MXPA02005476A - Derivados de benzo(a)fenacin-11-carboxamidas y su uso como inhibidores de topoisomerasa i y ii. - Google Patents

Derivados de benzo(a)fenacin-11-carboxamidas y su uso como inhibidores de topoisomerasa i y ii.

Info

Publication number
MXPA02005476A
MXPA02005476A MXPA02005476A MXPA02005476A MXPA02005476A MX PA02005476 A MXPA02005476 A MX PA02005476A MX PA02005476 A MXPA02005476 A MX PA02005476A MX PA02005476 A MXPA02005476 A MX PA02005476A MX PA02005476 A MXPA02005476 A MX PA02005476A
Authority
MX
Mexico
Prior art keywords
topomerase
phenazin
benzo
carboxamide derivatives
inhibitors
Prior art date
Application number
MXPA02005476A
Other languages
English (en)
Spanish (es)
Inventor
Milton John
Original Assignee
Xenova Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Ltd filed Critical Xenova Ltd
Publication of MXPA02005476A publication Critical patent/MXPA02005476A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/46—Phenazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MXPA02005476A 1999-12-02 2000-12-01 Derivados de benzo(a)fenacin-11-carboxamidas y su uso como inhibidores de topoisomerasa i y ii. MXPA02005476A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9928542.1A GB9928542D0 (en) 1999-12-02 1999-12-02 Pharmaceutical compounds
PCT/GB2000/004609 WO2001046157A1 (en) 1999-12-02 2000-12-01 Benzo[a]phenazin-11-carboxamide derivatives and their use as joint inhibitors of topomerase i and ii

Publications (1)

Publication Number Publication Date
MXPA02005476A true MXPA02005476A (es) 2003-09-22

Family

ID=10865607

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02005476A MXPA02005476A (es) 1999-12-02 2000-12-01 Derivados de benzo(a)fenacin-11-carboxamidas y su uso como inhibidores de topoisomerasa i y ii.

Country Status (16)

Country Link
EP (1) EP1240148A1 (ja)
JP (1) JP2003518103A (ja)
KR (1) KR100767613B1 (ja)
CN (1) CN1304380C (ja)
AU (1) AU784397B2 (ja)
BR (1) BR0016093A (ja)
CA (1) CA2392873A1 (ja)
GB (2) GB9928542D0 (ja)
HK (1) HK1046133B (ja)
HU (1) HUP0300392A3 (ja)
MX (1) MXPA02005476A (ja)
MY (1) MY136029A (ja)
PL (1) PL356482A1 (ja)
TW (1) TWI280242B (ja)
WO (1) WO2001046157A1 (ja)
ZA (1) ZA200204296B (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2433071A (en) * 2005-12-05 2007-06-13 Kontrakt Technology Ltd Organic acids comprising planar conjugated heterocyclic molecular system, & photoelectric layer thereof with rodlike supramolecules for use in solar cell
CN102898388B (zh) * 2012-09-26 2014-12-03 浙江工业大学 一种合成取代苯并[α]吩嗪类化合物的方法
CN103360329B (zh) * 2013-07-18 2015-11-18 中国科学院南海海洋研究所 一类吩嗪化合物及其在制备抗肿瘤药物中的应用
CN106554321B (zh) * 2015-09-25 2019-05-28 陆源 一种吩嗪类物质、其制备方法及其应用
CN113461623A (zh) * 2021-07-14 2021-10-01 长江大学 一种抗病毒化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69329336D1 (de) * 1992-05-28 2000-10-05 Xenova Ltd Acridin carboxamide zur behandlung von krebs
US5696131A (en) * 1993-01-22 1997-12-09 Xenova Limited Treatment of cancers
CA2266321A1 (en) * 1996-09-23 1998-03-26 Rutgers, The State University Of New Jersey Substituted heterocycles as anti-tumor agents
WO1998045272A1 (en) * 1997-04-07 1998-10-15 Latrobe University Topoisomerase inhibitors

Also Published As

Publication number Publication date
HK1046133B (zh) 2005-04-15
GB0215275D0 (en) 2002-08-14
GB2373499A (en) 2002-09-25
TWI280242B (en) 2007-05-01
CA2392873A1 (en) 2001-06-28
WO2001046157A1 (en) 2001-06-28
JP2003518103A (ja) 2003-06-03
AU1718401A (en) 2001-07-03
BR0016093A (pt) 2002-08-20
KR100767613B1 (ko) 2007-10-19
HK1046133A1 (en) 2002-12-27
PL356482A1 (en) 2004-06-28
KR20020070305A (ko) 2002-09-05
HUP0300392A2 (hu) 2003-07-28
CN1433406A (zh) 2003-07-30
HUP0300392A3 (en) 2003-09-29
GB9928542D0 (en) 2000-02-02
EP1240148A1 (en) 2002-09-18
ZA200204296B (en) 2003-05-29
MY136029A (en) 2008-07-31
CN1304380C (zh) 2007-03-14
AU784397B2 (en) 2006-03-23
GB2373499B (en) 2004-11-17

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal