MXPA06000447A - Derivados de pirrole-2,5-ditiona en la forma de moduladores receptores de higado x. - Google Patents
Derivados de pirrole-2,5-ditiona en la forma de moduladores receptores de higado x.Info
- Publication number
- MXPA06000447A MXPA06000447A MXPA06000447A MXPA06000447A MXPA06000447A MX PA06000447 A MXPA06000447 A MX PA06000447A MX PA06000447 A MXPA06000447 A MX PA06000447A MX PA06000447 A MXPA06000447 A MX PA06000447A MX PA06000447 A MXPA06000447 A MX PA06000447A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- phenyl
- amino
- compound
- prophylaxis
- Prior art date
Links
- 102000004311 liver X receptors Human genes 0.000 title abstract description 39
- 108090000865 liver X receptors Proteins 0.000 title abstract description 39
- DVUZQONFTJKFPV-UHFFFAOYSA-N pyrrole-2,5-dithione Chemical class S=C1NC(=S)C=C1 DVUZQONFTJKFPV-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 292
- 238000000034 method Methods 0.000 claims abstract description 103
- 201000001320 Atherosclerosis Diseases 0.000 claims abstract description 22
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 19
- 208000024172 Cardiovascular disease Diseases 0.000 claims abstract description 15
- 208000032928 Dyslipidaemia Diseases 0.000 claims abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
- 206010022489 Insulin Resistance Diseases 0.000 claims abstract description 6
- 150000002632 lipids Chemical class 0.000 claims abstract description 5
- 230000008569 process Effects 0.000 claims abstract description 3
- 239000012453 solvate Substances 0.000 claims description 245
- 150000003839 salts Chemical class 0.000 claims description 239
- 238000011282 treatment Methods 0.000 claims description 108
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 72
- -1 3-pyridylmethyl Chemical group 0.000 claims description 71
- 238000011321 prophylaxis Methods 0.000 claims description 67
- 239000003814 drug Substances 0.000 claims description 51
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 50
- 238000004519 manufacturing process Methods 0.000 claims description 45
- 241000124008 Mammalia Species 0.000 claims description 30
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 27
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 26
- 235000012000 cholesterol Nutrition 0.000 claims description 24
- CFHGBZLNZZVTAY-UHFFFAOYSA-N lawesson's reagent Chemical compound C1=CC(OC)=CC=C1P1(=S)SP(=S)(C=2C=CC(OC)=CC=2)S1 CFHGBZLNZZVTAY-UHFFFAOYSA-N 0.000 claims description 24
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 22
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 108010010234 HDL Lipoproteins Proteins 0.000 claims description 12
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- 208000035150 Hypercholesterolemia Diseases 0.000 claims description 10
- 208000024827 Alzheimer disease Diseases 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims description 8
- 208000017170 Lipid metabolism disease Diseases 0.000 claims description 8
- 238000010521 absorption reaction Methods 0.000 claims description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
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- 108010028554 LDL Cholesterol Proteins 0.000 claims description 7
- 238000008214 LDL Cholesterol Methods 0.000 claims description 7
- 239000003085 diluting agent Substances 0.000 claims description 7
- 230000000968 intestinal effect Effects 0.000 claims description 7
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 6
- 206010061218 Inflammation Diseases 0.000 claims description 6
- 208000011775 arteriosclerosis disease Diseases 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
