meant that the affected skin achieved a mush tone, and a reduction in the color of the area meant a reduction in the amount or scope of the coloration, with improvement, which begin? from the outer areas (corner of the eye and upper part of the eye) and decreasing er. water direction to the lower dpa area of * o Layer 2 then ria a stepped score for the different par? Nneuc. *.-Ometidoa to test. TABLE% a Table 3. then show the percentage < %) of the panelists somcüda-j to test that shows improvement at each point of time.

TAJ3J T »? Tühlii A sc . { /.ji(lnmenl.t .. r-.s ?? the combined sensory and clinical dalos.

ABLA 4 i: IMPROVEMENTS, BY EVALUATION OF THE DERMATOLOGIST •? SIGNIFICANT AYAZGO: OPINION OF BREAD LOSTAS »THE TESTS SHOW: After 2 weeks: The skin around the eyes looks softer; fine lines and wrinkles ee soften. - After 4 weeks: Dark circles are clearer in 8 out of 10 panelists * and intumescence is decreased + e S sfirr.flíw T .os lauro circles are significantly less noticeable. +: sensory finding - * clinical finding.

S may appreciate various categories and definitions of the present invention, based on the study of this revelation, and attempts to make these aggregate changes within the scope and spirit of the present invention, as defined by - So the following indications.

Claims (1)

