MX9709254A - Derivados de heterociclos policiclicos fusinados. - Google Patents

Derivados de heterociclos policiclicos fusinados.

Info

Publication number
MX9709254A
MX9709254A MX9709254A MX9709254A MX9709254A MX 9709254 A MX9709254 A MX 9709254A MX 9709254 A MX9709254 A MX 9709254A MX 9709254 A MX9709254 A MX 9709254A MX 9709254 A MX9709254 A MX 9709254A
Authority
MX
Mexico
Prior art keywords
ring
optionally substituted
aromatic ring
substituted monocyclic
polycyclic heterocycle
Prior art date
Application number
MX9709254A
Other languages
English (en)
Inventor
Hiroyuki Sugumi
Niijimajun
Yoshihiko Kotake
Toshimi Okada
-Ichi Jun Kamat
Kentaro Yoshimatsu
Takeshi Nagasu
Katsuji Nakamura
Toshimitsu Uenaka
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority claimed from PCT/JP1996/001487 external-priority patent/WO1996038446A1/ja
Publication of MX9709254A publication Critical patent/MX9709254A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nuevos derivados de heterociclo policíclico fusionado que tienen excelentes efectos antitumorales y un procedimiento para la produccion de los mismos. Un compuesto representado por la siguiente formula general (I) o sales farmacologicamente aceptables del mismo: donde el anillo A representa un anillo aromático monocíclico opcionalmente sustituido o un anillo fusionado dicíclico en el cual menos uno de los anillos en un anillo aromático; el anillo B representa pirrol, 4H-1,4-oxazina, 4H-1,4-tiazina o 4(1H)-piridona; el anillo C representa un anillo aromático fusionado monocíclico o dicíclico, opcionalmente sustituido; e Y representa un grupo representado por la formula -e-f- (donde e representa alquileno inferior; y f representa amidino, guanidino o amino opcionalmente sustituido por alquilo inferior opcionalmente hidroxilado u opcionalmente alquilaminado; con la condicion de que los casos en que los anillos A y B sean ambos anillos aromáticos monocíclicos opcionalmente sustituidos están excluidos el cual tiene una excelente actividad antitumoral.
MX9709254A 1995-05-31 1996-05-31 Derivados de heterociclos policiclicos fusinados. MX9709254A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13399295 1995-05-31
JP30919595 1995-11-28
PCT/JP1996/001487 WO1996038446A1 (fr) 1995-05-31 1996-05-31 Derives heterocycliques polycycliques fusionnes

Publications (1)

Publication Number Publication Date
MX9709254A true MX9709254A (es) 1998-03-31

Family

ID=26468199

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9709254A MX9709254A (es) 1995-05-31 1996-05-31 Derivados de heterociclos policiclicos fusinados.

Country Status (12)

Country Link
US (1) US5952335A (es)
EP (1) EP0831094B1 (es)
KR (1) KR100399704B1 (es)
CN (1) CN1067686C (es)
AT (1) ATE284401T1 (es)
AU (1) AU703111B2 (es)
DE (1) DE69634004T2 (es)
ES (1) ES2229272T3 (es)
HU (1) HUP9802672A3 (es)
MX (1) MX9709254A (es)
NO (1) NO310149B1 (es)
NZ (1) NZ308657A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164564B4 (de) * 2001-12-14 2007-05-16 Zentaris Gmbh Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR)
WO2004063156A1 (en) * 2003-01-08 2004-07-29 Biovitrum Ab Novel indole derivates as fabp-4 inhibitors
JP2008501719A (ja) * 2004-06-04 2008-01-24 ケムジェネックス・ファーマシューティカルズ・インコーポレイテッド ナフタルイミドおよびｐａｒｐ−１インヒビターを使用する細胞増殖性疾患の処置方法
WO2010148350A1 (en) * 2009-06-18 2010-12-23 Cornell University Photoproducts of tryptophan, their synthesis and uses thereof
CN104098506A (zh) * 2014-07-15 2014-10-15 华东理工大学 一类苯并[c]咔唑酰胺化合物的制备方法及用途
CN107141295A (zh) * 2017-05-27 2017-09-08 重庆文理学院 一种尿嘧啶类衍生物的简易合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962438A (en) * 1975-01-07 1976-06-08 Smithkline Corporation Anti-arthritic 1H-pyrimido-(5,4,3-kl)phenothiazine-1,3(2H)-diones and 1-thiones
AU643539B2 (en) * 1990-06-26 1993-11-18 Research Corporation Technologies, Inc. 1,2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents

Also Published As

Publication number Publication date
ES2229272T3 (es) 2005-04-16
HUP9802672A3 (en) 2000-04-28
CN1067686C (zh) 2001-06-27
AU703111B2 (en) 1999-03-18
DE69634004D1 (de) 2005-01-13
EP0831094B1 (en) 2004-12-08
NO975493L (no) 1998-01-29
US5952335A (en) 1999-09-14
ATE284401T1 (de) 2004-12-15
EP0831094A4 (en) 2001-11-21
NO310149B1 (no) 2001-05-28
AU5845496A (en) 1996-12-18
KR19990022186A (ko) 1999-03-25
HUP9802672A2 (hu) 1999-04-28
CN1185781A (zh) 1998-06-24
EP0831094A1 (en) 1998-03-25
KR100399704B1 (ko) 2003-12-18
NO975493D0 (no) 1997-11-28
DE69634004T2 (de) 2005-11-10
NZ308657A (en) 1999-10-28

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Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: EISAI R&D MANAGEMENT CO., LTD.*

MM Annulment or lapse due to non-payment of fees