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- 108010023302 HDL Cholesterol Proteins 0.000 claims description 5
- 229910003827 NRaRb Inorganic materials 0.000 claims description 5
- 238000011161 development Methods 0.000 claims description 5
- 125000001072 heteroaryl group Chemical group 0.000 claims description 5
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- DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 4
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- MOHJWUULCVHTNF-UHFFFAOYSA-N 1-[(6-aminopyridin-3-yl)methyl]-3-(4-morpholin-4-ylanilino)-4-phenylpyrrole-2,5-dithione Chemical compound C1=NC(N)=CC=C1CN1C(=S)C(C=2C=CC=CC=2)=C(NC=2C=CC(=CC=2)N2CCOCC2)C1=S MOHJWUULCVHTNF-UHFFFAOYSA-N 0.000 claims description 3
- BYRPUFZFUOVSDM-UHFFFAOYSA-N 1-ethyl-3-(4-methoxyanilino)-4-phenylpyrrole-2,5-dithione Chemical compound C=1C=CC=CC=1C=1C(=S)N(CC)C(=S)C=1NC1=CC=C(OC)C=C1 BYRPUFZFUOVSDM-UHFFFAOYSA-N 0.000 claims description 3
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- 208000035475 disorder Diseases 0.000 claims description 3
- LTTHEZOLSVUPKW-UHFFFAOYSA-N 1-benzyl-4-(4-methoxyanilino)-3-phenyl-5-sulfanylidenepyrrol-2-one Chemical compound C1=CC(OC)=CC=C1NC(C1=S)=C(C=2C=CC=CC=2)C(=O)N1CC1=CC=CC=C1 LTTHEZOLSVUPKW-UHFFFAOYSA-N 0.000 claims description 2
- SNZKVZCTAGKILF-UHFFFAOYSA-N 1-butyl-4-(4-methoxyanilino)-3-phenyl-5-sulfanylidenepyrrol-2-one Chemical compound S=C1N(CCCC)C(=O)C(C=2C=CC=CC=2)=C1NC1=CC=C(OC)C=C1 SNZKVZCTAGKILF-UHFFFAOYSA-N 0.000 claims description 2
- SQUXAIADYPVBAH-UHFFFAOYSA-N 1-ethyl-4-(4-methoxyanilino)-3-phenyl-5-sulfanylidenepyrrol-2-one Chemical compound S=C1N(CC)C(=O)C(C=2C=CC=CC=2)=C1NC1=CC=C(OC)C=C1 SQUXAIADYPVBAH-UHFFFAOYSA-N 0.000 claims description 2
- 125000006479 2-pyridyl methyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims description 2
- ZEJARFJOUMEMPC-UHFFFAOYSA-N 3-(4-methoxyanilino)-1-methyl-4-phenylpyrrole-2,5-dithione Chemical compound C1=CC(OC)=CC=C1NC1=C(C=2C=CC=CC=2)C(=S)N(C)C1=S ZEJARFJOUMEMPC-UHFFFAOYSA-N 0.000 claims description 2
- YZOJWRMGECTRBU-UHFFFAOYSA-N 3-(4-methoxyanilino)-4-phenyl-1-(2,2,2-trifluoroethyl)pyrrole-2,5-dithione Chemical compound C1=CC(OC)=CC=C1NC1=C(C=2C=CC=CC=2)C(=S)N(CC(F)(F)F)C1=S YZOJWRMGECTRBU-UHFFFAOYSA-N 0.000 claims description 2
- FVYSXHCRUKAQCM-UHFFFAOYSA-N 3-(4-methoxyanilino)-4-phenyl-1-(pyridin-3-ylmethyl)pyrrole-2,5-dithione Chemical compound C1=CC(OC)=CC=C1NC(C1=S)=C(C=2C=CC=CC=2)C(=S)N1CC1=CC=CN=C1 FVYSXHCRUKAQCM-UHFFFAOYSA-N 0.000 claims description 2
- QDYXCIWVXFXUMP-UHFFFAOYSA-N 3-(4-methoxyanilino)-4-phenyl-1-(pyridin-4-ylmethyl)pyrrole-2,5-dithione Chemical compound C1=CC(OC)=CC=C1NC(C1=S)=C(C=2C=CC=CC=2)C(=S)N1CC1=CC=NC=C1 QDYXCIWVXFXUMP-UHFFFAOYSA-N 0.000 claims description 2
- IJRRWYZJKFXOMW-UHFFFAOYSA-N 4-(4-methoxyanilino)-1-methyl-3-phenyl-5-sulfanylidenepyrrol-2-one Chemical compound C1=CC(OC)=CC=C1NC1=C(C=2C=CC=CC=2)C(=O)N(C)C1=S IJRRWYZJKFXOMW-UHFFFAOYSA-N 0.000 claims description 2
- MQFQGAMIOKBKSC-UHFFFAOYSA-N 4-(4-methoxyanilino)-3-phenyl-1-(pyridin-4-ylmethyl)-5-sulfanylidenepyrrol-2-one Chemical compound C1=CC(OC)=CC=C1NC(C1=S)=C(C=2C=CC=CC=2)C(=O)N1CC1=CC=NC=C1 MQFQGAMIOKBKSC-UHFFFAOYSA-N 0.000 claims description 2
- CATPDSIFGQYWIV-UHFFFAOYSA-N 4-(4-methoxyanilino)-3-phenyl-5-sulfanylidene-1-(2,2,2-trifluoroethyl)pyrrol-2-one Chemical compound C1=CC(OC)=CC=C1NC1=C(C=2C=CC=CC=2)C(=O)N(CC(F)(F)F)C1=S CATPDSIFGQYWIV-UHFFFAOYSA-N 0.000 claims description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 2
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- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
