MXPA04005554A - Benzotiazoles. - Google Patents
Benzotiazoles.Info
- Publication number
- MXPA04005554A MXPA04005554A MXPA04005554A MXPA04005554A MXPA04005554A MX PA04005554 A MXPA04005554 A MX PA04005554A MX PA04005554 A MXPA04005554 A MX PA04005554A MX PA04005554 A MXPA04005554 A MX PA04005554A MX PA04005554 A MXPA04005554 A MX PA04005554A
- Authority
- MX
- Mexico
- Prior art keywords
- lower alkyl
- optionally substituted
- pyran
- dihydro
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/84—Naphthothiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
La presente invencion se refiere a compuestos de formula general (I), en la que R1 es el 3,6-dihidro-2H-piran-4-ilo, el 5,6-dihidro-4H-piran-3-ilo, el 5,6-dihidro-4H-piran-2-ilo, el tetrahidropiran-2-, -3- o -4-ilo, el ciclohex-2-enilo, el ciclohexilo o es el 1,2,3,6, tetrahidropiridi-4-ilo o piperidin-4-ilo, que estan opcionalmente sustituidos por C(O)CH3 en la posicion 2 del atomo de hidroxi o es fenil, opcionalmente sustituido por N; R2 es alquilo de bajo peso molecular, piperidin-1-ilo opcionalmente sustituido por -(CH2)n-N(R`)-C(O)- -(CH2)n-NR2`, -(CH2)n -o-alquilo de bajo peso molecular; o es morfolinilo o es piridinilo que esta opcionalmente sustituido por halogeno, -N(R`)- -(CH2)n-O-alquilo de bajo peso molecular, morfolinilo opcionalmente sustituido por halogeno. -NR1) -(CH2)n-O- alquilo inferior, alquilo inferior, alcoxi inferior, morofolinilo o -(CH2)n- pirrolidinilo; n es el numero 0, 1 o 2; R` es hidrogeno o alquilo de bajo peso molecular, y a sales de adicion de acido farmaceuticamente aceptables de los mismos. se ha constatado que los compuestos de la formula general I son ligandos del receptor de adenosina. De modo especifico, los compuestos de la presente invencion tienen buena afinidad con el receptor A2A y pueden utilizarse para el tratamiento de enfermedades relacionadas con este receptor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01129273 | 2001-12-12 | ||
| PCT/EP2002/013769 WO2003053961A1 (en) | 2001-12-12 | 2002-12-05 | Benzothiazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04005554A true MXPA04005554A (es) | 2004-09-10 |
Family
ID=8179487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04005554A MXPA04005554A (es) | 2001-12-12 | 2002-12-05 | Benzotiazoles. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6734179B2 (es) |
| EP (1) | EP1456202B1 (es) |
| JP (1) | JP4283116B2 (es) |
| KR (1) | KR100582696B1 (es) |
| CN (1) | CN1286834C (es) |
| AR (1) | AR037792A1 (es) |
| AT (1) | ATE309242T1 (es) |
| AU (1) | AU2002356628B2 (es) |
| BR (1) | BR0214837A (es) |
| CA (1) | CA2469876C (es) |
| DE (1) | DE60207294T2 (es) |
| ES (1) | ES2251628T3 (es) |
| GT (1) | GT200200270A (es) |
| MX (1) | MXPA04005554A (es) |
| PA (1) | PA8561101A1 (es) |
| PE (1) | PE20030751A1 (es) |
| PL (1) | PL371064A1 (es) |
| RU (1) | RU2293736C2 (es) |
| TW (1) | TW200409772A (es) |
| UY (1) | UY27578A1 (es) |
| WO (1) | WO2003053961A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1587799B1 (en) * | 2003-01-13 | 2008-03-12 | F. Hoffmann-La Roche Ag | Benzoxazole derivatives and their use as adenosine receptor ligands |
| US6872833B2 (en) * | 2003-04-14 | 2005-03-29 | Hoffmann-La Roche Inc. | Adenosine receptor ligands |
| RU2351597C2 (ru) * | 2003-05-19 | 2009-04-10 | Ф.Хоффманн-Ля Рош Аг | Производные бензотиазола в качестве лигандов аденозиновых рецепторов |
| ATE353648T1 (de) * | 2003-05-21 | 2007-03-15 | Hoffmann La Roche | Benzothiazole derivate und ihre anwendung in der behandlung von adenosine a2a rezeptor vermittelte krankheiten |
| JP2007505851A (ja) * | 2003-09-19 | 2007-03-15 | エフ．ホフマン−ラ ロシュ アーゲー | アデノシン受容体リガンドとしてのチアゾピリジン誘導体 |
| TWI370820B (en) | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
