MX9803633A - Procedimiento y dispositivo para la produccion de un preparado farmaceutico parenteral. - Google Patents

Procedimiento y dispositivo para la produccion de un preparado farmaceutico parenteral.

Info

Publication number
MX9803633A
MX9803633A MX9803633A MX9803633A MX9803633A MX 9803633 A MX9803633 A MX 9803633A MX 9803633 A MX9803633 A MX 9803633A MX 9803633 A MX9803633 A MX 9803633A MX 9803633 A MX9803633 A MX 9803633A
Authority
MX
Mexico
Prior art keywords
homogeniser
producing
nozzle
dispersion
pressure
Prior art date
Application number
MX9803633A
Other languages
English (en)
Spanish (es)
Inventor
Bernd Klinksiek
Said Mahiout
Ricarda Christine Nothelle
Hans Jurgen Hamman
Jurgen Sdebik
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX9803633A publication Critical patent/MX9803633A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/46—Homogenising or emulsifying nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/70—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming
    • B01F33/71—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming working at super-atmospheric pressure, e.g. in pressurised vessels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Plant Substances (AREA)
MX9803633A 1995-11-15 1998-05-07 Procedimiento y dispositivo para la produccion de un preparado farmaceutico parenteral. MX9803633A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19542499A DE19542499A1 (de) 1995-11-15 1995-11-15 Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung

Publications (1)

Publication Number Publication Date
MX9803633A true MX9803633A (es) 1998-09-30

Family

ID=7777475

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9803633A MX9803633A (es) 1995-11-15 1998-05-07 Procedimiento y dispositivo para la produccion de un preparado farmaceutico parenteral.

Country Status (11)

Country Link
US (1) US6331314B1 (https=)
EP (1) EP0861068B1 (https=)
JP (1) JP4049391B2 (https=)
AT (1) ATE222097T1 (https=)
CA (1) CA2237554C (https=)
DE (2) DE19542499A1 (https=)
DK (1) DK0861068T3 (https=)
ES (1) ES2180807T3 (https=)
MX (1) MX9803633A (https=)
PT (1) PT861068E (https=)
WO (1) WO1997017946A2 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1008380B1 (en) 1998-12-07 2004-03-10 F. Hoffmann-La Roche Ag Method and device for mixing or dispersing liquids
US20020119188A1 (en) * 2000-02-08 2002-08-29 Susan Niemiec Method of manufacturing liposomes
EP1222957A1 (en) * 2000-12-22 2002-07-17 Société des Produits Nestlé S.A. Process and device for producing a food grade oil-in-water emulsion
DE102004055507A1 (de) * 2004-11-17 2006-05-18 Basf Ag Verfahren zur Herstellung feinteiliger flüssig-flüssig Formulierungen und Vorrichtung zur Herstellung feinteiliger flüssig-flüssig Formulierungen
US20070231823A1 (en) * 2006-03-23 2007-10-04 Mckernan Kevin J Directed enrichment of genomic DNA for high-throughput sequencing
US7985058B2 (en) * 2007-01-12 2011-07-26 Mark Gray Method and apparatus for making uniformly sized particles
US7652175B2 (en) * 2007-06-27 2010-01-26 H R D Corporation High shear process for the production of acetaldehyde
US7479576B1 (en) * 2007-06-27 2009-01-20 H R D Corporation Method of hydrogenating aldehydes and ketones
US7491856B2 (en) 2007-06-27 2009-02-17 H R D Corporation Method of making alkylene glycols
US8304584B2 (en) 2007-06-27 2012-11-06 H R D Corporation Method of making alkylene glycols
WO2009001323A2 (en) * 2007-06-28 2008-12-31 The Procter & Gamble Company Apparatus and method for mixing of fluids by producing shear and/or cavitation, and components for such an apparatus
US8322910B2 (en) 2008-07-25 2012-12-04 The Procter & Gamble Company Apparatus and method for mixing by producing shear and/or cavitation, and components for apparatus
CN101617990B (zh) * 2009-07-31 2013-01-23 中国人民解放军第三军医大学 脂质体制备装置以及使用该装置制备脂质体的方法
JP5771366B2 (ja) 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
DE102009056883B4 (de) 2009-12-03 2012-08-16 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
RS52748B (sr) 2009-12-03 2013-08-30 Novartis Ag Cirkulacija komponenti tokom homogenizacije emulzija
EP2506832B1 (en) 2009-12-03 2014-02-26 Novartis AG Hydrophilic filtration during manufacture of vaccine adjuvants
CL2012001399A1 (es) 2009-12-03 2013-03-08 Novartis Ag Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.
DE102009056871A1 (de) 2009-12-03 2011-06-22 Novartis AG, 4056 Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
DE102009056884B4 (de) * 2009-12-03 2021-03-18 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CN120529961A (zh) * 2023-01-17 2025-08-22 帝斯曼知识产权资产管理有限公司 液体分散体制备工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
EP0082877A1 (en) * 1981-07-06 1983-07-06 Rush-Presbyterian-St.Luke's Medical Center Preparation of synthetic erythrocytes
CA1264668A (en) * 1984-06-20 1990-01-23 Pieter R. Cullis Extrusion techniques for producing liposomes
DE3515335C2 (de) 1985-04-27 1995-01-26 Bayer Ag Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung
DE4207481A1 (de) * 1992-03-10 1993-09-16 Bayer Ag Liposomale wirkstoff-formulierungen und verfahren zu ihrer herstellung
JPH08505312A (ja) * 1992-10-16 1996-06-11 ザックセ，アンドレアス 液状分散系を製造する方法及び装置
DE4328331A1 (de) * 1993-08-18 1995-02-23 Andreas Dr Sachse Kontinuierliches Hochdruckextrusionsverfahren zur Herstellung von Liposomen und Emulsionen

Also Published As

Publication number Publication date
JP2000500146A (ja) 2000-01-11
EP0861068A2 (de) 1998-09-02
CA2237554A1 (en) 1997-05-22
DE59609564D1 (de) 2002-09-19
WO1997017946A2 (de) 1997-05-22
DE19542499A1 (de) 1997-05-22
JP4049391B2 (ja) 2008-02-20
DK0861068T3 (da) 2002-12-02
EP0861068B1 (de) 2002-08-14
ES2180807T3 (es) 2003-02-16
ATE222097T1 (de) 2002-08-15
CA2237554C (en) 2007-01-09
US6331314B1 (en) 2001-12-18
WO1997017946A3 (de) 1997-09-12
PT861068E (pt) 2002-12-31

Similar Documents

Publication Publication Date Title
MX9803633A (es) Procedimiento y dispositivo para la produccion de un preparado farmaceutico parenteral.
MX9804837A (es) Un aparato y un metodo para emulsificar un liquido de componentes multiples presurizado.
TW347339B (en) Oral delivery of discrete units
CA2421385A1 (en) Fuel filling device and fuel leakage detection method
AU5924199A (en) Methods and apparatus for improved administration of fentanyl and sufentanil
BR0210332A (pt) Dispositivos nasais
AU1079701A (en) Oral transmucosal drug dosage using solid solution
CA2276170A1 (en) Sustained analgesia achieved with buprenorphine
WO2001036018A3 (en) Method and apparatus for relieving ailments using gases to increase the effectiveness of drugs
DE69933569D1 (de) Injektionshilfstorpedo für ein medizinisches injektionssystem
EP0855224A3 (en) Atomizer
GEP20022707B (en) Biodegrading Macromers for the Controlled Release of Biologically Active Substances
AU692042B2 (en) Transdermal system for the simultaneous delivery of a number of active principles
IL112145A (en) Active substance-containing patch for the controlled release of estradiol and a process for the production thereof
PL325825A1 (en) Microemulsion for use as a carrier for administering active compounds
WO2002056875A3 (en) Method of treatment of dopamine-related dysfunction through administration of a full d1 dopamine receptor agonist and with no induction of tolerance
WO2004105832A3 (en) Kinetic isolation pressurization
BR0004766A (pt) Processo para fornecimento tanto de pó quanto de gás em um lìquido, e, aparelho para proporcionar tanto pó quanto gás para um lìquido
EP1027837A3 (de) Anordnung zum Bildem einer Monolage aus einem kontinuerlich zugeführten dickschichtigen Materialstrom
EP0957261A3 (en) Fuel system and pump suitable for use therein
DE69827631D1 (en) Infusionsdüse
IL145668A0 (en) Needleless syringe
AU5658196A (en) Method for pharmaceutical delivery
WO2001013975A3 (en) Dna-based intramuscular injection system for humans
ZA942872B (en) Transdermal therapeutic systems for administering active substances