MX9207557A - Derivados de acidos benzofuranil- y tiofenilmetiltio-alcanocarboxilicos, procedimiento para su preparacion y medicamentos que los contienen. - Google Patents

Derivados de acidos benzofuranil- y tiofenilmetiltio-alcanocarboxilicos, procedimiento para su preparacion y medicamentos que los contienen.

Info

Publication number
MX9207557A
MX9207557A MX9207557A MX9207557A MX9207557A MX 9207557 A MX9207557 A MX 9207557A MX 9207557 A MX9207557 A MX 9207557A MX 9207557 A MX9207557 A MX 9207557A MX 9207557 A MX9207557 A MX 9207557A
Authority
MX
Mexico
Prior art keywords
derivatives
medicines
acids
tiofenilmetiltio
alcanocarboxilicos
Prior art date
Application number
MX9207557A
Other languages
English (en)
Inventor
John-E Butler-Ransohoff
Graham Sturton
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX9207557A publication Critical patent/MX9207557A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Se preparan derivados de ácidos benzofuranil- y tiofenilmetiltio-alcanocarboxílicos bromado compuestos de metilo apropiados y haciendo reaccionar los bromuros de metilo así obtenidos con derivados de ácidos mercapto-alcanocarboxílicos. Las nuevas sustancias son adecuadas como inhibidores de oxidasa NADPH para su uso en medicamentos, en particular para el tratamiento de procesos inflamatorios agudos y crónicos.
MX9207557A 1992-01-13 1992-12-24 Derivados de acidos benzofuranil- y tiofenilmetiltio-alcanocarboxilicos, procedimiento para su preparacion y medicamentos que los contienen. MX9207557A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929200623A GB9200623D0 (en) 1992-01-13 1992-01-13 Benzofuranyl and thiophenyl-methylthio-alkanecarboxylic acid derivatives

Publications (1)

Publication Number Publication Date
MX9207557A true MX9207557A (es) 1993-07-01

Family

ID=10708497

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9207557A MX9207557A (es) 1992-01-13 1992-12-24 Derivados de acidos benzofuranil- y tiofenilmetiltio-alcanocarboxilicos, procedimiento para su preparacion y medicamentos que los contienen.

Country Status (13)

Country Link
EP (1) EP0551662A1 (es)
JP (1) JPH05271214A (es)
KR (1) KR930016413A (es)
CN (1) CN1074904A (es)
AU (1) AU3108293A (es)
CA (1) CA2086987A1 (es)
GB (1) GB9200623D0 (es)
HU (1) HUT64952A (es)
IL (1) IL104356A0 (es)
MX (1) MX9207557A (es)
PL (1) PL297337A1 (es)
TW (1) TW212796B (es)
ZA (1) ZA93190B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69507197T2 (de) * 1994-05-31 1999-05-27 Bayer Ag Aminobenzofuryl- und -thienylderivate
HRP950288A2 (en) * 1994-05-31 1997-08-31 Bayer Ag Oxalylamino-benzofuran- and benzothienyl-derivatives
GB9410877D0 (en) * 1994-05-31 1994-07-20 Bayer Ag Heterocyclycarbonyl substituted benzoduranyl-and-thiophenyl-alkanecarboxyclic acid derivatives
GB9504460D0 (en) * 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives
US5763496A (en) * 1995-11-27 1998-06-09 The Research Foundation Of State University Of New York Prevention of atherosclerosis using NADPH oxidase inhibitors
GB9614718D0 (en) 1996-07-12 1996-09-04 Bayer Ag 3-ureido-pyridofurans and -pyridothiophenes
US5908859A (en) * 1997-08-11 1999-06-01 Eli Lilly And Company Benzothiophenes for inhibiting hyperlipidemia
WO1999012539A1 (en) * 1997-09-10 1999-03-18 The Johns Hopkins University School Of Medicine The use of an nadph-oxidase inhibitor in the treatment of reperfusion injury
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
NZ534255A (en) 2002-02-22 2007-06-29 Bayer Pharmaceuticals Corp Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
US7144885B2 (en) 2002-02-22 2006-12-05 Bayer Pharmaceuticals Corporation Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
AU2003224549A1 (en) 2002-04-17 2003-10-27 Biovitrum Ab Nad)p)h oxidase inhibitors for increased glucose uptake and treatment of type ii diabetes
AU2003252140A1 (en) * 2002-07-24 2004-02-09 Janssen Pharmaceutica N.V. Acetylenic compounds useful in treating inflammatory disorders
US7022703B2 (en) 2003-07-24 2006-04-04 Janssen Pharmaceutica, N.V. Acetylenic compound useful in treating inflammatory disorders
US7119214B2 (en) * 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
CN102267990B (zh) * 2011-06-03 2013-11-13 浙江工业大学 一种2,3-二氢苯并呋喃类衍生物及其制备与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体

