RU93058365A - Пептидные соединения и содержащее их лекарственное средство - Google Patents
Пептидные соединения и содержащее их лекарственное средствоInfo
- Publication number
- RU93058365A RU93058365A RU93058365/04A RU93058365A RU93058365A RU 93058365 A RU93058365 A RU 93058365A RU 93058365/04 A RU93058365/04 A RU 93058365/04A RU 93058365 A RU93058365 A RU 93058365A RU 93058365 A RU93058365 A RU 93058365A
- Authority
- RU
- Russia
- Prior art keywords
- denotes
- neu
- peptide compounds
- containing medicine
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960003589 Arginine hydrochloride Drugs 0.000 claims 1
- 102100000899 GNRH1 Human genes 0.000 claims 1
- 108010084340 Gonadotropin-Releasing Hormone Proteins 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- XLXSAKCOAKORKW-KPKRHBJMSA-N N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl] Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-KPKRHBJMSA-N 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 230000003042 antagnostic Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 201000009273 endometriosis Diseases 0.000 claims 1
- 230000035558 fertility Effects 0.000 claims 1
- 201000001514 prostate carcinoma Diseases 0.000 claims 1
- 0 CC(C(*C(*)C*O*)N)=O Chemical compound CC(C(*C(*)C*O*)N)=O 0.000 description 1
Claims (1)
- Изобретение касается LHRH-антагонистов общей формулы:где X обозначает ацильную группу, X1 обозначает D-Nal, X2 обозначает D-(4-Cl)-Phe, X3 обозначает D - (3) - Pal, X6 обозначает D-Cit или D-Neu, X8 обозначает L-Arg или L-neu, причем по меньшей мере один из остатков X6 и X8 представляет собой Neu, X1 0 обозначает D-Ala-NH2, причем Neu представляет собой группу формулы:
Изобретение охватывает лекарства, содержащие соединение формулы и обычные вспомогательные вещества и носители. Лекарства применяются для лечения карциномы простаты, эндометриозы и для контроля плодовитости.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4117507.7 | 1991-05-24 | ||
| DE4117507A DE4117507A1 (de) | 1991-05-24 | 1991-05-24 | Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93058365A true RU93058365A (ru) | 1996-04-27 |
| RU2124023C1 RU2124023C1 (ru) | 1998-12-27 |
Family
ID=6432667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93058365A RU2124023C1 (ru) | 1991-05-24 | 1992-05-22 | Производные декапептидов и содержащая их фармацевтическая композиция |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5527777A (ru) |
| EP (1) | EP0668874B1 (ru) |
| JP (1) | JP3370668B2 (ru) |
| AT (1) | ATE170190T1 (ru) |
| AU (1) | AU667038B2 (ru) |
| CA (1) | CA2109830C (ru) |
| DE (3) | DE4117507A1 (ru) |
| DK (1) | DK0668874T3 (ru) |
| ES (1) | ES2123554T3 (ru) |
| FI (2) | FI105817B (ru) |
| HU (1) | HU219912B (ru) |
| NO (1) | NO311725B1 (ru) |
| RU (1) | RU2124023C1 (ru) |
| WO (1) | WO1992020711A2 (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4801577A (en) * | 1987-02-05 | 1989-01-31 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
| US5843901A (en) * | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| US5932547A (en) | 1996-07-03 | 1999-08-03 | Alza Corporation | Non-aqueous polar aprotic peptide formulations |
| US5916582A (en) * | 1996-07-03 | 1999-06-29 | Alza Corporation | Aqueous formulations of peptides |
| US5981489A (en) * | 1996-07-18 | 1999-11-09 | Alza Corporation | Non-aqueous protic peptide formulations |
| US6455499B1 (en) | 1999-02-23 | 2002-09-24 | Indiana University Foundation | Methods for treating disorders associated with LHRH activity |
| DE19911771B4 (de) * | 1999-03-17 | 2006-03-30 | Zentaris Gmbh | LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung |
| GB201009603D0 (en) * | 2010-06-08 | 2010-07-21 | Cambridge Entpr Ltd | Anti-inflammatory agent |
| AR122446A1 (es) * | 2020-04-29 | 2022-09-14 | Medimmune Llc | Composiciones y métodos para suministrar agentes farmacéuticamente activos |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4667014A (en) * | 1983-03-07 | 1987-05-19 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| US4801577A (en) * | 1987-02-05 | 1989-01-31 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
| US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
| US4935491A (en) * | 1987-08-24 | 1990-06-19 | Board Of Regents, The University Of Texas System | Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine |
| IE902446A1 (en) * | 1989-07-26 | 1991-02-13 | Abbott Lab | Peptidyl aminodiol renin inhibitors |
-
1991
- 1991-05-24 DE DE4117507A patent/DE4117507A1/de not_active Withdrawn
-
1992
- 1992-05-22 CA CA002109830A patent/CA2109830C/en not_active Expired - Fee Related
- 1992-05-22 JP JP50975692A patent/JP3370668B2/ja not_active Expired - Fee Related
- 1992-05-22 EP EP92910746A patent/EP0668874B1/de not_active Expired - Lifetime
- 1992-05-22 HU HU9303324A patent/HU219912B/hu not_active IP Right Cessation
- 1992-05-22 AT AT92910746T patent/ATE170190T1/de not_active IP Right Cessation
- 1992-05-22 AU AU18879/92A patent/AU667038B2/en not_active Ceased
- 1992-05-22 US US08/142,429 patent/US5527777A/en not_active Expired - Fee Related
- 1992-05-22 WO PCT/DE1992/000427 patent/WO1992020711A2/de active IP Right Grant
- 1992-05-22 ES ES92910746T patent/ES2123554T3/es not_active Expired - Lifetime
- 1992-05-22 DE DEDE9200427T patent/DE4291426D2/de not_active Expired - Lifetime
- 1992-05-22 DK DK92910746T patent/DK0668874T3/da active
- 1992-05-22 DE DE59209476T patent/DE59209476D1/de not_active Expired - Lifetime
- 1992-05-22 RU RU93058365A patent/RU2124023C1/ru not_active IP Right Cessation
-
1993
- 1993-11-23 NO NO19934237A patent/NO311725B1/no unknown
- 1993-11-23 FI FI935191A patent/FI105817B/fi not_active IP Right Cessation
-
1999
- 1999-06-24 FI FI991441A patent/FI114026B/fi not_active IP Right Cessation
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