MX9701916A - Procedimiento para la investigacion de la interaccion de biomoleculas mediante resonancia de plasmones en la superficie. - Google Patents
Procedimiento para la investigacion de la interaccion de biomoleculas mediante resonancia de plasmones en la superficie.Info
- Publication number
- MX9701916A MX9701916A MX9701916A MX9701916A MX9701916A MX 9701916 A MX9701916 A MX 9701916A MX 9701916 A MX9701916 A MX 9701916A MX 9701916 A MX9701916 A MX 9701916A MX 9701916 A MX9701916 A MX 9701916A
- Authority
- MX
- Mexico
- Prior art keywords
- growth hormone
- patient
- igf
- serum level
- below normal
- Prior art date
Links
- 208000022967 Short stature due to partial GHR deficiency Diseases 0.000 title abstract 2
- 208000011580 syndromic disease Diseases 0.000 title abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 4
- 108010051696 Growth Hormone Proteins 0.000 abstract 4
- 239000000122 growth hormone Substances 0.000 abstract 4
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 3
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 3
- 210000002966 serum Anatomy 0.000 abstract 3
- 102100020948 Growth hormone receptor Human genes 0.000 abstract 1
- 208000006302 Laron syndrome Diseases 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 1
- 108010033419 somatotropin-binding protein Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La invencion es concerniente con un proceso, una unidad biodetectora la cual puede ser regenerada y equipos apropiados para investigar la interaccion entre las biomoleculas por medio de resonancia de plasmos superficial (SPR). Uno de los reactivos, un (poli) péptido, se acopla a la superficie de la unidad biodetectora por medio de un quelato de metal. Los derivados de ácido nitrilotriacético a los cuales las proteínas con una afinidad al péptido que contiene grupos de histadina se pueden enlazar se utilizan de preferencia como formadores de quelatos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/224,982 US5646113A (en) | 1994-04-07 | 1994-04-07 | Treatment of partial growth hormone insensitivity syndrome |
PCT/US1995/003731 WO1995027495A2 (en) | 1994-04-07 | 1995-03-24 | Treatment of partial growth hormone insensitivity syndrome |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9701916A true MX9701916A (es) | 1997-06-28 |
Family
ID=22843052
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9604635A MX9604635A (es) | 1994-04-07 | 1995-03-24 | Tratamiento del sindrome de insensibilidad parcial a la hormona del crecimiento. |
MX9701916A MX9701916A (es) | 1994-04-07 | 1995-03-24 | Procedimiento para la investigacion de la interaccion de biomoleculas mediante resonancia de plasmones en la superficie. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9604635A MX9604635A (es) | 1994-04-07 | 1995-03-24 | Tratamiento del sindrome de insensibilidad parcial a la hormona del crecimiento. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5646113A (es) |
EP (1) | EP0754048B1 (es) |
JP (2) | JP3366644B2 (es) |
AT (1) | ATE203165T1 (es) |
CA (1) | CA2187274C (es) |
DE (1) | DE69521796T2 (es) |
DK (1) | DK0754048T3 (es) |
ES (1) | ES2160704T3 (es) |
GR (1) | GR3036901T3 (es) |
MX (2) | MX9604635A (es) |
PT (1) | PT754048E (es) |
WO (1) | WO1995027495A2 (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US6207640B1 (en) * | 1994-04-07 | 2001-03-27 | Genentech, Inc. | Treatment of partial growth hormone insensitivity syndrome |
US5545553A (en) * | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
EP2267026A1 (en) | 2000-04-12 | 2010-12-29 | Human Genome Sciences, Inc. | Albumin fusion proteins |
GB0106565D0 (en) * | 2001-03-16 | 2001-05-09 | Leuven K U Res & Dev | Growth hormone treatment |
CA2446739A1 (en) * | 2001-05-25 | 2002-12-05 | Human Genome Sciences, Inc. | Chemokine beta-1 fusion proteins |
US7179617B2 (en) * | 2001-10-10 | 2007-02-20 | Neose Technologies, Inc. | Factor IX: remolding and glycoconjugation of Factor IX |
WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US7696163B2 (en) * | 2001-10-10 | 2010-04-13 | Novo Nordisk A/S | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7795210B2 (en) | 2001-10-10 | 2010-09-14 | Novo Nordisk A/S | Protein remodeling methods and proteins/peptides produced by the methods |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US8008252B2 (en) * | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
PT1463751E (pt) | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Proteínas de fusão de albumina |
WO2005003296A2 (en) | 2003-01-22 | 2005-01-13 | Human Genome Sciences, Inc. | Albumin fusion proteins |
MXPA04012496A (es) | 2002-06-21 | 2005-09-12 | Novo Nordisk Healthcare Ag | Glicoformos del factor vii pegilados. |