Also Published As

Publication number Publication date
IL104356A0 (en) 1993-05-13
GB9200623D0 (en) 1992-03-11
KR930016413A (ko) 1993-08-26
TW212796B (es) 1993-09-11
CA2086987A1 (en) 1993-07-14
PL297337A1 (en) 1994-01-24
EP0551662A1 (en) 1993-07-21
HUT64952A (en) 1994-03-28
ZA93190B (en) 1993-08-13
JPH05271214A (ja) 1993-10-19
HU9300078D0 (en) 1993-04-28
AU3108293A (en) 1993-07-15
CN1074904A (zh) 1993-08-04

Similar Documents

Publication Publication Date Title
MX9207557A (es) Derivados de acidos benzofuranil- y tiofenilmetiltio-alcanocarboxilicos, procedimiento para su preparacion y medicamentos que los contienen.
AR005703A1 (es) Oxazolidinonas sustituidas, procedimiento para su preparacion, uso de las mismas para preparar medicamentos y medicamentos que las contienen
PA8468401A1 (es) Compuestos para el tratamiento de la isquemia
ES2089687T3 (es) 4-fenil-piridonas y 4-fenil-2-alcoxipiridinas sustituidas como inhibidores de la hmg-coa-reductasa.
ES2059789T3 (es) Esteroides sustituidos con acido fosfinico como inhibidores de la esteroide-5 alfa-reductasa.
ES2191320T3 (es) Derivados de piperazina y su uso como agentes anti-inflamatorios.
MX9206503A (es) Nuevos derivados de lupano, proceso para su preparacion y composicion farmaceutica que los contiene.
ECSP941104A (es) Derivados de 2,6 diaminopurina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
ES2152222T3 (es) Sulfonamidas, su preparacion y su uso como medicamento e intermedio.
ES2059575T3 (es) Aductos modificados de poliepoxido y polioxialquilen-poliamidas.
ES2032376T3 (es) Procedimiento para preparar 2-sustituidos-(amino-sustituidos)-n-arilalquil-3-(indol-3-il)propanimidas.
ES2052603T3 (es) Derivados de bencimidazol, procedimiento para su produccion y composicion farmaceutica que los contienen.
ES2172937T3 (es) 21-hidroxi-6,19-oxidoprogesterona(21oh-6op) como medicamento para tratar el exceso de glucocorticoides.
DE3887151D1 (de) Inhibitoren für zellenzuwachs und methoden für krebsbehandlung.
ES2076595T3 (es) Derivados de amidinofenilalanina, procedimiento para su preparacion, su empleo y agentes que los contienen.
DK0869965T3 (da) Steroidnitritesterderivater anvendelige som antiinflammatoriske lægemidler
ES2058191T3 (es) Acidos 2-fenil-4-quinolincarboxilicos substituidos.
ES2059534T3 (es) Nuevos derivados benzopiranos antihipertensivos.
MX9302487A (es) Piridonas sustituidas por bifenilmetilo, procedimiento para su obtencion y medicamentos que las contienen.
ES2177811T3 (es) Uso de nitroflavonoides para el tratamiento de la ansiedad.
MX9204613A (es) Nitratos organicos, procedimientos para su preparacion y su uso en el tratamiento de enfermedades cardiovasculares
MX9302951A (es) Composicion farmaceutica para tratar la hiperproliferacion celular.
ES2196069T3 (es) Derivados morfinoides condensados con heterociclos.
ES2052850T3 (es) Un procedimiento para preparar un compuesto de hidrazona.
ES2171743T3 (es) Derivados de amidinas e isotioureas como inhibidores de la enzima sintasa de oxido nitrico.