MX9710034A - Compuestos de bencimidazol. - Google Patents

Compuestos de bencimidazol.

Info

Publication number
MX9710034A
MX9710034A MX9710034A MX9710034A MX9710034A MX 9710034 A MX9710034 A MX 9710034A MX 9710034 A MX9710034 A MX 9710034A MX 9710034 A MX9710034 A MX 9710034A MX 9710034 A MX9710034 A MX 9710034A
Authority
MX
Mexico
Prior art keywords
alkyl
halo
phenyl
amino
independently
Prior art date
Application number
MX9710034A
Other languages
English (en)
Other versions
MXPA97010034A (es
Inventor
Takashi Mano
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX9710034A publication Critical patent/MX9710034A/es
Publication of MXPA97010034A publication Critical patent/MXPA97010034A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invencion proporciona un compuesto de la siguiente formula (I), y las sales farmacéuticamente aceptables del mismo, en lo que Ar es fenilo, cicloalquilo C3-8, cicloalquenilo C48, o heteroarilo; X2 y X3 son independientemente alquilo C1-4, halo, alquilo C1-4 halosubstituido, hidroxi, alcoxi C1-4, mercapto, (alquil C1-4)tio, (alquil C1-4)sulfinilo, (alquil C1-4)sulfonilo o grupos similares; X1 es H, halo, alquilo C1-4, hidroxi, ciano, nitro, (alquil C1-4)tio, (alquil C1-4)sulfinilo, (alquil C1-4)sulfonilo o grupos similares; Y es -CR1=CR2- o -C=_C-, en el que R1 y R2 son independientemente H, metilo, etilo o halo; 1 es 0, 1, 2, 3 o 4; y m y n son independientemente 0, 1, 2 o 3; con la condicion de que cuando Ar es fenilo, y 1, m y n son cero, entonces Y no es -CH=CH-; y cuando Ar es fenilo, 1 y m son cero, n es 1, e Y es -CH=CH-, entonces X3 no es alcoxi C1-4 unido a la posicion 2 de Ar ni amino, (alquil C1-4)amino o (dialquil C1-4)amino unido a la posicion 4 de Ar; y una composicion farmacéutica util para el tratamiento de un trastorno médico en el que están implicadas las prostaglandinas como patogenos.
MXPA/A/1997/010034A 1996-12-09 1997-12-09 Compuestos de bencimidazol MXPA97010034A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IBIB96/01395 1996-12-09
IB9601395 1996-12-09

Publications (2)

Publication Number Publication Date
MX9710034A true MX9710034A (es) 1998-06-30
MXPA97010034A MXPA97010034A (es) 1998-10-30

Family

ID=

Also Published As

Publication number Publication date
JPH10168066A (ja) 1998-06-23
CA2223551A1 (en) 1998-06-09
EP0846689A1 (en) 1998-06-10
DE69727199T2 (de) 2004-11-18
JP3439643B2 (ja) 2003-08-25
ES2212054T3 (es) 2004-07-16
EP0846689B1 (en) 2004-01-14
DE69727199D1 (de) 2004-02-19
DK0846689T3 (da) 2004-04-19
PT846689E (pt) 2004-06-30
BR9706241A (pt) 1999-05-18
CA2223551C (en) 2004-02-10
ATE257825T1 (de) 2004-01-15

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees