MX9308014A - Peptidos antagonistas de la hormona liberadora de la hormona luteinizante. - Google Patents

Peptidos antagonistas de la hormona liberadora de la hormona luteinizante.

Info

Publication number
MX9308014A
MX9308014A MX9308014A MX9308014A MX9308014A MX 9308014 A MX9308014 A MX 9308014A MX 9308014 A MX9308014 A MX 9308014A MX 9308014 A MX9308014 A MX 9308014A MX 9308014 A MX9308014 A MX 9308014A
Authority
MX
Mexico
Prior art keywords
hormone
antagonist peptides
luteinizing
alkylated
releasing hormone
Prior art date
Application number
MX9308014A
Other languages
English (en)
Inventor
Daryl R Sauer
Fortuna Haviv
Jonathan Greet
Rolf E Swenson
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX9308014A publication Critical patent/MX9308014A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se proporciona una clase de poderosos antagonistas decapéptido de LHRH que poseen residuos aminoacilo N alquilados, en los que la porción de cadena lateral de residuo es un grupo 4-(amino sustituido)fenilalanilo, 4-(amino sustituido)ciclohexilanilo, o Û-(amino sustituido)alquilo y opcionalmente los residuos aminoacidos en la posición 5 están N alquilados en el átomo de nitrógeno del esqueleto peptídico.
MX9308014A 1992-12-18 1993-12-15 Peptidos antagonistas de la hormona liberadora de la hormona luteinizante. MX9308014A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99320292A 1992-12-18 1992-12-18

Publications (1)

Publication Number Publication Date
MX9308014A true MX9308014A (es) 1994-08-31

Family

ID=25539225

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9308014A MX9308014A (es) 1992-12-18 1993-12-15 Peptidos antagonistas de la hormona liberadora de la hormona luteinizante.

Country Status (11)

Country Link
US (1) US5491217A (es)
EP (1) EP0683792B1 (es)
JP (1) JP3568952B2 (es)
AT (1) ATE206136T1 (es)
CA (1) CA2136079A1 (es)
DE (1) DE69330838T2 (es)
DK (1) DK0683792T3 (es)
ES (1) ES2164096T3 (es)
MX (1) MX9308014A (es)
PT (1) PT683792E (es)
WO (1) WO1994014841A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801577A (en) * 1987-02-05 1989-01-31 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US5516759A (en) * 1994-12-08 1996-05-14 Tap Holdings Inc. LHRH antagonists having lactam groups at the N-terminus
US5681928A (en) * 1994-12-16 1997-10-28 The Salk Institute For Biological Studies Betides and methods for screening peptides using same
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
DE19544212A1 (de) * 1995-11-28 1997-06-05 Asta Medica Ag Neue LH-RH-Antagonisten mit verbesserter Wirkung
US5925730A (en) 1997-04-11 1999-07-20 Ferring Bv GnRH antagonists
RU2248982C9 (ru) 2000-03-14 2005-06-10 Центарис Гмбх Антагонисты lhrh, их получение, фармацевтическая композиция и ее получение, способ лечения опухолей и бесплодия у млекопитающих
US7098305B2 (en) 2001-09-06 2006-08-29 Ardana Bioscience Limited Sustained release of microcrystalline peptide suspensions
SG173223A1 (en) 2003-04-22 2011-08-29 Ipsen Pharma Sas Peptide vectors
CN101987865B (zh) * 2009-07-29 2014-07-30 中国人民解放军军事医学科学院毒物药物研究所 含有乙内酰脲结构的促黄体生成素释放激素拮抗剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4317815A (en) * 1979-06-13 1982-03-02 Coy David Howard LH-RH Antagonists
DE3165535D1 (en) * 1980-06-02 1984-09-20 Andrew Victor Schally Lh-rh antagonists
US4481190A (en) * 1982-12-21 1984-11-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4667014A (en) * 1983-03-07 1987-05-19 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4530920A (en) * 1983-11-07 1985-07-23 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US5073624A (en) * 1985-04-09 1991-12-17 Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US5171835A (en) * 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
US5169932A (en) * 1989-10-30 1992-12-08 The Salk Institute For Biological Studies Gnrh analogs
CN1036343C (zh) * 1990-11-10 1997-11-05 天津市计划生育研究所 新促黄体生成素释放激素拮抗类似物的制备方法
IL108509A0 (en) * 1993-02-22 1994-05-30 Salk Inst For Biological Studi GnRH antagonist peptides

Also Published As

Publication number Publication date
ES2164096T3 (es) 2002-02-16
JP3568952B2 (ja) 2004-09-22
ATE206136T1 (de) 2001-10-15
DE69330838T2 (de) 2002-04-25
WO1994014841A1 (en) 1994-07-07
US5491217A (en) 1996-02-13
DK0683792T3 (da) 2002-01-14
EP0683792B1 (en) 2001-09-26
EP0683792A4 (en) 1998-11-18
DE69330838D1 (de) 2001-10-31
EP0683792A1 (en) 1995-11-29
JPH08505611A (ja) 1996-06-18
CA2136079A1 (en) 1994-07-07
PT683792E (pt) 2002-03-28

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees