MXPA05011060A - Derivados de 2-azabiciclo[3.3.1]nonano como antagonistas del receptor opioide. - Google Patents
Derivados de 2-azabiciclo[3.3.1]nonano como antagonistas del receptor opioide.Info
- Publication number
- MXPA05011060A MXPA05011060A MXPA05011060A MXPA05011060A MXPA05011060A MX PA05011060 A MXPA05011060 A MX PA05011060A MX PA05011060 A MXPA05011060 A MX PA05011060A MX PA05011060 A MXPA05011060 A MX PA05011060A MX PA05011060 A MXPA05011060 A MX PA05011060A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- aza
- group
- bicyclo
- compound according
- Prior art date
Links
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- 201000006152 substance dependence Diseases 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000011593 sulfur Chemical group 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- BMHKMSRIOCQAES-UHFFFAOYSA-N tert-butyl 5-[3-(methanesulfonamido)phenyl]-2-azabicyclo[3.3.1]nonane-2-carboxylate Chemical compound C1CCC(C2)N(C(=O)OC(C)(C)C)CCC21C1=CC=CC(NS(C)(=O)=O)=C1 BMHKMSRIOCQAES-UHFFFAOYSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- YOIAWAIKYVEKMF-UHFFFAOYSA-N trifluoromethanesulfonic acid Chemical compound OS(=O)(=O)C(F)(F)F.OS(=O)(=O)C(F)(F)F YOIAWAIKYVEKMF-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229940072690 valium Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Neurology (AREA)
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- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46260503P | 2003-04-14 | 2003-04-14 | |
| PCT/IB2004/001237 WO2004089909A1 (en) | 2003-04-14 | 2004-04-02 | 2-azabicyclo[3.3.1]nonane derivatives as opioid receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05011060A true MXPA05011060A (es) | 2005-12-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05011060A MXPA05011060A (es) | 2003-04-14 | 2004-04-02 | Derivados de 2-azabiciclo[3.3.1]nonano como antagonistas del receptor opioide. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7056930B2 (enExample) |
| EP (1) | EP1615893B1 (enExample) |
| JP (1) | JP4493648B2 (enExample) |
| AT (1) | ATE449074T1 (enExample) |
| BR (1) | BRPI0409369A (enExample) |
| CA (1) | CA2522180C (enExample) |
| DE (1) | DE602004024188D1 (enExample) |
| DK (1) | DK1615893T3 (enExample) |
| ES (1) | ES2334570T3 (enExample) |
| MX (1) | MXPA05011060A (enExample) |
| WO (1) | WO2004089909A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| NZ531807A (en) * | 2001-10-22 | 2006-03-31 | Pfizer Prod Inc | 3-Azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists |
| MXPA05011070A (es) * | 2003-04-14 | 2005-12-12 | Pfizer Prod Inc | Derivados de 3-azabiciclo [3.2.1] octano. |
| US20050043345A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| TWI409067B (zh) * | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
| TWI425945B (zh) * | 2007-05-28 | 2014-02-11 | Seldar Pharma Inc | 四氫異喹啉－１－酮衍生物或其鹽 |
| ES2465621T3 (es) * | 2007-08-27 | 2014-06-06 | Theravance, Inc. | Compuestos de heteroarilalquil-8-azabiciclo[3.2.1]octano, como antagonistas de los receptores opiodes mu |
| US7947710B2 (en) * | 2007-08-27 | 2011-05-24 | Theravance, Inc. | Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| TWI423801B (zh) | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物 |
| EP2185553B1 (en) * | 2007-08-27 | 2012-06-27 | Theravance, Inc. | Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| GB0721178D0 (en) * | 2007-10-29 | 2007-12-05 | Glaxo Group Ltd | Chemical compounds |
| EP3610890A1 (en) | 2012-11-14 | 2020-02-19 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| JP5860192B2 (ja) * | 2013-11-20 | 2016-02-16 | 株式会社三和化学研究所 | 新規３−アザビシクロ［３．１．０］ヘキサン誘導体及びその医薬用途 |
| HK1246778A1 (zh) * | 2015-05-20 | 2018-09-14 | 株式会社三和化学研究所 | 一种新型的3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用 |
| EP3463361A4 (en) * | 2016-06-02 | 2019-11-27 | Virginia Commonwealth University | DUAL MODULATORS OF BOTH MU- AND KAPPA-OPIOD RECEPTORS |
| SG11202007422QA (en) | 2018-02-05 | 2020-09-29 | Alkermes Inc | Compounds for the treatment of pain |
| EP3768679B1 (en) | 2018-03-19 | 2024-06-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Biased potent opioid-like agonists as improved medications to treat chronic and acute pain and methods of using the same |
| KR102266854B1 (ko) * | 2019-11-06 | 2021-06-18 | 계명대학교 산학협력단 | 마약 중독 예방 또는 치료용 약학조성물 |
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| US2143145A (en) | 1934-11-06 | 1939-01-10 | Farnsworth Television Inc | Projection means |
| US6559159B2 (en) * | 2001-02-01 | 2003-05-06 | Research Triangle Institute | Kappa opioid receptor ligands |
-
2004
- 2004-01-22 US US10/762,730 patent/US7056930B2/en not_active Ceased
- 2004-04-02 JP JP2006506512A patent/JP4493648B2/ja not_active Expired - Fee Related
- 2004-04-02 AT AT04725453T patent/ATE449074T1/de not_active IP Right Cessation
- 2004-04-02 BR BRPI0409369-0A patent/BRPI0409369A/pt not_active IP Right Cessation
- 2004-04-02 ES ES04725453T patent/ES2334570T3/es not_active Expired - Lifetime
- 2004-04-02 CA CA002522180A patent/CA2522180C/en not_active Expired - Fee Related
- 2004-04-02 WO PCT/IB2004/001237 patent/WO2004089909A1/en not_active Ceased
- 2004-04-02 DE DE602004024188T patent/DE602004024188D1/de not_active Expired - Lifetime
- 2004-04-02 MX MXPA05011060A patent/MXPA05011060A/es not_active Application Discontinuation
- 2004-04-02 EP EP04725453A patent/EP1615893B1/en not_active Expired - Lifetime
- 2004-04-02 DK DK04725453.7T patent/DK1615893T3/da active
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2007
- 2007-10-18 US US11/874,253 patent/USRE40838E1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0409369A (pt) | 2006-04-25 |
| USRE40838E1 (en) | 2009-07-07 |
| EP1615893A1 (en) | 2006-01-18 |
| US7056930B2 (en) | 2006-06-06 |
| DK1615893T3 (da) | 2010-01-18 |
| EP1615893B1 (en) | 2009-11-18 |
| CA2522180C (en) | 2009-12-08 |
| CA2522180A1 (en) | 2004-10-21 |
| ATE449074T1 (de) | 2009-12-15 |
| DE602004024188D1 (de) | 2009-12-31 |
| JP2006522797A (ja) | 2006-10-05 |
| JP4493648B2 (ja) | 2010-06-30 |
| WO2004089909A1 (en) | 2004-10-21 |
| US20040204445A1 (en) | 2004-10-14 |
| ES2334570T3 (es) | 2010-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |