MXPA05003713A - Metodo de purificacion de lantibioticos. - Google Patents

Metodo de purificacion de lantibioticos.

Info

Publication number
MXPA05003713A
MXPA05003713A MXPA05003713A MXPA05003713A MXPA05003713A MX PA05003713 A MXPA05003713 A MX PA05003713A MX PA05003713 A MXPA05003713 A MX PA05003713A MX PA05003713 A MXPA05003713 A MX PA05003713A MX PA05003713 A MXPA05003713 A MX PA05003713A
Authority
MX
Mexico
Prior art keywords
lantibiotic
lantibiotics
purifying
solution containing
disclosed
Prior art date
Application number
MXPA05003713A
Other languages
English (en)
Inventor
H Crabb Joseph
Original Assignee
Immucell Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immucell Corp filed Critical Immucell Corp
Publication of MXPA05003713A publication Critical patent/MXPA05003713A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Se describe un metodo para purificar un lantibiotico a partir de una solucion bruta o parcialmente purificada que contiene el lantibiotico. En realizaciones preferidas, el lantibiotico es nisina, aunque las caracteristicas estructurales comunes de los lantibioticos dictan la efectividad de los metodos de purificacion descritos para otros miembros del genero lantibiotico. El metodo incluye la etapa de formacion de una mezcla de incubacion consistente en la solucion que contiene el lantibiotico y una enzima proteolitica y de incubacion de la mezcla en condiciones optimizadas para la actividad proteolitica selectiva.
MXPA05003713A 2002-10-09 2003-10-07 Metodo de purificacion de lantibioticos. MXPA05003713A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/268,037 US6794181B2 (en) 2002-10-09 2002-10-09 Method of purifying lantibiotics
PCT/US2003/031986 WO2004033704A1 (en) 2002-10-09 2003-10-07 Method of purifying lantibiotics

Publications (1)

Publication Number Publication Date
MXPA05003713A true MXPA05003713A (es) 2005-09-30

Family

ID=32068478

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05003713A MXPA05003713A (es) 2002-10-09 2003-10-07 Metodo de purificacion de lantibioticos.

Country Status (12)

Country Link
US (1) US6794181B2 (es)
EP (1) EP1549757A4 (es)
JP (1) JP2006501854A (es)
KR (1) KR20050072433A (es)
CN (1) CN1703518A (es)
AU (1) AU2003279208A1 (es)
BR (1) BR0315219A (es)
CA (1) CA2501635A1 (es)
CR (1) CR7783A (es)
MX (1) MXPA05003713A (es)
WO (1) WO2004033704A1 (es)
ZA (1) ZA200502822B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101363007A (zh) * 2003-11-07 2009-02-11 味之素株式会社 能产生耐蛋白酶细菌素的乳酸菌及其培养物
US20090215985A1 (en) * 2005-08-12 2009-08-27 Oragenics, Inc. Differentially protected orthogonal lanthionine technology
NZ566546A (en) * 2005-08-12 2011-01-28 Oragenics Inc Differentially protected orthogonal lanthionine technology
BRPI0707782A2 (pt) * 2006-02-13 2011-05-10 Boehringer Ingelheim Vetmed processo para a fabricaÇço de lantibiàticos
US20100041613A1 (en) 2006-03-09 2010-02-18 John Coleman Novel antibiotic compositions
EP2267003A1 (en) * 2009-06-24 2010-12-29 Applied NanoSystems B.V. Biologically produced cyclic affinity tags
EP2799068A1 (en) 2013-05-01 2014-11-05 National University of Ireland, Galway Antimicrobial compositions and methods for their production
US10023617B1 (en) * 2018-01-11 2018-07-17 Immucell Corporation Methods and systems of producing pharmaceutical grade lantibiotics

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4900677A (en) * 1986-09-26 1990-02-13 E. I. Du Pont De Nemours And Company Process for rapid isolation of high molecular weight DNA
JP2794305B2 (ja) * 1988-07-20 1998-09-03 明治乳業株式会社 牛乳乳清蛋白質中のβ―ラクトログロブリンの選択的酵素分解方法
JPH0724578B2 (ja) * 1990-09-17 1995-03-22 雪印乳業株式会社 ナイシン生産性微生物及びそれを使用するナイシンの生産方法
GB2254852B (en) * 1991-04-11 1995-04-05 Thomae Gmbh Dr K Lantibiotic isolation and purification by plural chromatography processes
US5451369A (en) * 1992-05-13 1995-09-19 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Bacteriocidal surfaces and articles with attached bacteriocin
JP3112597B2 (ja) * 1993-03-16 2000-11-27 雪印乳業株式会社 低アレルゲン性乳蛋白質の製造法
US5650320A (en) * 1994-04-20 1997-07-22 University Of Alabama At Birmingham Research Foundation Lanthionine antibiotic compositions and methods
JP3364551B2 (ja) * 1995-03-03 2003-01-08 天野エンザイム株式会社 低アレルゲン性乳蛋白質の製造法
US5804684A (en) * 1995-08-24 1998-09-08 The Theobald Smith Research Institute, Inc. Method for isolating nucleic acids
JP3289770B2 (ja) * 1996-03-28 2002-06-10 不二製油株式会社 蛋白分解物及びその製造方法
JP3269519B2 (ja) * 1996-03-28 2002-03-25 不二製油株式会社 大豆蛋白分解物及びその製造方法
JPH1156250A (ja) * 1997-08-27 1999-03-02 Fuji Oil Co Ltd 蛋白分解物及びその製造方法

Also Published As

Publication number Publication date
CN1703518A (zh) 2005-11-30
ZA200502822B (en) 2006-11-29
KR20050072433A (ko) 2005-07-11
CR7783A (es) 2005-10-05
BR0315219A (pt) 2005-08-23
EP1549757A4 (en) 2006-03-15
JP2006501854A (ja) 2006-01-19
EP1549757A1 (en) 2005-07-06
US6794181B2 (en) 2004-09-21
CA2501635A1 (en) 2004-04-22
WO2004033704A1 (en) 2004-04-22
AU2003279208A1 (en) 2004-05-04
US20040072333A1 (en) 2004-04-15

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