1. RE I V I ND I CA C I O N S 1. - A composition for the local treatment of discolorations of the foot! which is located under the lower eyelids of the eyes, characterized poique comprises: 5 (a) approximate? t.eme 0.5 to about 10, U% of living cell derivative of ferment, (b) about 0.5 to about 10.0% magnesium ascorb-1 phosphate, (c) about OJ to about 5.0% tocopherol acetate, (d) about 0.01 to about 1.0% retinoid palmitate], and ( e) a vehicle, which maintains the levels of active ingredient 2. The composition of claim 1. characterized in that 15 comprises; (a) about 8.5% of emollient oils, (b) about 7.5% of waxes, (c) fi n? x¡? ríir¡¡ '', e.?.c.l% g ? cerin, (d) about 3.52% of live cell derivative of ferment. 20 (e) about 3.0% magnesium ascorbyl phosphate, (0 about 1.0?) And tocopheryl acetate, (.beta.) "Proxvn..d ... Tiftwe 0, from pa.mitate rctinol. (h) approximately 0.7% of vitamins derived from vitamins, (i) approximately 2.5% of emuisificuntes, and "&?> 0) opv &? m -?:. unc - *. te 0.35% of cspcs & dies. 3. The composition of claim 2, characterized in that said emollient oils are selected from the group consisting of: maleate dioctii, grape seed and sunflower seed oils, and squalane, said waxes being selected from the group consisting of: sterols soybean »monostearai? iicerii, cetyl alcohol, and myristyl myristate, said vitamins and vitamin derivatives are selected from the group consisting of vitamin K and aecorbi palmitate, said emuliners are selected from the group consisting of: PEO 40 stearate, colsleril ether PEG 24, and polysorbate 20, and said thickeners are selected from the group consisting of: xanthan gum, Carhnpolcs 934 and 941. 4. The composition of claim 1, characterized in that it comprises: (a) about 10, 0% of emollient oils, (b) about 5.0% of yuecrein, (c) n = 0.5 mt. Of waxes, (d) about 3.5 mg of magnesium ascorbyl phosphate, (e) about 3.25% d da ivad? live cell ferment, (0 approximately! 0% acetate tocopherol, (g) ¡.provimadamctit: '' 1,25 palmitate retinol, (h) approximately 0.8% vitamin V and vitamin derivatives, (i) approximately 1.75% of cmu if.cantes, and íj) aptoximadjnienie 0.35% ds thickeners. 5.- T a compo? Ii-uVt He * 'a claim 4, caracterizad:! because said ruminant oils are selected from the group consisting of: male, dioctyl, grape seed and sunflower seed oils, s ualane; said waxes are selected from the group consisting of: soy sterols, glyceryl monostearate, cetyl alcohol, and roirisullar myristate; Are said vitamins and vitamin derivatives selected? l fciup? which consists of: vitamin K and palmilat? ascorbik said emulsifiers are selected from the group consisting of: stea ato PJiü 40, ether colstßril PEG 24, and poiisorbate 2U; and said thickeners are selected from the group consisting of: xantham gum, Curbopolcs 934 and 941. 6. The composition of claim 1, characterized in that it comprises: (a) about 1.5% of milling oils, (b) approximately 1.5% glyccrine, (c) approximately 5.0% live cell derivative of ferment, (d) about 2.0% magnesium ascorbyl phosphate, (e) about ü, i% acetate toeopherol, (f) about 0.1 ° ?: palmitinotoctinol, (g) about 0.2% vitamins > derived-, have vitamins. (h) about 1.5% emulsifiers. and (j) approximately, 7 ^% of thickeners. - The composition of claim 6, characterized in that said cn-.oHcntc oils selected from the suupo consisting of: maito di? iil, it de pepiu :. of grape and Je sunflower seeds, and squalane; said-! Vitamins and vine derivatives are selected from the group that contains. itamina K and paimitato ascorbyl; said--: t-selected toners of the pc consisting of d: PEG 40 isterate, cologlyl ether PEG 24, poiisorbate 20; and thickeners are selected from the group consisting of; xantam gum, Carbopales 934 and 941. 8.- \ In the course of the local treatment of discoloration-, of the skin under the lower eyelids of the eyes, characterized by the application of a composition of acueido tonia. claim 1, and consisting of: (a) about 0.5 to about 10.0% ferment live cell derivative, (b) about 0.5 to about 10.0% ascorbyl phosphate! of magnesium, (c) about 0.09 to about 0.6% palmitate retinol, (d) about 0.1 to about 5.0% acetate tocopherol, and (c) a vehicle, which maintains the levels of active ingredient. and - The method of claim 1, characterized in that said composition comprises: (a) about B, 5% oils, and (b) about 7.5% waxes. (c) aprnximad, '- mt »n, ¡!' 5.0% glycerin, (d) approximately 3.52% live cell derivative of ferment, (e) api cximadam ntc?, 0 ^ magnesium ascorbyl phosphate. (f) approximate ?; m sute * .0 d acela.o locoferol, (g) approximately 0.5%? \ - palmitarc r- t.no-, (t?> about 0.7 or of vitamins and vhaminaa derivatives. (i) about 2.5 Y of emulsi fi ers, and (j) about 0.35% thickeners 10. The method of claim 9, characterized in that said emollient oils are selected from the group consisting of: dioctyl maleate, pq. Grape seeds and sunflower seeds, and squanane, said waxes are selected from the group consisting of: soybean sterols, monostearate glyceryl, cetyl alcohol, and myristyl myristyl, said vitamins and vitamin derivatives being selected from the group consisting of of vitamin K and ascorbyl palmitate, said cmulsified are selected from the group that you ate of: stearate PEG 40, ter colsteril PFG 24, and polysorbate 20, and drhns ospesaderes are selected from the group consisting of: gum xantam, Carbopole .. 934 and 941. 11.- The method of the claim n 8, characterized in that said c? n.xx iciúi; understands; Ca) approximately 10.0% of emollient grades, (b) approximately 5.0% of liqueur. (c) approximately 4.75% waxes, (d) a.i.Oxi-aminoinent 3.5% of magnesium lob-bile, (c) about 3.25% of living cell derivative m * ferment. (f) approximately 1.0 tle acetate tccoferol, (g) approximately 0.25% retinoid palmitate, (h) apro.? r_adar.?eute O.S% of vi laminas and derivatives »Je vitamins. í¡ > approximately 1.75% of kinulsifiers, and (j) a? ro > : i? r, .ip.'tmpnic O. ^ í. % thickeners. 12.- L! The method of claim 1 characterized in that said .ceite-; emolientes n 'jeleccionudoj the group consisting of. maleate T > dioctyl, oils from grapes and sunflower seeds, and squalane; said waxes are selected from the group consisting of: soy sterols, monostcareto glyceri), cetyl alcohol, and myristate mirisil ?; said vitamins and derivative *, of vi minina s > They are selected from the group consisting of: vitamin K and pal itato ascorbyl; said emulsifiers. they are selected from the group consisting of: stearate PEG 40, colsteryl ether PEG 24, and polysorbate 20; and said thickeners 3on selected from the group consisting of: xautam gum, Carbopole-. 934 and 941. 13. The method of claim 8, characterized in that said composition comprises: (a) about 1.5% emollient oils, (b) about 1.5% glycemia, (c) about 5.0% live ferment cell derivative, (rf) about 2.0% magnesium ascorbyl phosphate, (©) about 0.1% tocopherol acetate, (f) about 0.1% rctinol palmitate, í¿) approximately 0.2 of vitamins and vitamin derivatives. (h) about 5% of emulsifiers, and j) approximately 0.75% of weight. 14. The method of claim 13, characterized by said emollient oils ?, are selected tlel giupo consisting of: dioctyl maleate. Grapeseed and Giraso1 seed oils naJane; said vitamins and vitamin C derivatives are selected from the group consisting of: vitamin K, paimitato ascorbyl, dich n, cmulsifieadorcs are sclccc /? nad.T. d 'group consisting of: cstearatr. PEG 40. ici c? Lbleni PEG 24, and polys? Bato 20; and said thickeners are selected from the group consisting of: xantam gum, CarbopoJes 934 and 941. 15.- A composition stops the local treatment of discolorations of the skin that is under the lower eyelids, eyes 5, according to claim 1. , characterized in that it comprises: (') about 0.5 to about 10.0% ferment live cell derivative, (b) about 0.5 to about 10.0% magnesium ascorbyl phosphate, 10 (c) a vehicle that maintains active ingredient levels. 16. The composition of claim 15, characterized poique further comprises: approximately 0, From 1 to about 5.0% lüc? Ferol acetate. J7.- The composition of claim 15, characterized in that it further comprises: about 0.01 to about 1.0% palmitate rctinol. 18.- U mú / d? according to claim 8. for the local treatment of discolorations of the skin that is placed under the eyelids mf pores of the njoi. characterized in that it comprises the application of a composition comprising up to about 10.0 of a live cell stalk of ferment, and a vehicle that maintains the levels of active ingredient. i l >; .- A composition for the local treatment of the intumescence of the skin that is under d? the lower eyelids of the eyes, - > c: .3gun h claim I. characterized by comprising about 0.5 to about. 1.0% live cell derivative of ferment in a vehicle that maintains active ingredient levels. 20. - The composition of claim 19, characterized in that it further comprises: about 0.5 to about 10.0% magnesium astorbyl phosphate. 21. The composition of claim 19, characterized poique further comprises: about 0.1 to about 5.0% tocopherol acetate. 22. The composition of claim 19, characterized in that it further comprises: from about 0.01 to about 1.0% of retino palmitate !. 23. The composition of the claim 19, characterized in that it further comprises: a compound selected from the group consisting of from about 1.0 to about 9.0% emollient oils, from about 4.0 to about 8. , 0% waxes, from about 0.5 to about 6.0% glycerin. from about 0.1 to about 0.9% .V. Vitamins and Vitamin Derivatives, from about 1.25 to about 2.75% of emulsion and of approx. go. -0.3 to approximately 0.8 ° 'or e-weighers. 24, - The con ?? u ..? > n of lti le reivindic &23, caracrer-xada because said emollient oils are < The action of the group consisting of: dioecious maleate, grape seed and pip-seed oils; of ¿resol, and squaiane; said waxes ..op selected do! group consisting of: stems, soya, monostearat glycerii, ethyl alcohol, irishium isis: said vitamins, and vitamin derivatives are selected from the group consisting of: vitamin K and ascorbyl palmitate; said emulsifiers are selected from the group consisting of: stearorate PCC 40, ether eolsteril PEG 24, and polysorbate 20; and said thickeners are selected from the group consisting of: gum xanuuiit Carbopoles 934 and 941. 25.- A method according to claim 8, for the local treatment of the intumescence to the skin that is under the lower eyelids of the Eyes, characterized in that it comprises the application of a composition comprised from about 0.5 to about 10.0% of live cell derivative of ferment in a vehicle that maintains the levels of active ingredient. 26. The method of claim 25, characterized in that said composition further comprises: about 0.5 to about 10.0% magnesium ascerbil phosphate. 27.- Fl nvindo of claim 25. characterized in that said composition further comprises: from about 0.1 to about 5.0% of acetate tocopherol. 28.- The mél? D? of claim 25, characterized in that said composition further comprises: from about 0.01 to about 1.0% d retinal pannitol !. 29. The method of claim 25, characterized in that said composition further comprises a compound selected from the group consisting of from about 1.0 to about emollient oils, from about 4.0 to about 10% of zeros, from about OS to about 6.0% glycerin, from about 0.1 to about 0.9% of vitamins and vitamin derivatives, from about 1.25 to about 2.75% of emulsifiers and about 0.3 to approximately 0.8% thickeners. 30. The method of claim 29, characterized in that said emollient oils are selected from the group consisting of: dioctyl maleate, grape seed and sunflower seed oils, and s? Ualane; said waxes are selected from the group consisting of: soy sterols, giieeril onostearate, cellylic alcohol, and myristate mirisril; said vitamins and vitamin derivatives are selected from the group consisting of: vitamin K. and ascorbyl palmitate; said emulsifiers are selected from the group consisting of: stearate PEG 40, colsteryl ether PEG 24, and polysorbate 20; and said thickeners are selected from) group consisting of: xantha gum, Carbopol s W4 and 941. SUMMARY A composition and a method for the local treatment of the foot is disclosed, comprising the use of live cell derivatives of ferment in combination with a suitable vehicle for the treatment of discolorations and intumescences in the facial skin of the lower eyelids of the eyes.