| WO2008052930A2 (en) * | 2006-11-03 | 2008-05-08 | F. Hoffmann-La Roche Ag | Preparation of 4-alk0xy-7- (tetrahydropyran-4-yl) benzothiazol-2-amine derivatives |
| DE102011005232A1 (de) | 2011-03-08 | 2012-09-13 | AristoCon GmbH & Co. KG | Adenosin und seine Derivate zur Verwendung in der Schmerztherapie |
| AR117844A1 (es) * | 2019-01-22 | 2021-09-01 | Merck Patent Gmbh | Derivados de tiazolopiridina como antagonistas del receptor de adenosina |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0113219B1 (en) | 1982-12-21 | 1987-11-19 | Johnsen & Jorgensen (Plastics) Limited | Dispensing container |
| RU2212407C2 (ru) | 1997-11-10 | 2003-09-20 | Бристол-Маерс Сквибб Компани | Бензотиазольные ингибиторы протеинтирозинкиназ |
| EA200100265A1 (ru) | 1998-09-22 | 2001-10-22 | Киова Хакко Когио Ко., Лтд. | Производные [1,2,4]триазоло[1,5-c]пиримидина |
| CZ2003182A3 (cs) * | 2000-06-21 | 2003-06-18 | F. Hoffmann-La Roche Ag | Deriváty benzothiazolu |
| US6620811B2 (en) * | 2001-11-19 | 2003-09-16 | Hoffmann-La Roche Inc. | Isonicotin- and nicotinamide derivatives of benzothiazoles |
| US6713499B2 (en) * | 2001-12-12 | 2004-03-30 | Hoffman-La Roche Inc. | 7-Amino-benzothiazole derivatives |
-
2002
- 2002-12-02 US US10/307,698 patent/US6734179B2/en not_active Expired - Fee Related
- 2002-12-05 DE DE60207294T patent/DE60207294T2/de not_active Expired - Lifetime
- 2002-12-05 AU AU2002356628A patent/AU2002356628B2/en not_active Ceased
- 2002-12-05 WO PCT/EP2002/013769 patent/WO2003053961A1/en active IP Right Grant
- 2002-12-05 BR BR0214837-4A patent/BR0214837A/pt not_active Application Discontinuation
- 2002-12-05 CA CA2469876A patent/CA2469876C/en not_active Expired - Fee Related
- 2002-12-05 MX MXPA04005554A patent/MXPA04005554A/es active IP Right Grant
- 2002-12-05 KR KR1020047008941A patent/KR100582696B1/ko not_active IP Right Cessation
- 2002-12-05 AT AT02805304T patent/ATE309242T1/de active
- 2002-12-05 RU RU2004121683/04A patent/RU2293736C2/ru not_active IP Right Cessation
- 2002-12-05 JP JP2003554677A patent/JP4283116B2/ja not_active Expired - Fee Related
- 2002-12-05 CN CNB028248481A patent/CN1286834C/zh not_active Expired - Fee Related
- 2002-12-05 EP EP02805304A patent/EP1456202B1/en not_active Expired - Lifetime
- 2002-12-05 PL PL02371064A patent/PL371064A1/xx not_active Application Discontinuation
- 2002-12-05 ES ES02805304T patent/ES2251628T3/es not_active Expired - Lifetime
- 2002-12-09 TW TW091135553A patent/TW200409772A/zh unknown
- 2002-12-10 PA PA20028561101A patent/PA8561101A1/es unknown
- 2002-12-10 PE PE2002001189A patent/PE20030751A1/es not_active Application Discontinuation
- 2002-12-11 GT GT200200270A patent/GT200200270A/es unknown
- 2002-12-11 AR ARP020104800A patent/AR037792A1/es unknown
- 2002-12-11 UY UY27578A patent/UY27578A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2293736C2 (ru) | 2007-02-20 |
| JP4283116B2 (ja) | 2009-06-24 |
| AU2002356628A1 (en) | 2003-07-09 |
| EP1456202B1 (en) | 2005-11-09 |
| RU2004121683A (ru) | 2006-01-10 |
| ES2251628T3 (es) | 2006-05-01 |
| AU2002356628B2 (en) | 2008-04-17 |
| WO2003053961A1 (en) | 2003-07-03 |
| JP2005521647A (ja) | 2005-07-21 |
| CN1286834C (zh) | 2006-11-29 |
| ATE309242T1 (de) | 2005-11-15 |
| TW200409772A (en) | 2004-06-16 |
| BR0214837A (pt) | 2004-08-31 |
| US6734179B2 (en) | 2004-05-11 |
| CN1602310A (zh) | 2005-03-30 |
| CA2469876A1 (en) | 2003-07-03 |
| PL371064A1 (en) | 2005-06-13 |
| PA8561101A1 (es) | 2003-07-28 |
| DE60207294D1 (en) | 2005-12-15 |
| UY27578A1 (es) | 2003-06-30 |
| CA2469876C (en) | 2011-01-11 |
| AR037792A1 (es) | 2004-12-01 |
| GT200200270A (es) | 2003-07-30 |
| EP1456202A1 (en) | 2004-09-15 |
| KR100582696B1 (ko) | 2006-05-23 |
| PE20030751A1 (es) | 2003-09-05 |
| DE60207294T2 (de) | 2006-07-20 |
| US20030144288A1 (en) | 2003-07-31 |
| KR20040073473A (ko) | 2004-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |