MXPA05009261A - Proceso para preparar didesoxiinosina usando enzima de adenosina desaminasa. - Google Patents

Proceso para preparar didesoxiinosina usando enzima de adenosina desaminasa.

Info

Publication number
MXPA05009261A
MXPA05009261A MXPA05009261A MXPA05009261A MXPA05009261A MX PA05009261 A MXPA05009261 A MX PA05009261A MX PA05009261 A MXPA05009261 A MX PA05009261A MX PA05009261 A MXPA05009261 A MX PA05009261A MX PA05009261 A MXPA05009261 A MX PA05009261A
Authority
MX
Mexico
Prior art keywords
ddi
enzyme
dda
solution
dideoxyinosine
Prior art date
Application number
MXPA05009261A
Other languages
English (en)
Inventor
L Anderson Wendy
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MXPA05009261A publication Critical patent/MXPA05009261A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invencion se refiere a un metodo para elaborar didanosina (ddI) que incluye las etapas de: (a) obtener una enzima que expresa actividad desaminasa ddA; (b) inmovilizar la enzima en un soporte insoluble; (c) poner en contacto la enzima con una solucion de didesoxiadenosina (ddA) por al menos aproximadamente 4% en peso de volumen de ddA en agua, por un tiempo y bajo condiciones para producir una solucion de ddI; y (d) aislar la ddI de la solucion de ddI. Opcionalmente, el licor madre de ddI es reutilizado en corridas subsecuentes para mejorar el rendimiento.
MXPA05009261A 2003-03-04 2004-02-27 Proceso para preparar didesoxiinosina usando enzima de adenosina desaminasa. MXPA05009261A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45184203P 2003-03-04 2003-03-04
PCT/US2004/006103 WO2004078993A2 (en) 2003-03-04 2004-02-27 Process for preparing dideoxyinosine using adenosine deaminase enzyme

Publications (1)

Publication Number Publication Date
MXPA05009261A true MXPA05009261A (es) 2005-10-19

Family

ID=32962647

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05009261A MXPA05009261A (es) 2003-03-04 2004-02-27 Proceso para preparar didesoxiinosina usando enzima de adenosina desaminasa.

Country Status (12)

Country Link
US (1) US20040175804A1 (es)
EP (1) EP1618204A4 (es)
JP (1) JP2007525163A (es)
KR (1) KR20050109956A (es)
CN (1) CN1954080A (es)
AU (1) AU2004217521A1 (es)
BR (1) BRPI0407959A (es)
CA (1) CA2517674A1 (es)
MX (1) MXPA05009261A (es)
PL (1) PL381265A1 (es)
TW (1) TW200506062A (es)
WO (1) WO2004078993A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5595904B2 (ja) * 2007-04-20 2014-09-24 シグマ−タウ レア ディジージズ エスィアー 酵素による抗癌治療
US8624217B2 (en) 2010-06-25 2014-01-07 International Business Machines Corporation Planar phase-change memory cell with parallel electrical paths
US8575008B2 (en) 2010-08-31 2013-11-05 International Business Machines Corporation Post-fabrication self-aligned initialization of integrated devices
CN103451255B (zh) * 2013-03-28 2016-03-16 南京工业大学 次黄嘌呤核苷酸的生产方法
CN107974476B (zh) * 2018-01-10 2020-12-29 中国科学院沈阳应用生态研究所 一种虫草素转化为3’-脱氧肌苷的生物转化方法
CN111921505B (zh) * 2020-08-06 2022-08-09 同济大学 邻二醇功能化大孔通孔材料及其制备方法和硼酸吸附应用
CN118215490A (zh) * 2021-08-30 2024-06-18 小利兰·斯坦福大学董事会 具有腺苷脱氨酶的细胞表面表达的t细胞及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4835104A (en) * 1987-06-16 1989-05-30 Ajinomoto Co., Inc., Patent & Licensing Department Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides
US5011774A (en) * 1987-07-17 1991-04-30 Bristol-Myers Squibb Co. Dideoxyinosine by enzymatic deamination of dideoxyadenosine
JPH0757198B2 (ja) * 1987-10-07 1995-06-21 味の素株式会社 ジデオキシイノシンの製造方法
US6010853A (en) * 1997-05-29 2000-01-04 Dana-Farber Cancer Institute Siva genes, novel genes involved in CD27-mediated apoptosis
US6068991A (en) * 1997-12-16 2000-05-30 Bristol-Myers Squibb Company High expression Escherichia coli expression vector
US6359145B1 (en) * 1998-07-23 2002-03-19 Fujisawa Pharmaceutical Co., Ltd. Imidazole compounds
US20020156259A1 (en) * 2000-08-15 2002-10-24 Conklin Darrell C. Human adenosine deaminase

Also Published As

Publication number Publication date
AU2004217521A1 (en) 2004-09-16
CA2517674A1 (en) 2004-09-16
WO2004078993A3 (en) 2006-10-05
TW200506062A (en) 2005-02-16
KR20050109956A (ko) 2005-11-22
JP2007525163A (ja) 2007-09-06
BRPI0407959A (pt) 2006-03-07
EP1618204A4 (en) 2007-05-30
PL381265A1 (pl) 2007-05-14
US20040175804A1 (en) 2004-09-09
EP1618204A2 (en) 2006-01-25
CN1954080A (zh) 2007-04-25
WO2004078993A2 (en) 2004-09-16

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