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- 125000001589 carboacyl group Chemical group 0.000 claims 2
- IOIWSAHJOUDSRY-UHFFFAOYSA-N 1-benzyl-3-(4-methoxyanilino)-4-phenylpyrrole-2,5-dithione Chemical compound C1=CC(OC)=CC=C1NC(C1=S)=C(C=2C=CC=CC=2)C(=S)N1CC1=CC=CC=C1 IOIWSAHJOUDSRY-UHFFFAOYSA-N 0.000 claims 1
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- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0316237.7A GB0316237D0 (en) | 2003-07-11 | 2003-07-11 | Therapeutic agents |
| PCT/SE2004/001115 WO2005005416A1 (en) | 2003-07-11 | 2004-07-08 | Pyrrole-2, 5-dithione derivatives as liver x receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA06000447A true MXPA06000447A (es) | 2006-04-07 |
Family
ID=27741986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA06000447A MXPA06000447A (es) | 2003-07-11 | 2004-07-08 | Derivados de pirrole-2,5-ditiona en la forma de moduladores receptores de higado x. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20060189663A1 (https=) |
| EP (1) | EP1646625B1 (https=) |
| JP (1) | JP2007521313A (https=) |
| KR (1) | KR20060034284A (https=) |
| CN (1) | CN100478340C (https=) |
| AR (1) | AR045720A1 (https=) |
| AT (1) | ATE399776T1 (https=) |
| AU (1) | AU2004256000B2 (https=) |
| BR (1) | BRPI0412479A (https=) |
| CA (1) | CA2532068A1 (https=) |
| CO (1) | CO5640134A2 (https=) |
| DE (1) | DE602004014772D1 (https=) |
| ES (1) | ES2308205T3 (https=) |
| GB (1) | GB0316237D0 (https=) |
| IL (1) | IL172759A0 (https=) |
| IS (1) | IS8291A (https=) |
| MX (1) | MXPA06000447A (https=) |
| NO (1) | NO20060080L (https=) |
| RU (1) | RU2006102129A (https=) |
| SA (1) | SA04250203B1 (https=) |
| TW (1) | TW200507836A (https=) |
| UA (1) | UA82108C2 (https=) |
| UY (1) | UY28407A1 (https=) |
| WO (1) | WO2005005416A1 (https=) |
| ZA (1) | ZA200600229B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0500058D0 (sv) * | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 5 |
| SE0500055D0 (sv) | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 3 |
| JP2008526841A (ja) | 2005-01-10 | 2008-07-24 | アストラゼネカ アクチボラグ | 肝臓ｘ受容体調節因子としてのイソチアゾール−３（２ｈ）−オン１，１−ジオキシドのアニリン系誘導体 |
| US7989179B2 (en) * | 2005-06-28 | 2011-08-02 | Daiichi Sankyo Company, Limited | LXR ligand testing method |
| ES2528797T3 (es) | 2006-08-21 | 2015-02-12 | Genentech, Inc. | Compuestos de aza-benzotiofenilo y métodos de uso |
| WO2008046014A1 (en) | 2006-10-12 | 2008-04-17 | Remedy Pharmaceuticals, Inc. | Treatment of alzheimer's disease using compounds that reduce the activity of non-selective ca++- activated atp-sensitive cation channels regulated by sur1 receptors |
| US10004703B2 (en) | 2006-10-12 | 2018-06-26 | Biogen Chesapeake Llc | Treatment of alzheimer's disease using compounds that reduce the activity of non-selective CA++ activated ATP-sensitive cation channels regulated by SUR1 channels |
| WO2008103818A1 (en) * | 2007-02-21 | 2008-08-28 | University Of Louisville Research Foundation | Therapeutic cotinine compositions |
| ES2638977T3 (es) | 2007-12-04 | 2017-10-24 | Biogen Chesapeake Llc | Formulaciones y procedimientos mejorados para liofilización y liofilizados obtenidos por los mismos |
| US20110034560A1 (en) | 2008-01-29 | 2011-02-10 | Sven Jacobson | Liquid formulations of compounds active at sulfonylurea receptors |
| ES2426096T3 (es) | 2008-07-01 | 2013-10-21 | Genentech, Inc. | Derivados de isoindolona como inhibidores de la quinasa MEK y métodos de utilización |
| US8841462B2 (en) | 2008-07-01 | 2014-09-23 | Robert A. Heald | Bicyclic heterocycles as MEK kinase inhibitors |
| WO2012033353A2 (ko) | 2010-09-07 | 2012-03-15 | 서울대학교 산학협력단 | 세스터터핀 화합물 및 이들 물질의 용도 |
