MXPA02002538A - T2r, una nueva familia de receptores del gusto. - Google Patents

T2r, una nueva familia de receptores del gusto.

Info

Publication number
MXPA02002538A
MXPA02002538A MXPA02002538A MXPA02002538A MXPA02002538A MX PA02002538 A MXPA02002538 A MX PA02002538A MX PA02002538 A MXPA02002538 A MX PA02002538A MX PA02002538 A MXPA02002538 A MX PA02002538A MX PA02002538 A MXPA02002538 A MX PA02002538A
Authority
MX
Mexico
Prior art keywords
seq
receptor
polypeptide
nucleic acid
protein
Prior art date
Application number
MXPA02002538A
Other languages
English (en)
Spanish (es)
Inventor
Ken Mueller
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/393,634 external-priority patent/US6558910B2/en
Application filed by Univ California filed Critical Univ California
Publication of MXPA02002538A publication Critical patent/MXPA02002538A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
MXPA02002538A 1999-09-10 2000-09-08 T2r, una nueva familia de receptores del gusto. MXPA02002538A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/393,634 US6558910B2 (en) 1999-09-10 1999-09-10 SF, a novel family of taste receptors
US09/510,332 US7244584B2 (en) 1999-09-10 2000-02-22 T2R, a novel family of taste receptors
PCT/US2000/024821 WO2001018050A2 (en) 1999-09-10 2000-09-08 T2r taste receptor family

Publications (1)

Publication Number Publication Date
MXPA02002538A true MXPA02002538A (es) 2005-07-01

Family

ID=27014384

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02002538A MXPA02002538A (es) 1999-09-10 2000-09-08 T2r, una nueva familia de receptores del gusto.

Country Status (10)

Country Link
US (8) US7465550B2 (https=)
EP (1) EP1214343A2 (https=)
JP (1) JP4339542B2 (https=)
CN (1) CN1289525C (https=)
AU (2) AU773600B2 (https=)
CA (1) CA2384777A1 (https=)
IL (1) IL148593A0 (https=)
MX (1) MXPA02002538A (https=)
NO (1) NO20021164L (https=)
WO (1) WO2001018050A2 (https=)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558910B2 (en) 1999-09-10 2003-05-06 The Regents Of The University Of California SF, a novel family of taste receptors
EP1214343A2 (en) 1999-09-10 2002-06-19 The Regents Of The University Of California T2r taste receptor family
TW201006846A (en) * 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
AU2001251258B2 (en) 2000-04-07 2008-06-05 Senomyx, Inc. T2r taste receptors and genes encoding same
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US20080244761A1 (en) 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US8030008B2 (en) 2001-04-05 2011-10-04 Senomyx, Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
AU2002326315B2 (en) 2001-06-26 2007-07-05 Senomyx, Inc. T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
CA2452337A1 (en) * 2001-07-10 2003-01-23 Senomyx, Inc. Use of specific t2r taste receptors to identify compounds that block bitter taste
AU2002326429B2 (en) * 2001-07-20 2007-09-20 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Phenylthiocarbamide (PTC) taste receptor
US20070059688A1 (en) * 2001-10-12 2007-03-15 Rozengurt Juan E Gastrointestinal chemosensory receptors
WO2004011617A2 (en) 2002-07-29 2004-02-05 Senomyx, Inc. Identification of a novel bitter taste receptor, t2r76
EP2267129B1 (en) * 2002-09-25 2015-03-25 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Bitter taste receptors
DE60320682T2 (de) 2002-12-18 2009-06-10 Givaudan S.A. Chimäre alpha q-gustducin g-proteine
EP1644528A2 (en) 2003-06-19 2006-04-12 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, Variants of human taste receptor genes
WO2006053771A2 (en) 2004-11-18 2006-05-26 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Stiftung Des Öffentlichen Rechts Agonists of bitter taste receptors and uses thereof
MX2007009497A (es) 2005-02-08 2008-01-18 Senomyx Inc Receptores t2r humanos para acetaminofen, ranitidina, estricnina y denatonio, y ensayos relacionados para identificar moduladores de sabor amargo humanos.
US8017336B2 (en) 2005-12-27 2011-09-13 Nihon University Method of examining zinc-deficient taste disturbance by determining expression level of taste receptor genes
JP2009533065A (ja) 2006-04-20 2009-09-17 ジボダン エス エー 味覚物質同定のための機能的方法
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
WO2007121604A2 (en) 2006-04-20 2007-11-01 Givaudan Sa Method relating to sweetness enhancement
WO2008030429A2 (en) * 2006-09-05 2008-03-13 Senomyx, Inc. Novel haplotype of human t2r receptor ht2r50 and its use in assays for identifying human bitter taste modulators
WO2008086634A2 (en) 2007-01-18 2008-07-24 Givaudan Sa Chimeric umami taste receptor, nucleic acid encoding it and use thereof
KR20100016044A (ko) 2007-03-30 2010-02-12 지보당 에스아 조절제의 동정 방법
CA2691906A1 (en) * 2007-06-08 2009-01-15 Senomyx, Inc. Identification of trpml3 (mcoln3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone and/or vasopressin production or release
KR101558193B1 (ko) 2007-08-21 2015-10-12 세노믹스, 인코포레이티드 인간 ｔ2ｒ 쓴맛 수용체 및 이의 용도
EP2245171A2 (en) * 2008-02-01 2010-11-03 Chromocell Corporation Cell lines and methods for making and using them
EP2567231A1 (en) 2010-05-07 2013-03-13 Givaudan SA Methods to identify modulators of tas2r4s receptors
US20130115624A1 (en) 2010-05-07 2013-05-09 Givaudan S.A. Methods To Identify Modulators
CN103068380A (zh) * 2010-06-17 2013-04-24 加州理工学院 用于调节激素的方法和系统以及相关的方法、剂和组合物
EP2742350B1 (en) 2011-08-08 2019-10-30 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
WO2013159227A1 (en) * 2012-04-25 2013-10-31 University Of Manitoba Bitter taste receptor constitutively active mutants
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
JP6461901B2 (ja) 2013-03-15 2019-01-30 アプライド フード バイオテクノロジー インコーポレーテッド ネコ科苦味受容体及び方法
US9169311B2 (en) 2013-03-15 2015-10-27 Applied Food Biotechnology, Inc. Feline bitter taste receptors and methods
CN105339384A (zh) 2013-05-10 2016-02-17 百事可乐公司 作为鉴别潜在味觉调节剂的模型的细胞
HK1218302A1 (zh) * 2013-05-10 2017-02-10 百事可乐公司 味觉感受器内化试验
EP3104712B1 (en) 2014-02-12 2020-05-06 Firmenich Incorporated Improved process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones

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WO1993016178A2 (en) 1992-02-12 1993-08-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sequences characteristic of human gene transcription product
WO1998013478A2 (en) 1996-09-04 1998-04-02 Mogen International N.V. Antifungal proteins, dna coding therefore, and hosts incorporating same
EP1056764A4 (en) 1998-02-18 2001-08-29 Genetics Inst SECRETED PROTEINS AND POLYNUCLEOTIDES ENCODING SAID PROTEINS
CA2356533C (en) 1998-12-23 2010-07-13 Mount Sinai School Of Medicine Inhibitors of the bitter taste response
EP1214343A2 (en) 1999-09-10 2002-06-19 The Regents Of The University Of California T2r taste receptor family
US6558910B2 (en) 1999-09-10 2003-05-06 The Regents Of The University Of California SF, a novel family of taste receptors

Also Published As

Publication number Publication date
NO20021164D0 (no) 2002-03-08
WO2001018050A2 (en) 2001-03-15
US7465550B2 (en) 2008-12-16
JP4339542B2 (ja) 2009-10-07
CN1289525C (zh) 2006-12-13
US9063124B2 (en) 2015-06-23
AU7366400A (en) 2001-04-10
IL148593A0 (en) 2002-09-12
US7595166B2 (en) 2009-09-29
CA2384777A1 (en) 2001-03-15
AU773600B2 (en) 2004-05-27
AU2004203826A1 (en) 2004-09-16
US8624012B2 (en) 2014-01-07
US20120009598A1 (en) 2012-01-12
US20150260733A1 (en) 2015-09-17
US20180128842A1 (en) 2018-05-10
US20080108088A1 (en) 2008-05-08
JP2003510037A (ja) 2003-03-18
WO2001018050A9 (en) 2002-02-07
US20100062456A1 (en) 2010-03-11
US20140120553A1 (en) 2014-05-01
US7868150B2 (en) 2011-01-11
US9817000B2 (en) 2017-11-14
US20050048586A1 (en) 2005-03-03
CN1387536A (zh) 2002-12-25
US8329885B2 (en) 2012-12-11
WO2001018050A3 (en) 2002-01-10
NO20021164L (no) 2002-05-10
US20130189712A1 (en) 2013-07-25
EP1214343A2 (en) 2002-06-19

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