MX9604309A - Aumento de la eficacia de drogas por deuteracion. - Google Patents
Aumento de la eficacia de drogas por deuteracion.Info
- Publication number
- MX9604309A MX9604309A MX9604309A MX9604309A MX9604309A MX 9604309 A MX9604309 A MX 9604309A MX 9604309 A MX9604309 A MX 9604309A MX 9604309 A MX9604309 A MX 9604309A MX 9604309 A MX9604309 A MX 9604309A
- Authority
- MX
- Mexico
- Prior art keywords
- nifedipine
- drugs
- isotope
- molecular
- deuterated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
Abstract
La presente invencion se refiere a un procedimiento para aumentar la eficacia de productos farmacéuticos o drogas conocidas y a las drogas mejoradas así producidas , por el cambio de la forma isotopica de la estructura molecular de la droga conocida. Más particularmente, la presente invencion se refiere a la modificacion de la estructura molecular de drogas conocidas, que contienen uno o más átomos de hidrogeno, por la deuteracion de uno o más de estos átomos de hidrogeno en átomos de deuterio. La droga resultante se altera significantemente y tiene una actividad mejorada sobre la droga conocida. Más
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21789794A | 1994-03-25 | 1994-03-25 | |
| US217897 | 1994-03-25 | ||
| PCT/CA1995/000154 WO1995026325A2 (en) | 1994-03-25 | 1995-03-27 | Enhancement of the efficacy of drugs by deuteration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9604309A true MX9604309A (es) | 1998-05-31 |
| MXPA96004309A MXPA96004309A (es) | 1998-10-23 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| BR9507200A (pt) | 1997-09-16 |
| ES2293638T3 (es) | 2008-03-16 |
| WO1995026325A2 (en) | 1995-10-05 |
| KR100477070B1 (ko) | 2006-04-21 |
| DE69535592T2 (de) | 2008-06-12 |
| WO1995026325A3 (en) | 1995-12-14 |
| DE69535592D1 (de) | 2007-10-25 |
| CN1087725C (zh) | 2002-07-17 |
| KR20040068613A (ko) | 2004-07-31 |
| JP3696884B2 (ja) | 2005-09-21 |
| EP0751926A1 (en) | 1997-01-08 |
| CA2186371A1 (en) | 1995-10-05 |
| ATE372966T1 (de) | 2007-09-15 |
| JPH09510717A (ja) | 1997-10-28 |
| EP0751926B1 (en) | 2007-09-12 |
| AU707748B2 (en) | 1999-07-22 |
| CN1148843A (zh) | 1997-04-30 |
| US5846514A (en) | 1998-12-08 |
| AU1944195A (en) | 1995-10-17 |
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