| WO2015106164A1 (en) | 2014-01-10 | 2015-07-16 | Rgenix, Inc. | Lxr agonists and uses thereof |
| EP3402477A4 (en) | 2016-01-11 | 2019-08-21 | The Rockefeller University | METHOD FOR THE TREATMENT OF DISEASES RELATED TO MYELOID-DERIVED SUPPRESSOR CELLS |
| CA3078981A1 (en) | 2017-11-21 | 2019-05-31 | Rgenix, Inc. | Polymorphs and uses thereof |
| KR200492570Y1 (ko) | 2018-12-04 | 2020-11-05 | 박규환 | 조립식 계단장치를 위한 발판 |
| TWI888447B (zh) | 2019-12-13 | 2025-07-01 | 美商因思博納公司 | 金屬鹽及其用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6111699A (en) * | 1998-10-08 | 2000-05-01 | Smithkline Beecham Plc | Novel method and compounds |
| JP2004500332A (ja) * | 1999-07-08 | 2004-01-08 | テュラリク インコーポレイテッド | Ｈｄｌコレステロール値を上昇させる組成物および方法 |
-
2003
- 2003-07-11 GB GBGB0316237.7A patent/GB0316237D0/en not_active Ceased
-
2004
- 2004-06-29 TW TW093119119A patent/TW200507836A/zh unknown
- 2004-07-05 SA SA4250203A patent/SA04250203B1/ar unknown
- 2004-07-08 ES ES04749151T patent/ES2308205T3/es not_active Expired - Lifetime
- 2004-07-08 AU AU2004256000A patent/AU2004256000B2/en not_active Ceased
- 2004-07-08 MX MXPA06000447A patent/MXPA06000447A/es not_active Application Discontinuation
- 2004-07-08 RU RU2006102129/04A patent/RU2006102129A/ru not_active Application Discontinuation
- 2004-07-08 BR BRPI0412479-0A patent/BRPI0412479A/pt not_active IP Right Cessation
- 2004-07-08 AR ARP040102418A patent/AR045720A1/es not_active Application Discontinuation
- 2004-07-08 JP JP2006520139A patent/JP2007521313A/ja not_active Withdrawn
- 2004-07-08 DE DE602004014772T patent/DE602004014772D1/de not_active Expired - Fee Related
- 2004-07-08 US US10/563,676 patent/US20060189663A1/en not_active Abandoned
- 2004-07-08 AT AT04749151T patent/ATE399776T1/de not_active IP Right Cessation
- 2004-07-08 CA CA002532068A patent/CA2532068A1/en not_active Abandoned
- 2004-07-08 WO PCT/SE2004/001115 patent/WO2005005416A1/en not_active Ceased
- 2004-07-08 KR KR1020067000616A patent/KR20060034284A/ko not_active Withdrawn
- 2004-07-08 EP EP04749151A patent/EP1646625B1/en not_active Expired - Lifetime
- 2004-07-08 CN CNB2004800197194A patent/CN100478340C/zh not_active Expired - Fee Related
- 2004-07-09 UY UY28407A patent/UY28407A1/es unknown
- 2004-08-07 UA UAA200600270A patent/UA82108C2/uk unknown
-
2005
- 2005-12-22 IL IL172759A patent/IL172759A0/en unknown
-
2006
- 2006-01-05 NO NO20060080A patent/NO20060080L/no not_active Application Discontinuation
- 2006-01-10 ZA ZA200600229A patent/ZA200600229B/xx unknown
- 2006-01-20 CO CO06005238A patent/CO5640134A2/es not_active Application Discontinuation
- 2006-02-09 IS IS8291A patent/IS8291A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UY28407A1 (es) | 2005-02-28 |
| SA04250203B1 (ar) | 2008-02-25 |
| WO2005005416A1 (en) | 2005-01-20 |
| ATE399776T1 (de) | 2008-07-15 |
| CN1820003A (zh) | 2006-08-16 |
| KR20060034284A (ko) | 2006-04-21 |
| HK1088318A1 (en) | 2006-11-03 |
| GB0316237D0 (en) | 2003-08-13 |
| CN100478340C (zh) | 2009-04-15 |
| EP1646625A1 (en) | 2006-04-19 |
| CA2532068A1 (en) | 2005-01-20 |
| AR045720A1 (es) | 2005-11-09 |
| IS8291A (is) | 2006-02-09 |
| IL172759A0 (en) | 2006-04-10 |
| UA82108C2 (uk) | 2008-03-11 |
| US20060189663A1 (en) | 2006-08-24 |
| DE602004014772D1 (de) | 2008-08-14 |
| JP2007521313A (ja) | 2007-08-02 |
| ZA200600229B (en) | 2007-04-25 |
| TW200507836A (en) | 2005-03-01 |
| AU2004256000B2 (en) | 2007-07-26 |
| BRPI0412479A (pt) | 2006-09-19 |
| NO20060080L (no) | 2006-02-08 |
| ES2308205T3 (es) | 2008-12-01 |
| AU2004256000A1 (en) | 2005-01-20 |
| CO5640134A2 (es) | 2006-05-31 |
| RU2006102129A (ru) | 2006-08-27 |
| EP1646625B1 (en) | 2008-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |