MX9307610A - Decapeptido modificado en la posicion 6 y composicion farmaceutica que locontiene. - Google Patents

Decapeptido modificado en la posicion 6 y composicion farmaceutica que locontiene.

Info

Publication number
MX9307610A
MX9307610A MX9307610A MX9307610A MX9307610A MX 9307610 A MX9307610 A MX 9307610A MX 9307610 A MX9307610 A MX 9307610A MX 9307610 A MX9307610 A MX 9307610A MX 9307610 A MX9307610 A MX 9307610A
Authority
MX
Mexico
Prior art keywords
pharmaceutical composition
group
decapeptide
local pharmaceutical
modified
Prior art date
Application number
MX9307610A
Other languages
English (en)
Inventor
Jonathan Greer
Timothy D Fitzpatrick
Charles J Nichols
Fortuna Haviv
Rolf E Swenson
Nicholas A Mort
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX9307610A publication Critical patent/MX9307610A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona una clase de compuestos decapéptidos queson potentes antagonistas de la actividad de la LHRH, los cuales tienenla estructura A1-D2-E3-G4-J5-L6-M7-Q8-R9-T10. Los compuestos de lapresente invención se caracterizan por tener una cadena lateralfuncionalizada del grupo Û-amino sobre el residuo D-aminoacilo en laposición 6. El grupo Û-amino de esta cadena lateral además está derivadode la unión de un grupo diluente que también tiene un grupo amino terminalcoronado por un grupo acilo.
MX9307610A 1992-12-04 1993-12-02 Decapeptido modificado en la posicion 6 y composicion farmaceutica que locontiene. MX9307610A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98792192A 1992-12-04 1992-12-04

Publications (1)

Publication Number Publication Date
MX9307610A true MX9307610A (es) 1995-01-31

Family

ID=25533694

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9307610A MX9307610A (es) 1992-12-04 1993-12-02 Decapeptido modificado en la posicion 6 y composicion farmaceutica que locontiene.

Country Status (6)

Country Link
US (1) US5698522A (es)
EP (1) EP0673254A4 (es)
JP (1) JPH08504209A (es)
CA (1) CA2136078A1 (es)
MX (1) MX9307610A (es)
WO (1) WO1994013313A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
DE19544212A1 (de) * 1995-11-28 1997-06-05 Asta Medica Ag Neue LH-RH-Antagonisten mit verbesserter Wirkung
US5942493A (en) * 1995-11-28 1999-08-24 Asta Medica Aktiengesellschaft LH-RH antagonists having improved action
US5710247A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process and intermediates for the synthesis of LHRH antagonists
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
WO1999026964A1 (en) * 1997-11-20 1999-06-03 Ortho-Mcneil Pharmaceutical, Inc. LIQUID PHASE PROCESS FOR THE PREPARATION OF GnRH PEPTIDES
US6395559B1 (en) 1999-05-04 2002-05-28 Orchid Biosciences, Inc. Multiple fluid sample processor with single well addressability
DE50114335D1 (de) 2000-03-14 2008-10-30 Aeterna Zentaris Gmbh Lh-rh-antagonisten, deren herstellung und verwendung als arzneimittel
US7098305B2 (en) 2001-09-06 2006-08-29 Ardana Bioscience Limited Sustained release of microcrystalline peptide suspensions
ES2626013T3 (es) 2011-09-06 2017-07-21 Novo Nordisk A/S Derivados de GLP-1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
US5140009A (en) * 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
US5413990A (en) * 1993-08-06 1995-05-09 Tap Pharmaceuticals Inc. N-terminus modified analogs of LHRH
CA2167834A1 (en) * 1993-08-06 1995-02-16 Fortuna Haviv N-terminus modified analogs of lhrh

Also Published As

Publication number Publication date
US5698522A (en) 1997-12-16
WO1994013313A1 (en) 1994-06-23
CA2136078A1 (en) 1994-06-23
JPH08504209A (ja) 1996-05-07
EP0673254A4 (en) 1998-11-18
EP0673254A1 (en) 1995-09-27

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees