MXPA04005176A - N-ureido-piperidinas como antagonistas viii para receptores ccr-3. - Google Patents

N-ureido-piperidinas como antagonistas viii para receptores ccr-3.

Info

Publication number
MXPA04005176A
MXPA04005176A MXPA04005176A MXPA04005176A MXPA04005176A MX PA04005176 A MXPA04005176 A MX PA04005176A MX PA04005176 A MXPA04005176 A MX PA04005176A MX PA04005176 A MXPA04005176 A MX PA04005176A MX PA04005176 A MXPA04005176 A MX PA04005176A
Authority
MX
Mexico
Prior art keywords
ccr
antagonists
receptor
piperidines
ureido
Prior art date
Application number
MXPA04005176A
Other languages
English (en)
Inventor
Wang Beihan
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MXPA04005176A publication Critical patent/MXPA04005176A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invencion se refiere a compuestos de Formula (I):(ver formula I)en la cual R1-R5, A, L y X son tal como se han definido en la descripcion. Los compuestos son utiles como antagonistas del receptor CCR-3 y, por lo tanto, pueden utilizarse en el tratamiento de enfermedades mediadas por CCR-3.
MXPA04005176A 2001-11-30 2002-11-25 N-ureido-piperidinas como antagonistas viii para receptores ccr-3. MXPA04005176A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33465301P 2001-11-30 2001-11-30
PCT/EP2002/013218 WO2003045937A1 (en) 2001-11-30 2002-11-25 N-ureido-piperidines as antagonists viii for ccr-3 receptor

Publications (1)

Publication Number Publication Date
MXPA04005176A true MXPA04005176A (es) 2004-08-11

Family

ID=23308166

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04005176A MXPA04005176A (es) 2001-11-30 2002-11-25 N-ureido-piperidinas como antagonistas viii para receptores ccr-3.

Country Status (12)

Country Link
EP (1) EP1453825A1 (es)
JP (1) JP2005515193A (es)
KR (1) KR100652450B1 (es)
CN (1) CN1286831C (es)
AR (1) AR037458A1 (es)
AU (1) AU2002352123A1 (es)
BR (1) BR0214613A (es)
CA (1) CA2467874A1 (es)
MX (1) MXPA04005176A (es)
PL (1) PL370821A1 (es)
RU (1) RU2004120064A (es)
WO (1) WO2003045937A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006508948A (ja) * 2002-10-30 2006-03-16 メルク　エンド　カムパニー　インコーポレーテッド ケモカイン受容体活性のヘテロアリールピペリジンモジュレーター
JP4384635B2 (ja) * 2003-06-30 2009-12-16 住友化学株式会社 不斉尿素化合物およびこれを触媒として用いる不斉共役付加反応による不斉化合物の製造方法
JP4463209B2 (ja) * 2003-12-17 2010-05-19 住友化学株式会社 光学活性アミン化合物の製造方法
WO2006071958A1 (en) 2004-12-29 2006-07-06 Millennium Pharmaceuticals, Inc. Compounds useful as chemokine receptor antagonists
WO2006071875A1 (en) 2004-12-29 2006-07-06 Millennium Pharmaceuticals, Inc. Compounds useful as chemokine receptor antagonists
EP2805985A1 (de) * 2013-05-22 2014-11-26 Sika Technology AG Hydroxysilan und Silangruppen-haltiges Polymer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200101859T2 (tr) * 1998-12-18 2001-12-21 Dupont Pharmaceuticals Company Kemokin alıcı aktivitesinin modülatörleri olarak N-üreidoalkil-piperidinler

Also Published As

Publication number Publication date
CN1286831C (zh) 2006-11-29
CA2467874A1 (en) 2003-06-05
EP1453825A1 (en) 2004-09-08
BR0214613A (pt) 2004-09-14
KR100652450B1 (ko) 2007-02-28
JP2005515193A (ja) 2005-05-26
CN1599733A (zh) 2005-03-23
PL370821A1 (en) 2005-05-30
AU2002352123A1 (en) 2003-06-10
KR20040062665A (ko) 2004-07-07
WO2003045937A1 (en) 2003-06-05
RU2004120064A (ru) 2006-01-10
AR037458A1 (es) 2004-11-10

Similar Documents

Publication Publication Date Title
MY135841A (en) Novel benzodioxoles
YU63703A (sh) 6-supstituisani pirido-pirimidini
AU2002319814A1 (en) Substituted 1h-dihydropyrazoles, their preparation and use
HK1083505A1 (en) Ccr5 antagonists useful for treating aids
BG108660A (en) Pyrrolidinone derivatives
TW200510325A (en) 2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof
GB0426313D0 (en) Therapeutic agents
MXPA05007115A (es) Nuevos agonistas inversos del receptor cb 1.
IS8377A (is) Arýlindenópyridín og arýlindenópyrimidín og notkun þeirra sem mótlyf A2A viðtaka adenósíns
WO2003106450A8 (de) Phenylaminopyrimidine und ihre verwendung als rho-kinase inhibitoren
PL371127A1 (en) 6-aminomorphinane derivatives, method for the production and use thereof
MXPA05009014A (es) Antagonistas del receptor ccr-3.
MY141011A (en) Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
MXPA04007391A (es) Heterociclos triciclicos fusionados utiles para el tratamiento de padecimientos hiper-proliferantes.
MXPA04004981A (es) Derivados de piperazina para uso como antagonistas del receptor ccr-3 en tratamiento de asma.
GB0322510D0 (en) Novel compounds
GB0320320D0 (en) Novel compounds
SE0200844D0 (sv) Chemical compounds
AU2001290480A1 (en) Cyclized benzamide neurokinin antagonists for use in therapy
AU2003212769A1 (en) Piperidine derivatives useful as modulators of chemokine receptor activity
MY135396A (en) Chemical compounds
MXPA04003544A (es) Benzotriazepinas como ligandos del receptor de gastrina y colecistocinina.
MXPA04005176A (es) N-ureido-piperidinas como antagonistas viii para receptores ccr-3.
MXPA04004980A (es) Antagonistas del receptor ccr-3.
MXPA04005151A (es) Compuestos terapeuticos.

Legal Events

Date Code Title Description
FG Grant or registration