BRPI0408358A (pt) | 2003-03-14 | 2006-03-21 | Neose Technologies Inc | polìmeros hidrossolúveis ramificados e seus conjugados |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
AU2004240553A1 (en) | 2003-05-09 | 2004-12-02 | Neose Technologies, Inc. | Compositions and methods for the preparation of human growth hormone glycosylation mutants |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
CA2538342C (en) * | 2003-09-12 | 2013-01-08 | Tercica, Inc. | Methods for treatment of insulin-like growth factor-1 (igf-1) deficiency |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US7842661B2 (en) | 2003-11-24 | 2010-11-30 | Novo Nordisk A/S | Glycopegylated erythropoietin formulations |
US20060040856A1 (en) * | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
US7956032B2 (en) * | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
US20080318850A1 (en) * | 2003-12-03 | 2008-12-25 | Neose Technologies, Inc. | Glycopegylated Factor Ix |
CA2552892C (en) | 2004-01-08 | 2014-08-05 | Neose Technologies, Inc. | O-linked glycosylation of peptides |
KR20120134158A (ko) * | 2004-03-17 | 2012-12-11 | 안티캔서, 인코포레이티드 | 폴리에틸렌 글리콜(peg) 단백질 결합을 증가시키기 위한 방법 |
WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
WO2006020372A2 (en) * | 2004-07-23 | 2006-02-23 | Neose Technologies, Inc. | Enzymatic modification of glycopeptides |
US8268967B2 (en) | 2004-09-10 | 2012-09-18 | Novo Nordisk A/S | Glycopegylated interferon α |
EP1814573B1 (en) | 2004-10-29 | 2016-03-09 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
ES2449195T3 (es) | 2005-01-10 | 2014-03-18 | Ratiopharm Gmbh | Factor estimulante de colonias de granulocitos glicopegilado |
WO2006105426A2 (en) * | 2005-03-30 | 2006-10-05 | Neose Technologies, Inc. | Manufacturing process for the production of peptides grown in insect cell lines |
EP1871795A4 (en) | 2005-04-08 | 2010-03-31 | Biogenerix Ag | COMPOSITIONS AND METHOD FOR PRODUCING GLYCOSYLATION MUTANTS OF A PROTEASE-RESISTANT HUMAN GROWTH HORMONE |
US20080255026A1 (en) * | 2005-05-25 | 2008-10-16 | Glycopegylated Factor 1X | Glycopegylated Factor Ix |
WO2006130769A2 (en) * | 2005-06-02 | 2006-12-07 | Tercica, Inc. | Methods for treatment of growth disorders |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
CN101516388B (zh) * | 2006-07-21 | 2012-10-31 | 诺和诺德公司 | 通过o-联糖基化序列的肽的糖基化 |
WO2008057683A2 (en) | 2006-10-03 | 2008-05-15 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
KR20100016160A (ko) | 2007-04-03 | 2010-02-12 | 바이오제너릭스 에이지 | 글리코페길화 g―csf를 이용하는 치료 방법 |
WO2008154639A2 (en) | 2007-06-12 | 2008-12-18 | Neose Technologies, Inc. | Improved process for the production of nucleotide sugars |
US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
ES2476690T3 (es) | 2008-02-27 | 2014-07-15 | Novo Nordisk A/S | Moléculas conjugadas del Factor VIII |
US10383919B1 (en) * | 2013-05-31 | 2019-08-20 | The University of the Sciences | Fragments of growth hormone binding protein |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
-
1994
- 1994-04-07 US US08/224,982 patent/US5646113A/en not_active Expired - Lifetime
-
1995
- 1995-03-24 DE DE69521796T patent/DE69521796T2/de not_active Expired - Lifetime
- 1995-03-24 EP EP95914872A patent/EP0754048B1/en not_active Expired - Lifetime
- 1995-03-24 PT PT95914872T patent/PT754048E/pt unknown
- 1995-03-24 AT AT95914872T patent/ATE203165T1/de active
- 1995-03-24 MX MX9604635A patent/MX9604635A/es unknown
- 1995-03-24 DK DK95914872T patent/DK0754048T3/da active
- 1995-03-24 ES ES95914872T patent/ES2160704T3/es not_active Expired - Lifetime
- 1995-03-24 MX MX9701916A patent/MX9701916A/es unknown
- 1995-03-24 WO PCT/US1995/003731 patent/WO1995027495A2/en active IP Right Grant
- 1995-03-24 CA CA002187274A patent/CA2187274C/en not_active Expired - Lifetime
- 1995-03-24 JP JP52635695A patent/JP3366644B2/ja not_active Expired - Lifetime
-
2000
- 2000-01-07 JP JP2000001444A patent/JP2000226334A/ja active Pending
-
2001
- 2001-10-16 GR GR20010401771T patent/GR3036901T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH09509430A (ja) | 1997-09-22 |
GR3036901T3 (en) | 2002-01-31 |
EP0754048A1 (en) | 1997-01-22 |
ATE203165T1 (de) | 2001-08-15 |
DK0754048T3 (da) | 2001-11-05 |
JP3366644B2 (ja) | 2003-01-14 |
EP0754048B1 (en) | 2001-07-18 |
ES2160704T3 (es) | 2001-11-16 |
US5646113A (en) | 1997-07-08 |
WO1995027495A3 (en) | 1995-12-28 |
PT754048E (pt) | 2002-01-30 |
MX9604635A (es) | 1997-11-29 |
WO1995027495A2 (en) | 1995-10-19 |
DE69521796D1 (de) | 2001-08-23 |
CA2187274A1 (en) | 1995-10-19 |
CA2187274C (en) | 2001-01-02 |
JP2000226334A (ja) | 2000-08-15 |
DE69521796T2 (de) | 2002-05-23 |
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